NCLEX Medical-Surgical Pharmacology Examination Questions And
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
1. A client receiving cisplatin therapy reports a high-pitched
ringing in both ears. Which cranial nerve is most likely
affected by this medication toxicity?
• A. Cranial Nerve II
• B. Cranial Nerve VIII
• C. Cranial Nerve X
• D. Cranial Nerve XII
• Answer: B. Cranial Nerve VIII (Ototoxicity affects the
vestibulocochlear nerve).
2. Cytotoxic chemotherapy drugs target cells with a high
growth fraction. Which five bodily areas are primarily
composed of high growth fraction cells?
• A. Hair, gastrointestinal tract, skin, reproductive organs,
and bone marrow
• B. Brain, skeletal muscle, heart, liver, and pancreas
• C. Lungs, kidneys, spleen, thyroid, and adrenal glands
• D. Cornea, cartilage, tendons, ligaments, and bone matrix
• Answer: A. Hair, gastrointestinal tract, skin, reproductive
organs, and bone marrow.
,NCLEX Medical-Surgical Pharmacology Examination Questions And
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
3. Which laboratory values must be monitored closely for a
client receiving intravenous vancomycin to prevent
irreversible organ damage?
• A. Serum calcium and magnesium
• B. Peak and trough levels along with BUN and serum
creatinine
• C. Prothrombin time and INR
• D. Thyroid-stimulating hormone and free T4
• Answer: B. Peak and trough levels along with BUN and
serum creatinine (to prevent nephrotoxicity and
ototoxicity).
4. A client taking digoxin reports seeing yellow-green halos
around lights and experiencing persistent nausea. Which
nursing action is priority?
• A. Administer the next scheduled dose with food
• B. Hold the medication and notify the healthcare provider
• C. Encourage increased fluid intake to flush the kidneys
• D. Document the finding as a normal expected side effect
• Answer: B. Hold the medication and notify the healthcare
provider (classic signs of digitalis toxicity).
, NCLEX Medical-Surgical Pharmacology Examination Questions And
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
5. Before administering digoxin, the nurse assesses the
client's apical pulse for one full minute. At what heart rate
threshold should the nurse withhold the dose?
• A. Below 50 beats per minute
• B. Below 60 beats per minute
• C. Below 70 beats per minute
• D. Below 80 beats per minute
• Answer: B. Below 60 beats per minute.
6. A client with heart failure is prescribed digoxin and
furosemide. Why is a serum potassium level of 3.1 mEq/L
dangerous for this client?
• A. Hypokalemia causes immediate respiratory paralysis
• B. Low potassium increases the risk of severe digitalis
toxicity
• C. Furosemide neutralizes the therapeutic effect of digoxin
completely
• D. Potassium depletion stops all renal filtration
• Answer: B. Low potassium potentiates digoxin binding to
myocardial cells, heightening toxicity risk.
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
1. A client receiving cisplatin therapy reports a high-pitched
ringing in both ears. Which cranial nerve is most likely
affected by this medication toxicity?
• A. Cranial Nerve II
• B. Cranial Nerve VIII
• C. Cranial Nerve X
• D. Cranial Nerve XII
• Answer: B. Cranial Nerve VIII (Ototoxicity affects the
vestibulocochlear nerve).
2. Cytotoxic chemotherapy drugs target cells with a high
growth fraction. Which five bodily areas are primarily
composed of high growth fraction cells?
• A. Hair, gastrointestinal tract, skin, reproductive organs,
and bone marrow
• B. Brain, skeletal muscle, heart, liver, and pancreas
• C. Lungs, kidneys, spleen, thyroid, and adrenal glands
• D. Cornea, cartilage, tendons, ligaments, and bone matrix
• Answer: A. Hair, gastrointestinal tract, skin, reproductive
organs, and bone marrow.
,NCLEX Medical-Surgical Pharmacology Examination Questions And
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
3. Which laboratory values must be monitored closely for a
client receiving intravenous vancomycin to prevent
irreversible organ damage?
• A. Serum calcium and magnesium
• B. Peak and trough levels along with BUN and serum
creatinine
• C. Prothrombin time and INR
• D. Thyroid-stimulating hormone and free T4
• Answer: B. Peak and trough levels along with BUN and
serum creatinine (to prevent nephrotoxicity and
ototoxicity).
4. A client taking digoxin reports seeing yellow-green halos
around lights and experiencing persistent nausea. Which
nursing action is priority?
• A. Administer the next scheduled dose with food
• B. Hold the medication and notify the healthcare provider
• C. Encourage increased fluid intake to flush the kidneys
• D. Document the finding as a normal expected side effect
• Answer: B. Hold the medication and notify the healthcare
provider (classic signs of digitalis toxicity).
, NCLEX Medical-Surgical Pharmacology Examination Questions And
Correct Answers (Verified Answers) Plus Rationales 2026/2027 Q&A |
Instant Download Pdf
5. Before administering digoxin, the nurse assesses the
client's apical pulse for one full minute. At what heart rate
threshold should the nurse withhold the dose?
• A. Below 50 beats per minute
• B. Below 60 beats per minute
• C. Below 70 beats per minute
• D. Below 80 beats per minute
• Answer: B. Below 60 beats per minute.
6. A client with heart failure is prescribed digoxin and
furosemide. Why is a serum potassium level of 3.1 mEq/L
dangerous for this client?
• A. Hypokalemia causes immediate respiratory paralysis
• B. Low potassium increases the risk of severe digitalis
toxicity
• C. Furosemide neutralizes the therapeutic effect of digoxin
completely
• D. Potassium depletion stops all renal filtration
• Answer: B. Low potassium potentiates digoxin binding to
myocardial cells, heightening toxicity risk.
