Diabetes Insipidus
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insufficient ADH
caused by brain trauma
Polyuria
Polydipsia
may void 15L/ day
decreased specific gravity
drink up to 15 L/day to correct
thirst and dry mouth
Treatment: Give ADH, monitor labs
BUN, creatinine and electrolytes
Duchenne Muscular Dystrophy
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, Affects only males- X linked disorder
Due to genetic mutation
Deficiency in dystrophin
Calf muscles are notably enlarged
Treatment: In some cases, corticosteriod therapy may prolong muscle
strength and independent ambulation
Cholinergic Crisis
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Excessive medication
Fasciculations (especially around mouth)
Difficulty chewing, swallowing, speaking
Advancing muscle weakness
Increased secretions
Respiratory distress
Gluconeogenesis
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production of glucose from amino acids in liver
Fasting state
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, dominated by glucagon
Glucose is produced
by glycogenolysis
By gluconeogenesis
Glucagon-responsible for 75% of glucose production
Lipolysis is primary source of energy to muscles
Gout
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Disturbance of uric acid metabolism leads to deposition of urate salts in
articular tissue
Hyperuricemia-hallmark
Accumulation of Tophi
Osteosarcoma
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Pain-progressive to intense
Pathologic fracture
Compromised joint function
Metastasis to lung
Conservative surgery
Chemotherapy
5 year survival rate using combination of above 70-85%
Amputation
Acute hyperglycemia
Give this one a try later!
insufficient ADH
caused by brain trauma
Polyuria
Polydipsia
may void 15L/ day
decreased specific gravity
drink up to 15 L/day to correct
thirst and dry mouth
Treatment: Give ADH, monitor labs
BUN, creatinine and electrolytes
Duchenne Muscular Dystrophy
Give this one a try later!
, Affects only males- X linked disorder
Due to genetic mutation
Deficiency in dystrophin
Calf muscles are notably enlarged
Treatment: In some cases, corticosteriod therapy may prolong muscle
strength and independent ambulation
Cholinergic Crisis
Give this one a try later!
Excessive medication
Fasciculations (especially around mouth)
Difficulty chewing, swallowing, speaking
Advancing muscle weakness
Increased secretions
Respiratory distress
Gluconeogenesis
Give this one a try later!
production of glucose from amino acids in liver
Fasting state
Give this one a try later!
, dominated by glucagon
Glucose is produced
by glycogenolysis
By gluconeogenesis
Glucagon-responsible for 75% of glucose production
Lipolysis is primary source of energy to muscles
Gout
Give this one a try later!
Disturbance of uric acid metabolism leads to deposition of urate salts in
articular tissue
Hyperuricemia-hallmark
Accumulation of Tophi
Osteosarcoma
Give this one a try later!
Pain-progressive to intense
Pathologic fracture
Compromised joint function
Metastasis to lung
Conservative surgery
Chemotherapy
5 year survival rate using combination of above 70-85%
Amputation
Acute hyperglycemia
