NR565 ADVANCED PHARMACOLOGY MIDTERM EXAM STUDY GUIDE | PRACTICE QUESTIONS
& ANSWERS | COMPREHENSIVE REVIEW 2026/2027
Schedule 3-5 drugs - correct answer ✔✔Drugs that APRNs can prescribe
Prescriptive authority regulation - correct answer ✔✔Determined by State Boards of Nursing,
Medicine, and Pharmacy
Limited prescriptive authority impact - correct answer ✔✔Leads to fewer treatment options for
patients, requiring them to find providers with authority
Key responsibilities of prescribing - correct answer ✔✔Understanding prescribed drugs, their
effects, contraindications, and ensuring correct dosages
BSCRAP GPS Incudes Rage - correct answer ✔✔Acronym for CYP450 enzyme inducers:
Barbiturates, St. John's Wort, Carbamazepine, Rifampin, Alcohol, Phenytoin, Griseofulvin,
Phenobarbital, Sulfonylureas
Bioavailability - correct answer ✔✔Amount of active drug reaching systemic circulation from
administration site
Reasons for medication nonadherence - correct answer ✔✔Include forgetfulness, lack of
planning, cost, dissatisfaction, and altered dosing
IM administration in neonates and infants - correct answer ✔✔Absorption is slow in neonates
due to low muscle blood flow; absorption becomes rapid in early infancy
Oral administration in neonates/infants - correct answer ✔✔Gastric emptying time is prolonged
and irregular in early infancy, affecting drug absorption
, Dosage determination for pediatric patients - correct answer ✔✔Based on body surface area
(BSA) calculation
Guiding principles for prescribers - correct answer ✔✔Steps include defining the problem,
setting therapeutic objectives, choosing treatment, verifying its suitability, starting treatment,
giving information, and monitoring treatment
CYP450 inhibitors - correct answer ✔✔Examples include Valproate, Isoniazid, Sulfonamides,
Amiodarone, Chloramphenicol, Ketoconazole, Grapefruit juice, Quinidine
Pharmacokinetics and pharmacodynamics - correct answer ✔✔Basis for prescribing decisions,
considering drug interactions and effects on target receptors
Beer's Criteria - correct answer ✔✔Tool identifying inappropriate medication use in older
adults, cautioning against certain drugs and interactions
Impacts of polypharmacy - correct answer ✔✔Include adverse drug events, increased
healthcare interactions, cognitive impairment, reduced adherence, falls, and mortality
CYP450 inhibitors function - correct answer ✔✔They decrease medication metabolism
CYP450 inhibitors consequences - correct answer ✔✔May cause toxicity if enzymes are inactive
or ineffectiveness if enzymes are overactive
Poor metabolism phenotype - correct answer ✔✔Occurs when CYP2D6 alleles have inactivating
mutations, leading to enzyme synthesis with impaired or no activity
& ANSWERS | COMPREHENSIVE REVIEW 2026/2027
Schedule 3-5 drugs - correct answer ✔✔Drugs that APRNs can prescribe
Prescriptive authority regulation - correct answer ✔✔Determined by State Boards of Nursing,
Medicine, and Pharmacy
Limited prescriptive authority impact - correct answer ✔✔Leads to fewer treatment options for
patients, requiring them to find providers with authority
Key responsibilities of prescribing - correct answer ✔✔Understanding prescribed drugs, their
effects, contraindications, and ensuring correct dosages
BSCRAP GPS Incudes Rage - correct answer ✔✔Acronym for CYP450 enzyme inducers:
Barbiturates, St. John's Wort, Carbamazepine, Rifampin, Alcohol, Phenytoin, Griseofulvin,
Phenobarbital, Sulfonylureas
Bioavailability - correct answer ✔✔Amount of active drug reaching systemic circulation from
administration site
Reasons for medication nonadherence - correct answer ✔✔Include forgetfulness, lack of
planning, cost, dissatisfaction, and altered dosing
IM administration in neonates and infants - correct answer ✔✔Absorption is slow in neonates
due to low muscle blood flow; absorption becomes rapid in early infancy
Oral administration in neonates/infants - correct answer ✔✔Gastric emptying time is prolonged
and irregular in early infancy, affecting drug absorption
, Dosage determination for pediatric patients - correct answer ✔✔Based on body surface area
(BSA) calculation
Guiding principles for prescribers - correct answer ✔✔Steps include defining the problem,
setting therapeutic objectives, choosing treatment, verifying its suitability, starting treatment,
giving information, and monitoring treatment
CYP450 inhibitors - correct answer ✔✔Examples include Valproate, Isoniazid, Sulfonamides,
Amiodarone, Chloramphenicol, Ketoconazole, Grapefruit juice, Quinidine
Pharmacokinetics and pharmacodynamics - correct answer ✔✔Basis for prescribing decisions,
considering drug interactions and effects on target receptors
Beer's Criteria - correct answer ✔✔Tool identifying inappropriate medication use in older
adults, cautioning against certain drugs and interactions
Impacts of polypharmacy - correct answer ✔✔Include adverse drug events, increased
healthcare interactions, cognitive impairment, reduced adherence, falls, and mortality
CYP450 inhibitors function - correct answer ✔✔They decrease medication metabolism
CYP450 inhibitors consequences - correct answer ✔✔May cause toxicity if enzymes are inactive
or ineffectiveness if enzymes are overactive
Poor metabolism phenotype - correct answer ✔✔Occurs when CYP2D6 alleles have inactivating
mutations, leading to enzyme synthesis with impaired or no activity
