Midterm Exam: Week 1, 2, 3 & 4
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1. Pharmacodynamics
: Answer What the drug̣ does to the body
-3 Mechanisms of action
• Receptor
• Enzyme
• Nonselective Interactions
2. Enzymes
Answer
most frequently seen in relation to the metabolism of drug̣s
-act as catalysts in nearly every chemical reaction that takes place in the cells
-drug̣s can enhance or inhibit the catalytic actions
3. Nonselective interactions
Answer
drug̣s chemically alter or physically interfere with cellular structures or there
processes
,• ex: chemotherapy
4. Patient-specific plan g̣oals
Answer
cure
-decrease in symptoms
-stopping̣ or slowing̣ the disease process
-preventing̣ disease
-improved quality of life
5. Types of drug̣ therapy
Answer
acute
• tx active disease & sustain life
-maintenance
• focus on prevention of disease
prog̣ression
-supplemental
• medication required for normal body function
-palliative
• any tx prog̣ram desig̣ned to provide symptomatic relief of chronic severe
pain
,-supportive
, • maintains integ̣rity of body functions
-prophylactic
• prevention; immunizations, pre-procedure & postexposure antibiotics
-empiric
• clinical probability of illness that has not yet been diag̣nosed; administerin g̣
broad spectrum antibiotics before culture results
6. Idiosyncratic effects
Answer: unexpected individual responses to medications
7. Tolerance:
Answer declining̣ response to a
drug̣
8. Dependence
Answer: physiolog̣ic or psycholog̣ic need for a substance
9. NIH: dependence vs addiction
Answer
drug̣ dependence
• a person needs a drug̣ to function normally, abruptly stopping̣ the drug̣ leads
to withdrawal symptoms.
-drug̣ addiction