NR565 – Advanced Pharmacology Final Exam
Practice Test (100 Questions with Correct Answers)
2026/2027
1. Which factor most affects drug bioavailability?
A. Protein binding
B. First-pass metabolism
C. Renal clearance
D. Half-life
⬛ Answer: B
2. A drug with a narrow therapeutic index requires:
A. PRN dosing
B. Frequent monitoring
C. Short half-life
D. High lipid solubility
⬛ Answer: B
3. Which organ is primarily responsible for drug metabolism?
A. Kidneys
B. Lungs
C. Liver
D. Pancreas
⬛ Answer: C
4. What does a drug’s half-life determine?
A. Potency
B. Duration of action
C. Absorption rate
D. Protein binding
⬛ Answer: B
,5. Older adults are at higher risk of drug toxicity primarily due to:
A. Increased metabolism
B. Reduced renal clearance
C. Increased gastric acid
D. Increased lean body mass
⬛ Answer: B
6. Which route avoids first-pass metabolism?
A. Oral
B. Rectal
C. IV
D. Enteral
⬛ Answer: C
7. Cytochrome P450 enzymes are responsible for:
A. Drug excretion
B. Drug absorption
C. Drug metabolism
D. Drug transport
⬛ Answer: C
8. A drug that induces CYP450 enzymes will:
A. Increase drug levels
B. Decrease drug levels
C. Eliminate side effects
D. Increase protein binding
⬛ Answer: B
9. Which drug characteristic increases CNS penetration?
A. Water solubility
B. High molecular weight
C. Lipid solubility
, D. Ionization
⬛ Answer: C
10. What is pharmacodynamics?
A. What the body does to the drug
B. What the drug does to the body
C. Drug metabolism
D. Drug elimination
⬛ Answer: B
11. Therapeutic drug monitoring is essential for which medication?
A. Acetaminophen
B. Digoxin
C. Amoxicillin
D. Metformin
⬛ Answer: B
12. What does steady state mean?
A. Drug is eliminated
B. Drug is inactive
C. Rate of drug administration equals elimination
D. Drug has maximal effect
⬛ Answer: C
13. Which patient is at highest risk for adverse drug reactions?
A. Healthy young adult
B. Pediatric patient
C. Elderly patient with polypharmacy
D. Athletic adult
⬛ Answer: C
Practice Test (100 Questions with Correct Answers)
2026/2027
1. Which factor most affects drug bioavailability?
A. Protein binding
B. First-pass metabolism
C. Renal clearance
D. Half-life
⬛ Answer: B
2. A drug with a narrow therapeutic index requires:
A. PRN dosing
B. Frequent monitoring
C. Short half-life
D. High lipid solubility
⬛ Answer: B
3. Which organ is primarily responsible for drug metabolism?
A. Kidneys
B. Lungs
C. Liver
D. Pancreas
⬛ Answer: C
4. What does a drug’s half-life determine?
A. Potency
B. Duration of action
C. Absorption rate
D. Protein binding
⬛ Answer: B
,5. Older adults are at higher risk of drug toxicity primarily due to:
A. Increased metabolism
B. Reduced renal clearance
C. Increased gastric acid
D. Increased lean body mass
⬛ Answer: B
6. Which route avoids first-pass metabolism?
A. Oral
B. Rectal
C. IV
D. Enteral
⬛ Answer: C
7. Cytochrome P450 enzymes are responsible for:
A. Drug excretion
B. Drug absorption
C. Drug metabolism
D. Drug transport
⬛ Answer: C
8. A drug that induces CYP450 enzymes will:
A. Increase drug levels
B. Decrease drug levels
C. Eliminate side effects
D. Increase protein binding
⬛ Answer: B
9. Which drug characteristic increases CNS penetration?
A. Water solubility
B. High molecular weight
C. Lipid solubility
, D. Ionization
⬛ Answer: C
10. What is pharmacodynamics?
A. What the body does to the drug
B. What the drug does to the body
C. Drug metabolism
D. Drug elimination
⬛ Answer: B
11. Therapeutic drug monitoring is essential for which medication?
A. Acetaminophen
B. Digoxin
C. Amoxicillin
D. Metformin
⬛ Answer: B
12. What does steady state mean?
A. Drug is eliminated
B. Drug is inactive
C. Rate of drug administration equals elimination
D. Drug has maximal effect
⬛ Answer: C
13. Which patient is at highest risk for adverse drug reactions?
A. Healthy young adult
B. Pediatric patient
C. Elderly patient with polypharmacy
D. Athletic adult
⬛ Answer: C
