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MOLECULAR BIOLOGY OF THE CELL, SIXTH EDITION BRUCE ALBERTS TEST BANK
CHAPTER 3: PROTEINS
ANSWERS ARE BELOW
1. At Physiological Ph, What Is The Approximate Net Charge Of A Hexapeptide
With The Following Amino Acid Sequence?
A. –2
B. –1
C. 0
D. +1
E. +2
2. Which Of The Following Pairs Of Amino Acid Residues Would You Expect To
Form Ionic Bonds?
A. Glutamic Acid And Glutamine
B. Arginine And Lysine
C. Lysine And Glutamic Acid
D. Tryptophan And Tyrosine
E. Tyrosine And Glutamine
3. Which Of The Following Stretches Of Amino Acid Residues Would You Expect To
Find In The Interior Of Protein Molecules?
A. Ala-Asp-Asp-Tyr-Arg
B. Gly-Lys-Ser-Pro-Thr
C. Phe-Glu-Gln-Glu-Asn
D. Ala-Val-Leu-Ile-Trp
E. Gly-Tyr-His-Arg-His
4. Which Of The Following Is NOT The Role Of Molecular Chaperones In The Folding Of
Cellular Proteins?
A. They Assist Proteins In Folding Into Their Correct Conformations.
B. They Help Prevent Formation Of Protein Aggregates.
C. They Specify The Final Three-Dimensional Shape Of Proteins.
D. They Catalyze The Folding Of Proteins In The Crowded Environment Of The Cell.
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E. They Make The Protein-Folding Process In The Cell More Reliable.
5. The Observation That Proteins Often Renature Into Their Original Conformations
After They Have Been Unfolded By Denaturing Solvents Implies That …
A. The Information Needed To Specify The Three-Dimensional Shape Of A Protein
Is Encoded In Its Amino Acid Sequence.
B. The Cell Does Not Need Molecular Chaperones For Survival.
C. The Final Folded Structure Of A Protein Is Usually NOT The One With The
Lowest Free Energy.
D. Each Protein Folds Into Several Different Conformations Inside The Cell.
E. All Of The Above.
6. Imagine A Cellular Protein Composed Of 3000 Amino Acid Residues In One
Continuous Polypeptide Chain. This Protein Is Almost Certainly …
A. Extracellular.
B. Globular.
C. Multidomain.
D. Composed Of Mostly Α-Helical Regions.
E. Intrinsically Disordered.
7. For Each Of The Following Cartoon Representations From Left To Right, Indicate
Whether The Protein Structure Is Composed Of Only Α Helices (1), Only Parallel Β Sheets
(2), Only Antiparallel Β Sheets (3), Α Helices Plus Parallel Β Sheets (4), Or Α Helices Plus
Antiparallel Β Sheets (5) As Repetitive Secondary Structure Elements. Your Answer Would
Be A Four-Digit Number Composed Of Digits 1 To 5 Only, E.G. 5513.
Images Created In Pymol, From PDB Entries 1STU, 2LPC, 1SA8, And 3BOB.
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8. Protein Secondary Structure Elements Such As Α Helices And Β Sheets Constitute
The Major Regular Folding Patterns In Proteins. With Regard To These Elements, …
A. Hydrogen-Bonding Between The Amino Acid Side Chains Defines The Type Of
Secondary Structure.
B. A Certain Short Amino Acid Sequence Always Adopts The Same Secondary
Structure.
C. Only A Few Specific Amino Acid Sequences Can Adopt These Repetitive Structures.
D. The Folding Patterns Result From Hydrogen-Bonding Between The N–H And
C=O Groups In The Polypeptide Backbone.
E. All Of The Above.
9. Which Of The Following Is NOT True Regarding The Members Of A Protein
Family In General?
A. They Have Similar Three-Dimensional Conformations.
B. They Share An Ancestry; I.E. They Are Homologs.
C. They Can Functionally Replace Each Other.
D. Their Gene Sequence Is Less Well Conserved Than Their Structure.
E. Over Evolutionary Time Scales, The Family Has Expanded Mainly Through
Gene Duplication Events.
10. The Number Of Ways In Which Protein Domains Fold In Nature Is Limited.
Which Of The Following Is A Better Estimate Of This Number?
A. 200
B. 2000
C. 200,000
D. 2,000,000
E. 20 Million
11. The Human Estrogen Receptor Is A Symmetrical Dimeric Nuclear Protein That Can
Regulate Gene Expression By Binding To A DNA Sequence Called An Estrogen Response
Element (ERE) Near The Promoter Of Its Target Genes. Each Subunit Of The Receptor Binds
To About Six Base Pairs Of DNA. Which Of The Following Sequences Is A Likely Candidate
For The ERE? The Sequences Are Written In The 5′-To-3′ Direction. The Letter N
Represents Any Of The Four DNA Bases.
A. AGGTCANNNTGACCT
B. AGGTCANNNAGGTCA
C. AGGTCANNNACTGGA
D. AGGTCANNNATATAT
MOLECULAR BIOLOGY OF THE CELL, SIXTH EDITION BRUCE ALBERTS TEST BANK
CHAPTER 3: PROTEINS
ANSWERS ARE BELOW
1. At Physiological Ph, What Is The Approximate Net Charge Of A Hexapeptide
With The Following Amino Acid Sequence?
A. –2
B. –1
C. 0
D. +1
E. +2
2. Which Of The Following Pairs Of Amino Acid Residues Would You Expect To
Form Ionic Bonds?
A. Glutamic Acid And Glutamine
B. Arginine And Lysine
C. Lysine And Glutamic Acid
D. Tryptophan And Tyrosine
E. Tyrosine And Glutamine
3. Which Of The Following Stretches Of Amino Acid Residues Would You Expect To
Find In The Interior Of Protein Molecules?
A. Ala-Asp-Asp-Tyr-Arg
B. Gly-Lys-Ser-Pro-Thr
C. Phe-Glu-Gln-Glu-Asn
D. Ala-Val-Leu-Ile-Trp
E. Gly-Tyr-His-Arg-His
4. Which Of The Following Is NOT The Role Of Molecular Chaperones In The Folding Of
Cellular Proteins?
A. They Assist Proteins In Folding Into Their Correct Conformations.
B. They Help Prevent Formation Of Protein Aggregates.
C. They Specify The Final Three-Dimensional Shape Of Proteins.
D. They Catalyze The Folding Of Proteins In The Crowded Environment Of The Cell.
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E. They Make The Protein-Folding Process In The Cell More Reliable.
5. The Observation That Proteins Often Renature Into Their Original Conformations
After They Have Been Unfolded By Denaturing Solvents Implies That …
A. The Information Needed To Specify The Three-Dimensional Shape Of A Protein
Is Encoded In Its Amino Acid Sequence.
B. The Cell Does Not Need Molecular Chaperones For Survival.
C. The Final Folded Structure Of A Protein Is Usually NOT The One With The
Lowest Free Energy.
D. Each Protein Folds Into Several Different Conformations Inside The Cell.
E. All Of The Above.
6. Imagine A Cellular Protein Composed Of 3000 Amino Acid Residues In One
Continuous Polypeptide Chain. This Protein Is Almost Certainly …
A. Extracellular.
B. Globular.
C. Multidomain.
D. Composed Of Mostly Α-Helical Regions.
E. Intrinsically Disordered.
7. For Each Of The Following Cartoon Representations From Left To Right, Indicate
Whether The Protein Structure Is Composed Of Only Α Helices (1), Only Parallel Β Sheets
(2), Only Antiparallel Β Sheets (3), Α Helices Plus Parallel Β Sheets (4), Or Α Helices Plus
Antiparallel Β Sheets (5) As Repetitive Secondary Structure Elements. Your Answer Would
Be A Four-Digit Number Composed Of Digits 1 To 5 Only, E.G. 5513.
Images Created In Pymol, From PDB Entries 1STU, 2LPC, 1SA8, And 3BOB.
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
8. Protein Secondary Structure Elements Such As Α Helices And Β Sheets Constitute
The Major Regular Folding Patterns In Proteins. With Regard To These Elements, …
A. Hydrogen-Bonding Between The Amino Acid Side Chains Defines The Type Of
Secondary Structure.
B. A Certain Short Amino Acid Sequence Always Adopts The Same Secondary
Structure.
C. Only A Few Specific Amino Acid Sequences Can Adopt These Repetitive Structures.
D. The Folding Patterns Result From Hydrogen-Bonding Between The N–H And
C=O Groups In The Polypeptide Backbone.
E. All Of The Above.
9. Which Of The Following Is NOT True Regarding The Members Of A Protein
Family In General?
A. They Have Similar Three-Dimensional Conformations.
B. They Share An Ancestry; I.E. They Are Homologs.
C. They Can Functionally Replace Each Other.
D. Their Gene Sequence Is Less Well Conserved Than Their Structure.
E. Over Evolutionary Time Scales, The Family Has Expanded Mainly Through
Gene Duplication Events.
10. The Number Of Ways In Which Protein Domains Fold In Nature Is Limited.
Which Of The Following Is A Better Estimate Of This Number?
A. 200
B. 2000
C. 200,000
D. 2,000,000
E. 20 Million
11. The Human Estrogen Receptor Is A Symmetrical Dimeric Nuclear Protein That Can
Regulate Gene Expression By Binding To A DNA Sequence Called An Estrogen Response
Element (ERE) Near The Promoter Of Its Target Genes. Each Subunit Of The Receptor Binds
To About Six Base Pairs Of DNA. Which Of The Following Sequences Is A Likely Candidate
For The ERE? The Sequences Are Written In The 5′-To-3′ Direction. The Letter N
Represents Any Of The Four DNA Bases.
A. AGGTCANNNTGACCT
B. AGGTCANNNAGGTCA
C. AGGTCANNNACTGGA
D. AGGTCANNNATATAT
