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Modern Blood Banking & Transfusion by Denise Harmening Practice Exam Questions & Answers 2026–2027 | Complete Practice Test with Verified Correct Solutions | Grade A+

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Ace your Modern Blood Banking & Transfusion examination with this comprehensive 2026–2027 Practice Test, developed to help students and laboratory professionals master the essential concepts of immunohematology and transfusion medicine. This high-yield study resource includes carefully selected practice questions with verified correct solutions covering the most frequently tested topics from Denise Harmening's Modern Blood Banking & Transfusion Practices. Review essential concepts including ABO and Rh blood group systems, antibody screening and identification, compatibility testing, crossmatching, blood component therapy, donor selection, transfusion reactions, hemolytic disease of the fetus and newborn (HDFN), quality assurance, immunohematology principles, blood collection and processing, infectious disease testing, laboratory safety, and regulatory standards. Ideal for Medical Laboratory Science (MLS), Medical Laboratory Technician (MLT), Clinical Laboratory Science (CLS), and transfusion medicine students preparing for coursework, certification exams, and comprehensive final examinations. Strengthen your knowledge, improve diagnostic accuracy, and build confidence with this comprehensive blood banking exam preparation resource.

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Modern Blood Banking & Transfusion - Denise
Harmening Practices Exam Questions &
Answers | Complete Practice Test | Latest
2026–2027




** Expert-Verified Explanation
** All Questions with Verified Answer
** Guaranteed Pass
** 100% Correct Answers | Graded A+

,What is the maximum volume of blood that can be c. 525 mL
collected from a 110-lb donor, including samples for
processing?

a. 450 mL
b. 500 mL
c. 525 mL
d. 550 mL


When RBCs are stored, there is a "shift to the left." This b. Hemoglobin oxygen affinity increases, owing to a decrease in 2,3-DPG.
means:

a. Hemoglobin oxygen affinity increases, owing to an
increase in 2,3-DPG.

b. Hemoglobin oxygen affinity increases, owing to a
decrease in 2,3-DPG.

c. Hemoglobin oxygen affinity decreases, owing to a
decrease in 2,3-DPG.

d. Hemoglobin oxygen affinity decreases, owing to an
increase in 2,3-DPG.


Which of the following anticoagulant preservatives d. CPDA-1
provides a storage time of 35 days at 1°C to 6°C for units
of whole blood and prepared RBCs if an additive solution
is not added?

a. ACD-A
b. CP2D
c. CPD
d. CPDA-1


What are the current storage time and storage c. 5 days at 20°C to 24°C
temperature for platelet concentrates and apheresis
platelet components? With continuous agitation

a. 5 days at 1°C to 6°C
b. 5 days at 24°C to 27°C
c. 5 days at 20°C to 24°C
d. 7 days at 22°C to 24°C


Maintain vascular integrity Role of platelets
Initial arrest of bleeding
Stabilization of hemostatic plug


Factors influencing platelet metabolism and function in a d. Fibrinogen concentration
closed system except:

a. Total platelet count
b. Duration of storage
c. Temperature of storage
d. Fibrinogen concentration


Platelet components are stored up fo 5 days at 20-24'C d. 24 hrs
with continuous agitation. When necessary during
shipping, platelets can be stored without agitation for up Platelets stored ar (1-6'C): 2 days
to _____ (at 20 to 24'C) during a 5-day storage period

a. 4 hrs
b. 6 hrs
c. 12 hrs
d. 24 hrs


If a platelet bag is broken or opened, the platelets must a. 4 hrs
be transfused within _____ when stored at 20 to 24'C

a. 4 hrs
b. 24 hrs
c. 5 days
d. 7 days

, What is the minimum number of platelets required in a d. 5.5 x 10^10
platelet concentrate prepared from whole blood by
centrifugation (90% of sampled units)?

a. 5.5 x 10^11
b. 3 x 10^10
c. 3 x 10^11
d. 5.5 x 10^10


RBCs can be frozen for: d. 10 years


a. 12 months.
b. 1 year.
c. 5 years.
d. 10 years.


What is the minimum number of platelets required in an a. 3 x 10^11
apheresis component (90% of the sampled units)?

a. 3 x 10^11
b. 4 x 10^11
c. 2 x 10^11
d. 3.5 x 10^11


Whole blood and RBC units are stored at what a. 1°C to 6°C
temperature?

a. 1°C to 6°C
b. 20°C to 24°C
c. 37°C
d. 24°C to 27°C


Additive solutions are approved for storage of red blood b. 42
cells for how many days?

a. 21
b. 42
c. 35
d. 7


One criterion used by the FDA for approval of new d. 75%
preservation solutions and storage containers is an
average 24-hour post-transfusion RBC survival of more
than:

a. 50%.
b. 60%.
c. 65%.
d. 75%.


What is the lowest allowable pH for a platelet component d. 6.2
at outdate?

a. 6
b. 5.9
c. 6.8
d. 6.2


Frozen and thawed RBCs processed in an open system c. 24 hours
can be stored for how many days/hours?

a. 3 days
b. 6 hours
c. 24 hours
d. 15 days


What is the hemoglobin source for hemoglobin-based c. Both bovine and human hemoglobins
oxygen carriers in advanced clinical testing?

a. Only bovine hemoglobin
b. Only human hemoglobin
c. Both bovine and human hemoglobins
d. None of the above

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