The University of Texas at Arlington NURS 5334
NURS 5334 Antimicrobials
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gram (-), gram (+), protozoal
Acne, STI (chlamydia & Syphilis), Lyme, Rocky Mountain fever, malaria
prevention, respiratory infections
teratogenic, sit upright, take on empty stomach, photosensitivity, avoid in
kids <8
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1 Peak 2 Antiproliferatives
3 Tetracyclines (-cyclines) 4 Basiliximab (Simulect)
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Peak highest concentration indicates if dosage is too
high and potentially toxic
Trough lowest concentration measured just before next
dose. Confirms that concentration remains above
minimum effective level throughout dosing period.
First Pass Metabolism Concentration of drug is significantly reduced by
liver and GI before it reaches bloodstream.
If more stable to 1st pass- lower doses are needed
bc more drug reaches systemic circulation with
higher bioavailability.
Antithymocyte Globulin used at time of transplant to prevent early rejection
or in severe rejection or steroid resistant.
Thyroglobulin-rabbit
Atgam- horse
Basiliximab (Simulect) Prevents acute kidney rejection. Inhibits ability to
activate t-cell response. Used in induction as
apposed to rejection.
, Alemtuzumab (Monoclonal) Causes B/T cell depletion. Used in
transplant induction and antirejection. Treats MS/
CLL
Rituximab B-cell depletion. B-cell lymphoma, post-transplant
lymphoproliferative disease, RA. BB warning:
reactivation of JC virus and Hep B.
Bortezomib proteasome inhibitor that causes cell cycle arrest
and apoptosis of normal plasma cells thus
decreasing bodies ability to make antibodies.
Metabolized. by CYP450.
IVIG inhibits binding of antibodies to transplanted organ
and activation of complement.
Used for pretransplant desensitization and treating
AMR (antibody-mediated rejection)
Calcineurin inhibitors Cyclosporine (CYA)
Tacrolimus- renal, liver, cardiac organ transplant.
trough levels.
renal toxicity.
Costimulation Blockers prevents immune system (t-cells) from attacking a
transplanted organ. Also, approved for treating
autoimmune disorders (RA)
Belatacept- organ rejection
Abatacept- RA
Draw titers for EBV prior to administration
mTOR Inhibitors suppress immune system and treat cancer.
Rapamycin- cardiac stents
Everolimus- breast cancer
NURS 5334 Antimicrobials
Leave the first rating
Practice questions for this set
Learn 1 /7 Study with Learn
gram (-), gram (+), protozoal
Acne, STI (chlamydia & Syphilis), Lyme, Rocky Mountain fever, malaria
prevention, respiratory infections
teratogenic, sit upright, take on empty stomach, photosensitivity, avoid in
kids <8
Choose an answer
1 Peak 2 Antiproliferatives
3 Tetracyclines (-cyclines) 4 Basiliximab (Simulect)
Don't know?
,Terms in this set (161) Hide definitions
Peak highest concentration indicates if dosage is too
high and potentially toxic
Trough lowest concentration measured just before next
dose. Confirms that concentration remains above
minimum effective level throughout dosing period.
First Pass Metabolism Concentration of drug is significantly reduced by
liver and GI before it reaches bloodstream.
If more stable to 1st pass- lower doses are needed
bc more drug reaches systemic circulation with
higher bioavailability.
Antithymocyte Globulin used at time of transplant to prevent early rejection
or in severe rejection or steroid resistant.
Thyroglobulin-rabbit
Atgam- horse
Basiliximab (Simulect) Prevents acute kidney rejection. Inhibits ability to
activate t-cell response. Used in induction as
apposed to rejection.
, Alemtuzumab (Monoclonal) Causes B/T cell depletion. Used in
transplant induction and antirejection. Treats MS/
CLL
Rituximab B-cell depletion. B-cell lymphoma, post-transplant
lymphoproliferative disease, RA. BB warning:
reactivation of JC virus and Hep B.
Bortezomib proteasome inhibitor that causes cell cycle arrest
and apoptosis of normal plasma cells thus
decreasing bodies ability to make antibodies.
Metabolized. by CYP450.
IVIG inhibits binding of antibodies to transplanted organ
and activation of complement.
Used for pretransplant desensitization and treating
AMR (antibody-mediated rejection)
Calcineurin inhibitors Cyclosporine (CYA)
Tacrolimus- renal, liver, cardiac organ transplant.
trough levels.
renal toxicity.
Costimulation Blockers prevents immune system (t-cells) from attacking a
transplanted organ. Also, approved for treating
autoimmune disorders (RA)
Belatacept- organ rejection
Abatacept- RA
Draw titers for EBV prior to administration
mTOR Inhibitors suppress immune system and treat cancer.
Rapamycin- cardiac stents
Everolimus- breast cancer
