Actual ATI RN Pharmacology Exam Retake 2023 with NGN
Latest 2025 Version — 70 Real Retake Exam Questions and
100% ATI Approved Answers.
The following 70 questions are compiled from actual ATI RN Pharmacology Proctored
Retake Exam materials and formatted in the NGN (Next Generation NCLEX) style. These
questions reflect the 2023 exam content updated for the 2025/2026 testing cycle.
SECTION 1: Pain Management & Opioids (Questions 1-6)
Question 1
A nurse is caring for a client who has breast cancer and reports pain 1 hour after
administration of prescribed morphine 10 mg IV. Which of the following medications
should the nurse expect to administer?
A. Naloxone IV
B. Morphine tablet
C. Lidocaine patch
D. Fentanyl transmucosal
Answer: A. Naloxone IV
Rationale: Morphine is an opioid agonist. If a client continues to report pain 1 hour
after IV morphine administration, the nurse should assess for signs of opioid toxicity or
inadequate pain relief. Naloxone is an opioid antagonist used to reverse respiratory
depression and other effects of opioid overdose. IV administration provides the fastest
onset.
Question 2
A nurse is providing teaching to a client who has a new prescription for clozapine. Which
of the following statements should the nurse include in the teaching?
A. Notify your provider if you develop a fever while taking this medication
B. Diarrhea is a common adverse effect of this medication
C. Ringing in the ears is an expected adverse effect of this medication
D. You might experience weight loss while taking this medication
,Answer: A. Notify your provider if you develop a fever while taking this
medication
Rationale: Clozapine can cause agranulocytosis, a potentially fatal decrease in white
blood cells. Fever, sore throat, and other signs of infection should be reported
immediately. Weight gain, not weight loss, is common with clozapine.
Question 3
A nurse is assessing a client after administering phenytoin IV bolus for a seizure. Which
of the following findings should the nurse identify as an adverse effect of the
medication?
A. Bradycardia
B. Red man syndrome
C. Hypoglycemia
D. Hypotension
Answer: D. Hypotension
Rationale: Rapid IV administration of phenytoin can cause hypotension and cardiac
dysrhythmias. The medication should be administered no faster than 50 mg/min. Red
man syndrome is associated with vancomycin.
Question 4
A client who has active TB and is taking rifampin reports that his urine and sweat have
developed a red-orange tinge. Which of the following actions should the nurse take?
A. Document this as an expected finding
B. Prepare the client for dialysis
C. Check the client's liver functions
D. Instruct the client to increase his fluid intake
Answer: A. Document this as an expected finding
Rationale: Rifampin causes a harmless red-orange discoloration of body fluids
including urine, sweat, tears, and saliva. The nurse should document this as an expected
finding and reassure the client.
Question 5
, A home health nurse is visiting a client who has heart failure and a prescription for
furosemide. The nurse identifies that the client has gained 2.5 kg since the last visit 2
days ago. Which of the following actions should the nurse take first?
A. Notify the provider of the client's weight gain
B. Determine medication adherence by the client
C. Encourage the client to dangle the legs while sitting in a chair
D. Teach the client about food low in sodium
Answer: A. Notify the provider of the client's weight gain
Rationale: A weight gain of 2.5 kg (approximately 5.5 lbs) in 2 days indicates significant
fluid retention and worsening heart failure. The priority action is to notify the provider
immediately.
Question 6
A nurse is caring for a client who is taking tamoxifen to treat breast cancer. The nurse
should identify which of the following manifestations as an adverse effect of this
medication?
A. Constipation
B. Hot flashes
C. Urinary frequency
D. Tinnitus
Answer: B. Hot flashes
Rationale: Tamoxifen, a selective estrogen receptor modulator (SERM), commonly
causes hot flashes as an adverse effect. Other adverse effects include vaginal discharge,
menstrual irregularities, and increased risk of thromboembolic events.
SECTION 2: Cardiovascular Medications (Questions 7-16)
Question 7
A nurse is assessing a client who reports taking over-the-counter antacids. Which of the
following findings should the nurse identify as a manifestation of hypercalcemia?
Latest 2025 Version — 70 Real Retake Exam Questions and
100% ATI Approved Answers.
The following 70 questions are compiled from actual ATI RN Pharmacology Proctored
Retake Exam materials and formatted in the NGN (Next Generation NCLEX) style. These
questions reflect the 2023 exam content updated for the 2025/2026 testing cycle.
SECTION 1: Pain Management & Opioids (Questions 1-6)
Question 1
A nurse is caring for a client who has breast cancer and reports pain 1 hour after
administration of prescribed morphine 10 mg IV. Which of the following medications
should the nurse expect to administer?
A. Naloxone IV
B. Morphine tablet
C. Lidocaine patch
D. Fentanyl transmucosal
Answer: A. Naloxone IV
Rationale: Morphine is an opioid agonist. If a client continues to report pain 1 hour
after IV morphine administration, the nurse should assess for signs of opioid toxicity or
inadequate pain relief. Naloxone is an opioid antagonist used to reverse respiratory
depression and other effects of opioid overdose. IV administration provides the fastest
onset.
Question 2
A nurse is providing teaching to a client who has a new prescription for clozapine. Which
of the following statements should the nurse include in the teaching?
A. Notify your provider if you develop a fever while taking this medication
B. Diarrhea is a common adverse effect of this medication
C. Ringing in the ears is an expected adverse effect of this medication
D. You might experience weight loss while taking this medication
,Answer: A. Notify your provider if you develop a fever while taking this
medication
Rationale: Clozapine can cause agranulocytosis, a potentially fatal decrease in white
blood cells. Fever, sore throat, and other signs of infection should be reported
immediately. Weight gain, not weight loss, is common with clozapine.
Question 3
A nurse is assessing a client after administering phenytoin IV bolus for a seizure. Which
of the following findings should the nurse identify as an adverse effect of the
medication?
A. Bradycardia
B. Red man syndrome
C. Hypoglycemia
D. Hypotension
Answer: D. Hypotension
Rationale: Rapid IV administration of phenytoin can cause hypotension and cardiac
dysrhythmias. The medication should be administered no faster than 50 mg/min. Red
man syndrome is associated with vancomycin.
Question 4
A client who has active TB and is taking rifampin reports that his urine and sweat have
developed a red-orange tinge. Which of the following actions should the nurse take?
A. Document this as an expected finding
B. Prepare the client for dialysis
C. Check the client's liver functions
D. Instruct the client to increase his fluid intake
Answer: A. Document this as an expected finding
Rationale: Rifampin causes a harmless red-orange discoloration of body fluids
including urine, sweat, tears, and saliva. The nurse should document this as an expected
finding and reassure the client.
Question 5
, A home health nurse is visiting a client who has heart failure and a prescription for
furosemide. The nurse identifies that the client has gained 2.5 kg since the last visit 2
days ago. Which of the following actions should the nurse take first?
A. Notify the provider of the client's weight gain
B. Determine medication adherence by the client
C. Encourage the client to dangle the legs while sitting in a chair
D. Teach the client about food low in sodium
Answer: A. Notify the provider of the client's weight gain
Rationale: A weight gain of 2.5 kg (approximately 5.5 lbs) in 2 days indicates significant
fluid retention and worsening heart failure. The priority action is to notify the provider
immediately.
Question 6
A nurse is caring for a client who is taking tamoxifen to treat breast cancer. The nurse
should identify which of the following manifestations as an adverse effect of this
medication?
A. Constipation
B. Hot flashes
C. Urinary frequency
D. Tinnitus
Answer: B. Hot flashes
Rationale: Tamoxifen, a selective estrogen receptor modulator (SERM), commonly
causes hot flashes as an adverse effect. Other adverse effects include vaginal discharge,
menstrual irregularities, and increased risk of thromboembolic events.
SECTION 2: Cardiovascular Medications (Questions 7-16)
Question 7
A nurse is assessing a client who reports taking over-the-counter antacids. Which of the
following findings should the nurse identify as a manifestation of hypercalcemia?
