UTA NURS 5334 Quiz 2: Cephalosporins, Carbapenems, Monobactams & Glycopeptides Advanced Pharmacology NP Board Exam Preparation |10 Practice Questions & Rationales

Quiz 2: Cephalosporins, Carbapenems, Monobactams & Glycopeptides
Advanced Pharmacology NP Board Exam Preparation • 10 Practice Questions & Rationales




1. A 20-year-old female presents with acute severe bacterial meningitis. Which cephalosporin achieves adequate CSF
penetration and is a first-line agent?

A. Cefazolin
B. Cephalexin
C. Cefotaxime
D. Cefuroxime axetil

Correct Answer: C — Cefotaxime and Ceftriaxone (3rd generation) penetrate well into the CSF and are first-line for bacterial
meningitis.




2. Which advanced generation cephalosporin is the ONLY beta-lactam antibiotic available in the US that covers MRSA?

A. Cefepime
B. Ceftaroline
C. Ceftazidime
D. Cefoxitin

Correct Answer: B — Ceftaroline is an advanced generation cephalosporin engineered to bind PBP2a, giving it activity against
MRSA.




3. A patient with a documented history of severe anaphylaxis to Penicillin VK requires IV treatment for Pseudomonas
aeruginosa pyelonephritis. Which beta-lactam is safe?

A. Ampicillin/Sulbactam
B. Cefepime
C. Aztreonam
D. Meropenem

Correct Answer: C — Aztreonam (a monobactam) shows virtually no cross-reactivity with penicillin antibodies (except potential side-
chain cross-reactivity with ceftazidime) and covers Gram-negative aerobes like Pseudomonas.




4. Which 3rd generation cephalosporin is eliminated primarily via the biliary system into feces, requiring NO renal
dosage adjustment?

A. Ceftazidime
B. Cefotaxime
C. Ceftriaxone
D. Cefepime

Correct Answer: C — Ceftriaxone is excreted via bile into feces; thus, dose reduction is unnecessary in renal impairment.




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