Pituitary Hormones
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•Posterior Lobe Pituitary
▫Antidiuretic hormone (ADH): Kidneys, osmolality
•Anterior Lobe Pituitary
▫Somatotropes: secrete growth hormone (GH): Liver, bones, muscle,
metabolism
▫Thyrotropes: secrete thyroid stimulating hormone (TSH): Thyroid gland, T3
T4
▫Corticotropes: secrete adrenocorticotropic hormone (ACTH): Adrenal
Cortex, Cortisol
Hypothyroidism Etiology
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, •Most cases are primary (thyroid gland dysfunction)
•Congenital
•Irradiation of the Thyroid
•Surgical removal of Thyroid
•Lithium inhibits TH synthesis
stress
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-Blood sugar increases
-More glucose made available for fight or flight
-Can be caused by trauma of infection
•Injury, illness, pain, and _________ hormones:
•All increase production of glucose
•Catecholamines and corticosteroids increase
Glucagon levels
Liver production of glucose
But decreases the use of glucose in muscle/fat tissue
"Stress hyperglycemia"
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Clinical
Manifestations
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•Increased water reabsorption
•Low osmolality (too thin)
•Weakness
•Muscle cramps
•Orthostatic hypotension
•Low lab values due to dilution
•Hyponatremia
▫Confusion
, ▫Lethargy
▫Coma
•Don't pee
•Fluid volume overload
Respiratory Response
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Look at pH to know if body system is compensating
effectively
Myxedema
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, •Occurs in severe prolonged thyroid deficiency
•Generalized, non-pitting edema
•Fluid retention due to accumulation of glycosaminoglycans
in interstitial spaces
-Slows down function of organs
-Deposits everywhere in the body and can cause organ
failure
•Present to emergency room with:
▫AMS, thermoregulation problems
▫Hx of sepsis, trauma, certain medication use
•"coma" happens if left untreated
-Body process slowed down so much that the heart stops
▫Medical emergency
▫60% mortality rate
Anterior Lobe Pituitary Hormones
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▫Somatotropes: secrete growth hormone (GH): Liver, bones, muscle,
metabolism
▫Thyrotropes: secrete thyroid stimulating hormone (TSH): Thyroid gland, T3
T4
▫Corticotropes: secrete adrenocorticotropic hormone (ACTH): Adrenal
Cortex, Cortisol
Type II Diabetes Mellitus Patho
Give this one a try later!
Give this one a try later!
•Posterior Lobe Pituitary
▫Antidiuretic hormone (ADH): Kidneys, osmolality
•Anterior Lobe Pituitary
▫Somatotropes: secrete growth hormone (GH): Liver, bones, muscle,
metabolism
▫Thyrotropes: secrete thyroid stimulating hormone (TSH): Thyroid gland, T3
T4
▫Corticotropes: secrete adrenocorticotropic hormone (ACTH): Adrenal
Cortex, Cortisol
Hypothyroidism Etiology
Give this one a try later!
, •Most cases are primary (thyroid gland dysfunction)
•Congenital
•Irradiation of the Thyroid
•Surgical removal of Thyroid
•Lithium inhibits TH synthesis
stress
Give this one a try later!
-Blood sugar increases
-More glucose made available for fight or flight
-Can be caused by trauma of infection
•Injury, illness, pain, and _________ hormones:
•All increase production of glucose
•Catecholamines and corticosteroids increase
Glucagon levels
Liver production of glucose
But decreases the use of glucose in muscle/fat tissue
"Stress hyperglycemia"
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Clinical
Manifestations
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•Increased water reabsorption
•Low osmolality (too thin)
•Weakness
•Muscle cramps
•Orthostatic hypotension
•Low lab values due to dilution
•Hyponatremia
▫Confusion
, ▫Lethargy
▫Coma
•Don't pee
•Fluid volume overload
Respiratory Response
Give this one a try later!
Look at pH to know if body system is compensating
effectively
Myxedema
Give this one a try later!
, •Occurs in severe prolonged thyroid deficiency
•Generalized, non-pitting edema
•Fluid retention due to accumulation of glycosaminoglycans
in interstitial spaces
-Slows down function of organs
-Deposits everywhere in the body and can cause organ
failure
•Present to emergency room with:
▫AMS, thermoregulation problems
▫Hx of sepsis, trauma, certain medication use
•"coma" happens if left untreated
-Body process slowed down so much that the heart stops
▫Medical emergency
▫60% mortality rate
Anterior Lobe Pituitary Hormones
Give this one a try later!
▫Somatotropes: secrete growth hormone (GH): Liver, bones, muscle,
metabolism
▫Thyrotropes: secrete thyroid stimulating hormone (TSH): Thyroid gland, T3
T4
▫Corticotropes: secrete adrenocorticotropic hormone (ACTH): Adrenal
Cortex, Cortisol
Type II Diabetes Mellitus Patho
Give this one a try later!