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Section A: USPSTF Preventive Health Guidelines (20 Questions)
Q1: A 55-year-old asymptomatic woman asks about routine abdominal aortic aneurysm
(AAA) screening. She has never smoked. What does the USPSTF recommend?
A. Grade A recommendation for one-time ultrasound screening
B. Grade B recommendation for screening every 5 years
C. Grade D recommendation against routine screening [CORRECT]
D. Grade I recommendation with insufficient evidence
Correct Answer: C
Rationale: The USPSTF recommends against routine AAA screening in women who
have never smoked (Grade D: potential harms outweigh benefits). Screening is
recommended only for men aged 65-75 who have ever smoked.
Q2: Which USPSTF grade indicates that the service is recommended and there is high
certainty of substantial net benefit?
A. Grade C
B. Grade B
C. Grade A [CORRECT]
D. Grade I
Correct Answer: C
Rationale: Grade A means the USPSTF recommends the service with high certainty of
substantial net benefit. Grade B also recommends but with moderate certainty; Grade C
is selective offering; Grade D recommends against; Grade I is insufficient evidence.
,Q3: A 22-year-old female patient asks when she should begin cervical cancer screening.
She became sexually active at age 16. According to USPSTF guidelines, when should
Pap smear screening begin?
A. At age 18, because she is sexually active
B. At age 25, to allow HPV clearance
C. At age 21, regardless of sexual history [CORRECT]
D. Only after she has had three or more sexual partners
Correct Answer: C
Rationale: USPSTF recommends cervical cancer screening begin at age 21 regardless
of sexual activity onset or number of partners. Starting earlier does not reduce mortality
and increases harms from unnecessary procedures.
Q4: According to USPSTF guidelines, what is the recommended screening interval for a
25-year-old woman with normal prior Pap results?
A. Pap smear annually
B. Pap smear every 2 years
C. Pap smear every 3 years [CORRECT]
D. Pap + HPV co-testing every 5 years
Correct Answer: C
Rationale: For women ages 21-29, USPSTF recommends Pap smear screening every 3
years. HPV co-testing is not recommended in this age group due to high transient HPV
infection rates.
Q5: A 45-year-old woman with normal prior screening asks about cervical cancer
screening. What does USPSTF recommend as the preferred approach?
A. Pap smear every 3 years
B. Pap + HPV co-testing every 5 years [CORRECT]
C. Annual Pap smear
D. HPV testing alone every 3 years
Correct Answer: B
,Rationale: For women ages 30-65, the preferred screening strategy is Pap + HPV
co-testing every 5 years. Pap alone every 3 years is an acceptable alternative. Annual
screening is not recommended.
Q6: What is the USPSTF recommendation grade for depression screening in the general
adult population?
A. Grade A
B. Grade B [CORRECT]
C. Grade C
D. Grade D
Correct Answer: B
Rationale: The USPSTF recommends screening for depression in the general adult
population, including pregnant and postpartum women, with adequate systems in place
for accurate diagnosis, effective treatment, and appropriate follow-up (Grade B).
Q7: A 50-year-old man asks about prostate cancer screening with PSA testing. What is
the USPSTF recommendation?
A. Grade A: recommend for all men
B. Grade B: recommend for high-risk men only
C. Grade C: selective offering for men aged 55-69 [CORRECT]
D. Grade D: recommend against for all men
Correct Answer: C
Rationale: PSA-based screening for prostate cancer is a Grade C recommendation:
clinicians should selectively offer screening based on professional judgment and
patient preferences. It is not a routine Grade A or B recommendation for all men.
Q8: Which of the following screening services does the USPSTF assign a Grade D
recommendation (potential harms outweigh benefits)?
A. HIV screening in adolescents and adults
B. Teaching breast self-examination [CORRECT]
C. Depression screening in adults
, D. Cervical cancer screening in women ages 21-65
Correct Answer: B
Rationale: The USPSTF recommends against teaching breast self-examination (Grade
D) because harms outweigh benefits. HIV screening is Grade A, depression screening is
Grade B, and cervical cancer screening is Grade A.
Q9: At what age should average-risk adults begin colorectal cancer screening according
to current USPSTF guidelines?
A. Age 40
B. Age 45 [CORRECT]
C. Age 50
D. Age 55
Correct Answer: B
Rationale: The USPSTF recommends screening for colorectal cancer starting at age 45
for average-risk adults. Previous guidelines started at 50, but the recommendation was
lowered to 45 based on increasing incidence in younger adults.
Q10: For average-risk adults, how frequently should colonoscopy be performed for
colorectal cancer screening?
A. Every 3 years
B. Every 5 years
C. Every 10 years [CORRECT]
D. Every 15 years
Correct Answer: C
Rationale: Colonoscopy is recommended every 10 years for average-risk adults who
choose this screening modality. Other modalities have different intervals (e.g., FIT
annually, CT colonography every 5 years).
Q11: What is the USPSTF recommendation grade for HIV screening in adolescents and
adults aged 15-65?