NSG552 / NSG 552 Exam 3 (Latest 2024 /
2025 Update): Psychopharmacology |
Complete Review with Questions and
Verified Answers | 100% Correct | Grade
A - Wilkes
SUBSTANCE USE DISORDERS — OPIOIDS (Questions 1–20)
1. What is the mechanism of action of Naloxone?
A. Mu receptor partial agonist
B. Pure opioid antagonist that competes and displaces opioids at opioid receptor
sites
C. NMDA receptor antagonist
D. GABA receptor agonist
Correct Answer: B
Rationale: Naloxone is a pure opioid antagonist that competes with and displaces
opioids at opioid receptor sites, rapidly reversing opioid intoxication and respiratory
depression.
2. What medications are used to treat opioid use disorder?
A. Naltrexone only
B. Methadone, Buprenorphine, and Buprenorphine + Naloxone
,C. Disulfiram and Acamprosate
D. Diazepam and Lorazepam
Correct Answer: B
Rationale: The primary pharmacologic treatments for opioid use disorder are
methadone, buprenorphine, and the combination product buprenorphine +
naloxone (Suboxone).
3. What medication for opioid use disorder is used with comorbid pain?
A. Methadone
B. Naltrexone
C. Buprenorphine + Naloxone
D. Buprenorphine alone
Correct Answer: C
Rationale: Buprenorphine + Naloxone (Suboxone) is the preferred treatment for
opioid use disorder when the patient also has comorbid pain, as buprenorphine
provides some analgesic effect.
4. Inappropriate use of what substance may be due to uncontrolled pain?
A. Alcohol
B. Benzodiazepines
C. Opioids
D. Stimulants
,Correct Answer: C
Rationale: Inappropriate opioid use may be driven by uncontrolled or undertreated
pain, leading patients to seek relief through non-prescribed or illicit opioids.
5. What are the Naltrexone delivery methods?
A. Tablet only
B. Injectable only
C. Tablet, Injectable, and Implant
D. Transdermal patch only
Correct Answer: C
Rationale: Naltrexone is available in three delivery methods: oral tablet (daily),
extended-release injectable (monthly), and implantable formulation (3-6 months).
6. What is one form of Naltrexone delivery method limited to inpatient use?
A. Oral tablet
B. Injectable
C. Implant
D. Transdermal patch
Correct Answer: C
Rationale: The naltrexone implant is typically limited to inpatient or closely
supervised settings due to the procedure required for insertion and removal.
, 7. What is the mechanism of action of buprenorphine?
A. Full opioid agonist
B. Mu receptor partial agonist for opioid withdrawal
C. Opioid antagonist
D. NMDA receptor antagonist
Correct Answer: B
Rationale: Buprenorphine is a partial agonist at the mu-opioid receptor, which helps
reduce opioid withdrawal symptoms and cravings while having a ceiling effect that
reduces the risk of respiratory depression.
8. What medication taken too soon after last opioid use increases the chances
of intense withdrawal that comes on very quickly (precipitated withdrawal)?
A. Methadone
B. Naltrexone
C. Buprenorphine
D. Clonidine
Correct Answer: C
Rationale: Buprenorphine, due to its high receptor affinity and partial agonist
activity, can precipitate acute withdrawal if administered too soon after the last
opioid use, typically when the patient is not yet in mild to moderate withdrawal.
9. What are the symptoms of opioid intoxication?
2025 Update): Psychopharmacology |
Complete Review with Questions and
Verified Answers | 100% Correct | Grade
A - Wilkes
SUBSTANCE USE DISORDERS — OPIOIDS (Questions 1–20)
1. What is the mechanism of action of Naloxone?
A. Mu receptor partial agonist
B. Pure opioid antagonist that competes and displaces opioids at opioid receptor
sites
C. NMDA receptor antagonist
D. GABA receptor agonist
Correct Answer: B
Rationale: Naloxone is a pure opioid antagonist that competes with and displaces
opioids at opioid receptor sites, rapidly reversing opioid intoxication and respiratory
depression.
2. What medications are used to treat opioid use disorder?
A. Naltrexone only
B. Methadone, Buprenorphine, and Buprenorphine + Naloxone
,C. Disulfiram and Acamprosate
D. Diazepam and Lorazepam
Correct Answer: B
Rationale: The primary pharmacologic treatments for opioid use disorder are
methadone, buprenorphine, and the combination product buprenorphine +
naloxone (Suboxone).
3. What medication for opioid use disorder is used with comorbid pain?
A. Methadone
B. Naltrexone
C. Buprenorphine + Naloxone
D. Buprenorphine alone
Correct Answer: C
Rationale: Buprenorphine + Naloxone (Suboxone) is the preferred treatment for
opioid use disorder when the patient also has comorbid pain, as buprenorphine
provides some analgesic effect.
4. Inappropriate use of what substance may be due to uncontrolled pain?
A. Alcohol
B. Benzodiazepines
C. Opioids
D. Stimulants
,Correct Answer: C
Rationale: Inappropriate opioid use may be driven by uncontrolled or undertreated
pain, leading patients to seek relief through non-prescribed or illicit opioids.
5. What are the Naltrexone delivery methods?
A. Tablet only
B. Injectable only
C. Tablet, Injectable, and Implant
D. Transdermal patch only
Correct Answer: C
Rationale: Naltrexone is available in three delivery methods: oral tablet (daily),
extended-release injectable (monthly), and implantable formulation (3-6 months).
6. What is one form of Naltrexone delivery method limited to inpatient use?
A. Oral tablet
B. Injectable
C. Implant
D. Transdermal patch
Correct Answer: C
Rationale: The naltrexone implant is typically limited to inpatient or closely
supervised settings due to the procedure required for insertion and removal.
, 7. What is the mechanism of action of buprenorphine?
A. Full opioid agonist
B. Mu receptor partial agonist for opioid withdrawal
C. Opioid antagonist
D. NMDA receptor antagonist
Correct Answer: B
Rationale: Buprenorphine is a partial agonist at the mu-opioid receptor, which helps
reduce opioid withdrawal symptoms and cravings while having a ceiling effect that
reduces the risk of respiratory depression.
8. What medication taken too soon after last opioid use increases the chances
of intense withdrawal that comes on very quickly (precipitated withdrawal)?
A. Methadone
B. Naltrexone
C. Buprenorphine
D. Clonidine
Correct Answer: C
Rationale: Buprenorphine, due to its high receptor affinity and partial agonist
activity, can precipitate acute withdrawal if administered too soon after the last
opioid use, typically when the patient is not yet in mild to moderate withdrawal.
9. What are the symptoms of opioid intoxication?
