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COMSAE Form 107 Study Guide (2026–2027) | COMLEX-USA Board Exam Prep with Questions and Verified Answers with Rationales | Grade A+

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Prepare for the COMLEX-USA Level 2-CE examination with this comprehensive COMSAE Form 107 Study Guide featuring Questions and Verified Answers with Rationales. This resource includes realistic multiple-choice practice questions covering high-yield clinical topics tested on COMLEX-USA Level 2, including internal medicine, family medicine, pediatrics, obstetrics and gynecology, psychiatry, surgery, emergency medicine, preventive medicine, osteopathic principles and practice (OPP/OMM), pharmacology, ethics, patient safety, diagnostic reasoning, evidence-based clinical management, and multidisciplinary patient care. Ideal for osteopathic medical students preparing for COMSAE self-assessments, COMLEX-USA Level 2-CE, clerkship examinations, and board certification, this study guide helps reinforce essential clinical concepts, strengthen diagnostic reasoning, improve exam readiness, and build confidence for board examination success.

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COMSAE Form 107 Study Guide
2026–2027 | COMLEX-USA Board
Exam Prep




** Expert-Verified Explanation
** Questions with Verified Answer
** New Edition |Updated
** Guaranteed Pass
** 100% Correct Answers | Graded A+

,DMARD drug for UC/Crohns/RA sulfasalazine




pulmonary effects of CF chronic bronchitis and bronchiectasis




osteoporosis affects what parts of bone? (spongy and ) trabecular bone mass loss




imipramine TCA

SE: Tri-Cs
convulsions
coma
cardiotox

antichol effects- confusion in elderly; (acute glaucoma and orthostatic
hypotension- block alpha1)


viscerosomatic visceral disease --> somatic finding




loratidine vs ranitidine loratidine: 2nd gen H1 blocker, doesnt cross BBB --> less sedating

ranitidine: H2 receptor antagonist (like cimetidine)


cells w RBCs inside entaemoba histolytica




which type of pneumothorax causes tracheal deviation to tension
the contra side?



intracerebral hemorrhage adjacent to a lesion that AVM arteriovenous malformation
contains a tangle of numerous tortuous vessels



cavernous hemangioma benign tumor of liver, A/W VHL




anti-HepB surface antibody is only present in what pop recovered or immunized

not in chronic or


proctalgia fugax levator ani syndrome




fasciculus is UMN or LMN lesion? LMN




ectopic gastric tissue meckels diverticulum

can also have ectopic pancreatic tissue

remnant of vitelline duct

,antibodies in hashimotos attacks thyroid peroxidase or antithyroglobulin

enlarged non tender thyroid


2 factors that influence starling curve x axis- preload (EDV)
y axis- stroke volume or CO



treatment for fibromyalgia TCA, SNRIs anticonvulsants




what blocks NE reuptake? TCA or SNRIs




possible complication of pagets bone disease osteocarcoma




what does Hct tell you? ratio of volume of RBCs compared to total blood volume




probenecid inhibits reabsoprtion of uric acid in PCT
- also inhibits secretion of PCN
- can ppt uric acid calculi


2 causes of SCID ADA deficiency
(adenosine deaminase required for degradation of adenosim and
deoxyadenosine
- in ADA deficiency, high levels of dATP --> toxicity in lymphocytes --> SCID

hypoplastic thymus


lithiums effects on urination inhibits vasopression/ADH --> increased urinary frequency




infertility drug that can result in multiple fetuses clomiphene (clones- multiple babies)

antagonist at estrogen R in hypothalamus (thus inhibits normal negative
feedback)

upregulates LH and FSH release from pituitary --> ovulation

used to treat PCOS but can cause ovarian enlargement, multiple fetuses


AFP levels in down syndrome low




GI malformation A/W down syndrome Hirschprungs- congenital aganglionic megacolon

defective relaxation and peristalsis of rectum and distal sigmoid colon

failure to pass meconium, empty rectal vault, megacolon


myasthenia gravis associations thymoma, thymic hyperplasia

ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders, respiration


tx for tinea azoles

, beta blockers for asthma none- even beta 1s can be nonselective at higher doses




what kind of teratogenic effects are seen w ACE/ARBs fetal renal agenesis




stones bones groans moans psych overtones high Ca or PTH




PTH is made by what cells? chief cells of parathyroid gland




PTH inhibits reabsorption of phosphate where? PO4- proximal tubule
increases calcium resorption where? ca- DCT



anterior innominate rotation means tight hip flexors or extensor- hamstrings
extensors?



thoracic CS E SaRa




most common cause of cellultis staph aureus, strep pyogenes




FPR- direct or indirect? active or passive? indirect- place them in position of diagnosis
passive



cant treat kid w tetracycline so what do you give? amoxicillin




which Heps are there currently vaccines for? A and B (and so by virtue, also D)




why does Hep D need Hep B? Hep D utilizes the HBV surface antigen as its envelope?




most common hepatitis A/W IVDA in the US hep c




roseola 4 day high fever
then rash on the trunk (spares face)

affects babies up to 2 years

HHV6- affects CD4 helper cells and kills them off

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