ANPS 8005 2 Questions with CORRECT Answers
Question:
What are Pharmacokinetics?
Answer:
What our body does to drugs
Question:
What is bioavailability?
Answer:
Fraction of administered drug that reaches systemic circulation to reach the intended
target after absorption barriers | Ex- IV is 1 or 100% others are fractions
Question:
What effects bioavailability?
Answer:
Route, formulation of the drug, drug | characteristics, patient characteristics
Question:
Is highly lipophilic / fat soluble drugs
Answer:
Lipophilic - fat more penatratable or hydrophilic / | water loving drugs
Question:
What is first pass metabolism
Answer:
Phenomenon in which the liver metabolizes some of a drug before it can circulate
through the body, particularly when the drug has been taken orally. Can activate
fraction of what was ingested or active a pro drug
, Question:
What are 4 ways a drug can be absorbed?
Answer:
Enteral (oral- but has 1st pass metabolism) parenteral (rapid, no first pass metabolism,
irreversible- sq, IM, IV, intrathecal) mucus membranes- (sl, ocular, rectal - few meds)
transdermal (has to be highly lipophilic & slow delivery but no 1st pass metabolism
required)
Question:
What is Distribution, goal of it & 3 components that affect it?
Answer:
once medications are absorbed it is how they are distributed- which varies pending
properties of blood & body tissuesgoal is to get drug molecules to the target so drug can
work - some stored in bone & fat volume of distribution, blood brain barrier-
hydrophobic drugs or intrasequeal, plasm protein- albumin - protein bound=low volume
of distribution = valproic acid w/ free concentration could lead to toxicity
Question:
Distribution- how do medications
Answer:
Brain has tight junctions to prevent passive work with the blood brain barrier? diffusion
of most drugs | Drugs must be highly lipophilic or use existing | proteins - to protect the
cns- can use intrathecal to bypass
Question:
Distribution- what is the affects of plasma protein binding?
Answer:
Can change / determines how much of the drug reaches the target
Question:
How can it affect distribution?
Answer:
A drug that is bound is not available to cross membranes staying in circulatory system &
does not arrive to its destination Albumin can be a marker - low albumin can cause
more free concentration leading to toxicity Also if you have 2 highly bound protein drugs
they may compete for binding & push one off leading to higher concentrations on one
Question:
What are Pharmacokinetics?
Answer:
What our body does to drugs
Question:
What is bioavailability?
Answer:
Fraction of administered drug that reaches systemic circulation to reach the intended
target after absorption barriers | Ex- IV is 1 or 100% others are fractions
Question:
What effects bioavailability?
Answer:
Route, formulation of the drug, drug | characteristics, patient characteristics
Question:
Is highly lipophilic / fat soluble drugs
Answer:
Lipophilic - fat more penatratable or hydrophilic / | water loving drugs
Question:
What is first pass metabolism
Answer:
Phenomenon in which the liver metabolizes some of a drug before it can circulate
through the body, particularly when the drug has been taken orally. Can activate
fraction of what was ingested or active a pro drug
, Question:
What are 4 ways a drug can be absorbed?
Answer:
Enteral (oral- but has 1st pass metabolism) parenteral (rapid, no first pass metabolism,
irreversible- sq, IM, IV, intrathecal) mucus membranes- (sl, ocular, rectal - few meds)
transdermal (has to be highly lipophilic & slow delivery but no 1st pass metabolism
required)
Question:
What is Distribution, goal of it & 3 components that affect it?
Answer:
once medications are absorbed it is how they are distributed- which varies pending
properties of blood & body tissuesgoal is to get drug molecules to the target so drug can
work - some stored in bone & fat volume of distribution, blood brain barrier-
hydrophobic drugs or intrasequeal, plasm protein- albumin - protein bound=low volume
of distribution = valproic acid w/ free concentration could lead to toxicity
Question:
Distribution- how do medications
Answer:
Brain has tight junctions to prevent passive work with the blood brain barrier? diffusion
of most drugs | Drugs must be highly lipophilic or use existing | proteins - to protect the
cns- can use intrathecal to bypass
Question:
Distribution- what is the affects of plasma protein binding?
Answer:
Can change / determines how much of the drug reaches the target
Question:
How can it affect distribution?
Answer:
A drug that is bound is not available to cross membranes staying in circulatory system &
does not arrive to its destination Albumin can be a marker - low albumin can cause
more free concentration leading to toxicity Also if you have 2 highly bound protein drugs
they may compete for binding & push one off leading to higher concentrations on one
