HNG 540 Exam 1 (2026) UPDATE Verified Questions And Answers | With
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What are the four concepts associated with pharmacokinetics? - (ANSWER)Absorptions
Metabolism
Distribution
Elimination
Pharmacokinetics - (ANSWER)what the body does to the drug
pharmacodynamics - (ANSWER)what the drug does to the body
protein binding - (ANSWER)the attachment of a drug molecule to a plasma or tissue protein, effectively
making the drug inactive but also keeping it within the body
Bioavailability - (ANSWER)A measure of the extent of drug absorption for a given drug and route (from
0% to 100%).
Advantage of minimal protein binding - (ANSWER)better tissue penetration as there is more free drug
available
disadvantage of minimal protein binding - (ANSWER)excreted much faster than a medication with a
higher binding level
What does protein binding effect? - (ANSWER)distribution, metabolism, and elimination
Disadvantage of strongly bound protein drugs - (ANSWER)will have lower concentration of free form
drugs available for interaction, leading to longer duration of action and low rates of elimination
True/False the unbound form of a drug cannot exert any effect - (ANSWER)False - the remaining
unbound portion of a drug is the ONLY portion that will exert any effect
, HNG 540 Exam 1 (2026) UPDATE Verified Questions And Answers | With
100% Correct Answers graded A+ Guaranteed Success!!
A drug displays 60% protein binding? What percentage will exert an effect? - (ANSWER)40% of the drug
is free/unbound, meaning that only that 40% will have an effect
What needs to be considered protein binding wise, when prescribing medications? - (ANSWER)-patients
serum protein levels
- dose of medication
Why must dosing be considered when prescribing medications in relation to protein binding? -
(ANSWER)this should be considered to ensure maximum drug amount is available to have an effect on
the body
What factor can influence gastric absorption when a drug is being administered orally? - (ANSWER)Lipid
solubility
What type of drugs tend to be absorbed more efficiently in the GI tract? - (ANSWER)lipophilic drugs
Why do lipophilic drugs get absorbed more efficiently in the GI tract and stomach? - (ANSWER)this is due
to cell membranes in the GI tract being composed of lipids, allows these drugs to cross more freely
first pass metabolism - (ANSWER)the substance degradation of an orally administered drug caused by
enzyme metabolism in the liver before the drug reaches the systemic circulation
True/False only PO medications undergo first pass metabolism - (ANSWER)False; all drugs regardless of
route of administrations must pass through the liver before reaching its target tissues and having
therapeutic effects; many drugs are not active until they reach the liver
What is the process of a PO drug going through first pass? - (ANSWER)drug administered -> drug
absorbed into the GI mucosa then to the blood stream-> portal circulation -> Liver metabolizes ->
biotransformations -> elimination
portal circulation - (ANSWER)a system of veins from GI tract to liver
100% Correct Answers graded A+ Guaranteed Success!!
What are the four concepts associated with pharmacokinetics? - (ANSWER)Absorptions
Metabolism
Distribution
Elimination
Pharmacokinetics - (ANSWER)what the body does to the drug
pharmacodynamics - (ANSWER)what the drug does to the body
protein binding - (ANSWER)the attachment of a drug molecule to a plasma or tissue protein, effectively
making the drug inactive but also keeping it within the body
Bioavailability - (ANSWER)A measure of the extent of drug absorption for a given drug and route (from
0% to 100%).
Advantage of minimal protein binding - (ANSWER)better tissue penetration as there is more free drug
available
disadvantage of minimal protein binding - (ANSWER)excreted much faster than a medication with a
higher binding level
What does protein binding effect? - (ANSWER)distribution, metabolism, and elimination
Disadvantage of strongly bound protein drugs - (ANSWER)will have lower concentration of free form
drugs available for interaction, leading to longer duration of action and low rates of elimination
True/False the unbound form of a drug cannot exert any effect - (ANSWER)False - the remaining
unbound portion of a drug is the ONLY portion that will exert any effect
, HNG 540 Exam 1 (2026) UPDATE Verified Questions And Answers | With
100% Correct Answers graded A+ Guaranteed Success!!
A drug displays 60% protein binding? What percentage will exert an effect? - (ANSWER)40% of the drug
is free/unbound, meaning that only that 40% will have an effect
What needs to be considered protein binding wise, when prescribing medications? - (ANSWER)-patients
serum protein levels
- dose of medication
Why must dosing be considered when prescribing medications in relation to protein binding? -
(ANSWER)this should be considered to ensure maximum drug amount is available to have an effect on
the body
What factor can influence gastric absorption when a drug is being administered orally? - (ANSWER)Lipid
solubility
What type of drugs tend to be absorbed more efficiently in the GI tract? - (ANSWER)lipophilic drugs
Why do lipophilic drugs get absorbed more efficiently in the GI tract and stomach? - (ANSWER)this is due
to cell membranes in the GI tract being composed of lipids, allows these drugs to cross more freely
first pass metabolism - (ANSWER)the substance degradation of an orally administered drug caused by
enzyme metabolism in the liver before the drug reaches the systemic circulation
True/False only PO medications undergo first pass metabolism - (ANSWER)False; all drugs regardless of
route of administrations must pass through the liver before reaching its target tissues and having
therapeutic effects; many drugs are not active until they reach the liver
What is the process of a PO drug going through first pass? - (ANSWER)drug administered -> drug
absorbed into the GI mucosa then to the blood stream-> portal circulation -> Liver metabolizes ->
biotransformations -> elimination
portal circulation - (ANSWER)a system of veins from GI tract to liver
