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NGN ATI RN COMPREHENSIVE PREDICTOR 2026 RETAKE EXAM 350 UNIQUE MULTIPLE CHOICE QUESTIONS WITH DETAILED RATIONALES

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This comprehensive ATI RN Comprehensive Predictor 2026 Retake Exam study guide features 350 unique, multiple-choice practice questions with detailed rationales covering every essential nursing content area for NCLEX-RN® and ATI proctored exam success, including medical-surgical nursing (cardiovascular, respiratory, neurological, renal, endocrine, gastrointestinal, musculoskeletal, hematological, oncological disorders), pharmacology and medication administration (medication calculations, drug interactions, side effects, routes of administration, insulin therapy, anticoagulants, antibiotics, cardiac medications, psychiatric medications), maternity and women's health (prenatal care, labor and delivery, postpartum care, newborn assessment, complications of pregnancy, breastfeeding, contraception), pediatric nursing (growth and development, pediatric assessment, common childhood illnesses, immunizations, pediatric emergencies, developmental milestones), mental health nursing (psychiatric disorders, therapeutic communication, psychopharmacology, crisis intervention, suicide prevention, substance abuse, personality disorders), leadership, management, and ethical/legal issues (delegation, prioritization, client rights, informed consent, HIPAA, advance directives, DNR orders, conflict resolution, quality improvement), community and public health (epidemiology, disaster preparedness, health promotion, disease prevention, vulnerable populations, cultural competence, environmental health), and Next Generation NCLEX (NGN) clinical judgment case studies (prioritization, delegation, clinical reasoning, patient scenarios, prioritization frameworks). Each question includes the correct answer and a detailed rationale explaining the underlying nursing principles, clinical reasoning, and evidence-based interventions, making this the ultimate resource for ATI RN Comprehensive Predictor retake candidates, NCLEX-RN® test-takers, nursing students, and graduate nurses seeking to pass the ATI comprehensive exam and the NCLEX.

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NGN ATI RN COMPREHENSIVE PREDICTOR
2026 RETAKE EXAM 350 UNIQUE MULTIPLE-
CHOICE QUESTIONS WITH DETAILED
RATIONALES

---


SECTION 1: MEDICAL-SURGICAL NURSING (Questions 1-50)


---


Question 1
A nurse is caring for a client with heart failure who reports dyspnea, crackles in the
lung bases, and 2+ pitting edema. Which intervention should the nurse implement
first?


A) Administer furosemide as prescribed
B) Place the client in High-Fowler's position
C) Check oxygen saturation
D) Restrict oral fluid intake


Correct Answer: B


Rationale: The priority is to relieve dyspnea. High-Fowler's position maximizes lung
expansion and improves ventilation. While oxygen and diuretics are important,

,positioning is the immediate nursing intervention that can be implemented without
waiting for prescriptions or additional assessments.


---


Question 2
A client with diabetes mellitus is scheduled for a fasting blood glucose test. The
nurse should instruct the client to:


A) Eat a light breakfast before the test
B) Drink only water for 8 hours before the test
C) Take the morning dose of insulin as usual
D) Avoid all food and fluids for 12 hours


Correct Answer: B


Rationale: Fasting means no caloric intake for 8-12 hours. Water is permitted to
prevent dehydration. Insulin should be withheld until after the test to prevent
hypoglycemia during the fasting period.


---


Question 3
A nurse is assessing a client with pneumonia. Which finding requires immediate
intervention?


A) Temperature of 38.3°C (101°F)
B) Productive cough with green sputum

,C) Respiratory rate of 28/min with SpO₂ of 88%
D) Chest discomfort with deep breathing


Correct Answer: C


Rationale: An SpO₂ of 88% indicates significant hypoxemia requiring immediate
oxygen therapy. The ABC framework (Airway, Breathing, Circulation) prioritizes
respiratory compromise. While the other findings are concerning, they do not
represent immediate life-threatening conditions.


---


Question 4
A nurse is caring for a client with an arteriovenous fistula for hemodialysis. Which
finding should the nurse report to the provider?


A) Thrill upon palpation
B) Absence of a bruit
C) Warmth over the fistula site
D) Slight edema around the site


Correct Answer: B


Rationale: Absence of a bruit indicates possible thrombosis or occlusion of the
fistula, which requires immediate intervention. A thrill and bruit are expected
findings indicating patency. Warmth and slight edema may be expected post-
creation but should be monitored.


---

, Question 5
A client is receiving a blood transfusion and develops chills, fever, and lower back
pain. What is the nurse's priority action?


A) Slow the transfusion rate
B) Administer acetaminophen
C) Stop the transfusion immediately
D) Notify the provider


Correct Answer: C


Rationale: These findings suggest a hemolytic transfusion reaction. The priority
action is to stop the transfusion immediately to prevent further complications. After
stopping the transfusion, the nurse should maintain IV access with normal saline,
notify the provider, and send the blood bag and tubing to the blood bank for
analysis.


---


Question 6
A nurse is preparing to insert a nasogastric tube. After inserting the tube, which
method is the most reliable to confirm placement?


A) Auscultating for air over the epigastric area
B) Measuring the pH of gastric aspirate
C) X-ray confirmation
D) Observing for coughing or gagging

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