NSG552 / NSG 552 Exam 2 (Latest
): Psychopharmacology |
Grade A Questions and Verified
Answers | 100% Correct - Wilkes
1. A nurse practitioner explains to a patient that "what the body does to the
drug" is known as:
A. Pharmacodynamics
B. Pharmacokinetics
C. Pharmacotherapeutics
D. Pharmacogenomics
Correct Answer: B
Rationale: Pharmacokinetics describes the processes of absorption, distribution,
metabolism, and excretion (ADME)—what the body does to the drug.
Pharmacodynamics is what the drug does to the body (e.g., receptor binding and
effects).
2. The opening of which ion channel is primarily responsible for initiating an
action potential?
A. Potassium channels
B. Calcium channels
C. Sodium channels
D. Chloride channels
,Correct Answer: C
Rationale: Voltage-gated sodium channels open, allowing sodium influx and
depolarization of the neuron, which initiates the action potential. Potassium
channels then open for repolarization.
3. Which neurotransmitter is the primary inhibitory neurotransmitter in the
central nervous system?
A. Glutamate
B. Dopamine
C. GABA
D. Norepinephrine
Correct Answer: C
Rationale: GABA (gamma-aminobutyric acid) is the primary inhibitory
neurotransmitter in the CNS. It reduces neuronal excitability by increasing chloride
influx. Glutamate is the primary excitatory neurotransmitter.
4. A drug that is a CYP450 inducer will have what effect on a substrate
medication?
A. Increase the substrate's plasma level
B. Decrease the substrate's plasma level
C. No effect
D. Prolong the substrate's half-life
Correct Answer: B
Rationale: Enzyme inducers increase the rate of metabolism of substrate drugs,
,reducing their plasma levels and potentially decreasing therapeutic efficacy.
Common examples include carbamazepine, rifampin, and St. John's Wort.
Inhibitors decrease metabolism and increase levels.
5. A drug with high affinity for a receptor will:
A. Produce a greater maximum effect
B. Bind readily to the receptor at low concentrations
C. Require a high dose to produce 50% of its maximum effect
D. Be metabolized slowly by the liver
Correct Answer: B
Rationale: Affinity refers to the strength of binding between a drug and its receptor.
A drug with high affinity binds more readily, meaning it can occupy receptors at
lower concentrations and produce effects without needing high doses.
6. What is the difference between pharmacodynamics and pharmacokinetics?
A. Pharmacodynamics is what the body does to the drug; pharmacokinetics is what
the drug does to the body
B. Pharmacodynamics is what the drug does to the body; pharmacokinetics is what
the body does to the drug
C. They are the same process
D. Pharmacodynamics involves metabolism only
Correct Answer: B
Rationale: Pharmacodynamics is what the drug does to the body (receptor binding
, and effects). Pharmacokinetics is what the body does to the drug (absorption,
distribution, metabolism, excretion).
7. Which neurotransmitter profile is associated with anxiety disorders?
A. ↑ Dopamine, ↓ Serotonin, ↑ GABA
B. ↑ Norepinephrine, ↓ Serotonin, ↓ GABA
C. ↓ Norepinephrine, ↑ Serotonin, ↑ GABA
D. ↑ Serotonin, ↑ GABA, ↓ Norepinephrine
Correct Answer: B
Rationale: Anxiety disorders are associated with increased norepinephrine,
decreased serotonin, and decreased GABA neurotransmission.
8. The cytochrome P450 (CYP450) system is primarily responsible for:
A. Drug absorption in the GI tract
B. Drug metabolism in the liver
C. Drug distribution to tissues
D. Drug excretion by the kidneys
Correct Answer: B
Rationale: The CYP450 system is primarily responsible for drug metabolism in the
liver, affecting the clearance and half-life of many psychotropic medications.
): Psychopharmacology |
Grade A Questions and Verified
Answers | 100% Correct - Wilkes
1. A nurse practitioner explains to a patient that "what the body does to the
drug" is known as:
A. Pharmacodynamics
B. Pharmacokinetics
C. Pharmacotherapeutics
D. Pharmacogenomics
Correct Answer: B
Rationale: Pharmacokinetics describes the processes of absorption, distribution,
metabolism, and excretion (ADME)—what the body does to the drug.
Pharmacodynamics is what the drug does to the body (e.g., receptor binding and
effects).
2. The opening of which ion channel is primarily responsible for initiating an
action potential?
A. Potassium channels
B. Calcium channels
C. Sodium channels
D. Chloride channels
,Correct Answer: C
Rationale: Voltage-gated sodium channels open, allowing sodium influx and
depolarization of the neuron, which initiates the action potential. Potassium
channels then open for repolarization.
3. Which neurotransmitter is the primary inhibitory neurotransmitter in the
central nervous system?
A. Glutamate
B. Dopamine
C. GABA
D. Norepinephrine
Correct Answer: C
Rationale: GABA (gamma-aminobutyric acid) is the primary inhibitory
neurotransmitter in the CNS. It reduces neuronal excitability by increasing chloride
influx. Glutamate is the primary excitatory neurotransmitter.
4. A drug that is a CYP450 inducer will have what effect on a substrate
medication?
A. Increase the substrate's plasma level
B. Decrease the substrate's plasma level
C. No effect
D. Prolong the substrate's half-life
Correct Answer: B
Rationale: Enzyme inducers increase the rate of metabolism of substrate drugs,
,reducing their plasma levels and potentially decreasing therapeutic efficacy.
Common examples include carbamazepine, rifampin, and St. John's Wort.
Inhibitors decrease metabolism and increase levels.
5. A drug with high affinity for a receptor will:
A. Produce a greater maximum effect
B. Bind readily to the receptor at low concentrations
C. Require a high dose to produce 50% of its maximum effect
D. Be metabolized slowly by the liver
Correct Answer: B
Rationale: Affinity refers to the strength of binding between a drug and its receptor.
A drug with high affinity binds more readily, meaning it can occupy receptors at
lower concentrations and produce effects without needing high doses.
6. What is the difference between pharmacodynamics and pharmacokinetics?
A. Pharmacodynamics is what the body does to the drug; pharmacokinetics is what
the drug does to the body
B. Pharmacodynamics is what the drug does to the body; pharmacokinetics is what
the body does to the drug
C. They are the same process
D. Pharmacodynamics involves metabolism only
Correct Answer: B
Rationale: Pharmacodynamics is what the drug does to the body (receptor binding
, and effects). Pharmacokinetics is what the body does to the drug (absorption,
distribution, metabolism, excretion).
7. Which neurotransmitter profile is associated with anxiety disorders?
A. ↑ Dopamine, ↓ Serotonin, ↑ GABA
B. ↑ Norepinephrine, ↓ Serotonin, ↓ GABA
C. ↓ Norepinephrine, ↑ Serotonin, ↑ GABA
D. ↑ Serotonin, ↑ GABA, ↓ Norepinephrine
Correct Answer: B
Rationale: Anxiety disorders are associated with increased norepinephrine,
decreased serotonin, and decreased GABA neurotransmission.
8. The cytochrome P450 (CYP450) system is primarily responsible for:
A. Drug absorption in the GI tract
B. Drug metabolism in the liver
C. Drug distribution to tissues
D. Drug excretion by the kidneys
Correct Answer: B
Rationale: The CYP450 system is primarily responsible for drug metabolism in the
liver, affecting the clearance and half-life of many psychotropic medications.
