CHM 451 EXAM 1_110 QUESTIONS WITH VERIFIED ANSWERS,100%CORRECT

CHM 451 EXAM 1_110 QUESTIONS WITH
VERIFIED ANSWERS
What drug does to the body
MOA


Determine drug classification - CORRECT ANSWER Pharmacodynamics


State legislatures through licensing boards - CORRECT ANSWER Primary
Organizations That Control Privilege of Prescribing Drugs


Pass exams
Pay fees
Education requirements - CORRECT ANSWER Criteria Required For Privilege of
Prescribing


What body does to the drug
ADME - CORRECT ANSWER Pharmacokinetics


Different responses to drug based on genetic background - CORRECT ANSWER
Pharmacogenetics


Genetic techniques to find new drug - CORRECT ANSWER Pharmacogenomics


1) Program selection

,2) ID and validation of drug target
3) Assay
4) ID lead compound
5) Lead optimization
6) ID drug candidate
7) Clinical trials
8) Release drug
9) Follow-up monitoring
10) $$$ - CORRECT ANSWER Steps of Modern Drug Research


Things to consider:
medical need
current therapy available
competitor activity
commercial opportunity - CORRECT ANSWER Program Selection


Drug targets:
G-proteins (45%)
enzymes (28%)
hormones (11%)
ion channels (5%)
nuclear receptors (2%)

, Drug target must be critical to disease process - CORRECT ANSWER ID and
Validation of Drug Target


Check if compound biologically active


Hits -> compound active in assay
Leads -> compound active in animal model - CORRECT ANSWER Assay


Determine synthetic routes for SAR and optimize molecular structure for drug
activity


Where compound comes from:
natural products (plants/bacteria/animals - 61%)
rational drug design (21%)
biological peptides (14%)
vaccines (4%) - CORRECT ANSWER Lead Optimization


Phase I:
30-100 healthy volunteers
determine drug safety


Phase II:
100-300 diseased people
single-blind study