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BSN 266 HESI Exam (Latest 2026/2027 Update) | Q&A with Verified Answers and Detailed Rationales | Medical-Surgical Nursing, Prioritization, Pharmacology | A+ Graded | Nightingale College

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INSTANT PDF DOWNLOAD – This comprehensive study guide is designed for the BSN 266 HESI Exam at Nightingale College (Latest 2026/2027 Update), featuring 200+ verified practice questions with correct answers and detailed rationales. This resource covers all core content areas tested on the HESI 266 exam, including medical-surgical nursing (cardiovascular, respiratory, neurological, gastrointestinal, renal, endocrine), pharmacology, and clinical prioritization (ABCs, Maslow's Hierarchy). Key topics include compartment syndrome, chest tube management, cirrhosis, electrolyte imbalances, and emergency interventions for septic shock and stroke. Practice Questions & Rationales Q1: A client with septic shock is receiving norepinephrine at 20 mcg/min via peripheral IV. The nurse notes extravasation with blanching and swelling at the insertion site. Which intervention should the nurse implement first? Answer: Administer phentolamine 5-10 mg diluted in 10 mL normal saline as local subcutaneous infiltration. Rationale: Extravasation of vasopressors like norepinephrine can cause severe tissue ischemia and necrosis. The first-line treatment is local infiltration of phentolamine, an alpha-adrenergic blocker, to reverse vasoconstriction and prevent tissue damage. Warm compresses may worsen injury by increasing metabolic demand. Q2: A client with a chest tube connected to a water-seal drainage system has continuous bubbling in the water-seal chamber. Which is the most likely cause? Answer: An air leak in the system. Rationale: Continuous bubbling in the water-seal chamber indicates an air leak in the system, such as a disconnection, loose connection, or leak in the tubing or at the insertion site. Normal tidaling is intermittent and corresponds with respirations. Q3: A client with cirrhosis presents with 4+ pitting edema and massive ascites. Which mechanism contributes to edema and ascites in cirrhosis? Answer: Hypoalbuminemia resulting in decreased colloidal oncotic pressure. Rationale: In cirrhosis, the liver's decreased synthesis of albumin leads to hypoalbuminemia. Albumin maintains colloidal oncotic pressure; when decreased, fluid leaks out of blood vessels, resulting in edema and ascites. Q4: A client on a thiazide diuretic has a serum potassium level of 3.0 mEq/L. The nurse anticipates which change in prescription? Answer: A potassium supplement will be prescribed. Rationale: This client's potassium level is below the normal range (3.5-5.5 mEq/L). Thiazide diuretics often result in potassium loss, so a potassium supplement needs to be prescribed. Q5: A client with a completed ischemic stroke has a blood pressure of 180/90 mm Hg. Which action should the nurse implement? Answer: Give an antihypertensive medication. Rationale: Completed strokes usually produce neurologic deficits within an hour, and the client's current elevated blood pressure requires antihypertensive medication to prevent further damage. Vertical Keywords / Tags BSN 266 HESI 2026 Nightingale College HESI Exam Prep Medical Surgical Nursing HESI Questions Pharmacology HESI Review Guide HESI Exit Exam Practice Test Compartment Syndrome Management Norepinephrine Extravasation Phentolamine Chest Tube Water Seal Bubbling Cirrhosis Ascites Hypoalbuminemia Thiazide Diuretic Hypokalemia Ischemic Stroke Hypertension A+ Grade BSN HESI Study Guide

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Nightingale College




ISEH · 662 NSB
★ ★



N School of Nursing
EST. 2004
C O M M I T T E D T O E X C E L L E N C E I N N U R S I N G E D U C AT I O N



BSN 266 HESI
CO M P R E H E N S I V E N U RS I N G P RACT I C E A SS E SS M E N T

INSTITUTION Nightingale College PROGRAM Bachelor of Science in Nursing —
HESI Review
COURSE CODE BSN 266 COURSE TITLE Comprehensive Nursing Practice
ACADEMIC YEAR EXAM TITLE BSN 266 HESI
TOTAL QUESTIONS 50 Questions FORMAT Multiple Choice — Select the
Single Best Answer


EXAMINATION INSTRUCTIONS
▸ Select the single best answer for each question unless otherwise instructed.
▸ Medical-surgical nursing, pharmacology, and pathophysiology are all testable content.
▸ Clinical reasoning and priority-setting are emphasized.
▸ Correct answers and clinical rationales appear below each question for board review purposes.
▸ All clinical data reflects current evidence-based practice guidelines.

, SECTION I — COMPREHENSIVE NURSING PRACTICE Questions 1 – 50

1. A client who underwent cardiac stent placement four days ago arrives to the emergency
department reporting a sudden onset of chest pressure and shortness of breath. Which
action should the nurse take next?
A. Listen for extra heart sounds, murmurs, and rhythm with the bell of the stethoscope
B. Evaluate upper and lower extremities for perfusion, pulse volume, and pitting edema
C. Verify troponin level assessments are scheduled every 3-6 hours for a series of three
D. Obtain a 12-lead electrocardiogram and begin continuous cardiac monitoring
CORRECT ANSWER D — Obtain a 12-lead electrocardiogram and begin continuous cardiac
monitoring
RATIONALE A client with recent cardiac stent placement presenting with chest pressure and
shortness of breath is at risk for stent thrombosis or acute coronary syndrome.
The priority is to obtain a 12-lead ECG and begin continuous cardiac monitoring
to assess for ischemic changes.


2. A client with type 2 diabetes mellitus arrives to the clinic reporting episodes of weakness
and palpitations. Which finding should the nurse recognize as a possible complication?
A. Anxiety and sighing
B. Myalgia in wrists and hands
C. Hyperactive bowel sounds
D. Dark yellow urine
CORRECT ANSWER B — Myalgia in wrists and hands
RATIONALE Myalgia in wrists and hands may indicate diabetic neuropathy or other
complications of diabetes. This finding should be evaluated further to determine
the cause.

, 3. While completing a health assessment for a client with migraine headaches, the nurse
assesses bilateral weakness in the client's hand grips. The client reports joint pain and
trouble twisting a door knob due to weakness. Which action should the nurse take in
response to these findings?
A. Implement fall precautions to reduce the client's risk of injury
B. Explain that relief of the migraine pain will reduce related symptoms
C. Gather additional assessment data about the pain and weakness
D. Consult with the occupational therapist for a functional assessment
CORRECT ANSWER C — Gather additional assessment data about the pain and weakness
RATIONALE The nurse should gather additional assessment data about the pain and
weakness to better understand the client's condition and to determine if there is
an underlying issue or if the symptoms are related to the migraine headaches.


4. A client who has developed acute kidney injury (AKI) due to aminoglycoside antibiotics
has moved from the oliguric phase to the diuretic phase of AKI. Which parameters are
most important for the nurse to plan to carefully monitor?
A. Uremic irritation of mucous membranes and skin surfaces
B. Hypovolemia and electrocardiographic (ECG) changes
C. Side effects of total parenteral nutrition (TPN) and Intralipids
D. Elevated creatinine and blood urea nitrogen (BUN)
CORRECT ANSWER B — Hypovolemia and electrocardiographic (ECG) changes
RATIONALE During the diuretic phase of AKI, the client may experience increased urine
output, which can lead to hypovolemia and electrolyte imbalances. Monitoring
for hypovolemia and ECG changes can help detect any complications or
worsening of the client's condition.

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