A patient with low serum C1q, C3 , and C4 Type III : Immune mediated glomerular injury with anti-
Granular pattern stain with antibody C3 & HTN would gen - antibody complexes
most likely have what ? Can be indicative of SLE.& nephritic
A patient with Chronic Hepatitis C& B , dark urine, HTN
, Azotemia, elevated serum creatinine and 1. Membranoproliferative glomerulonephritis
subendothelial immune complexes would have what ?
Can MPGN lead to RPGN Yes
mesangial cell hyper cellularity with subendothelial
What proliferates in MPGN ?
humps
What is typically destroyed in nephrotic syndromes? Podocytes
Do the same antibodies that create Rheumatic heart Fever No they are ditterent
create PSGN? PSGN quickly resolves
What two renal diseases have IgG &C3 depositions in
capillary basement membrane and Membranous nephropathy - nephrotic
Sub-epithelial humps which one is a nephritic vs. a APGN- nephritic
nephrotic syndrome?
Red cell casts
What can indicate Glomerular Bleeding ? Dysmorphic Casts
Acanthocyte
What kind of casts are seen in Nephrotic Syndrome? Fatty casts
What is the threshold for nephrotic or nephritic Syn- Nephrotic = 3.5 or greater
drome? Nephritic = less than 3.5
Protein loss , frothy urine , decrease in Antithrombin 3,
What happens in nephrotic syndrome:
decrease in immunoglobulins--- infection
What is the result of a decrease in AT 3 in nephrotic
There is thrombosis
Syndrome?
Will the plasma oncotic pressure in nephrotic Syndrome
Down
go up or down ?
1/7
, It upregulates it activity by making more proteins and
How does the liver respond to a loss of albumin? lipids... CREATES FATTY CASTS ( nephrotic syndrome) +
epithelial cellsm (oval fat bodies ) Maltese cross
Is the RAAS system upregulated or downregulated in It is upregulated due to volume contraction and a de-
Nephrotic Syndrome? crease in GFR --- this leads to EDEMA
Frothy Urine
Swelling of the ankles
Periorbital edema
What are the symptoms of Nephrotic Syndrome ?
High serum total cholesterol
Hypogammaglobinemia
Hypercoagulability
Dysmorphic RBC Casts
Decrease in filtration barrier
What symptoms /results can you see in Nephritic Syn-
Poor filtration here--- decrease GFR and increase in hy-
drome?
drostatic pressure--- Hypertension and Edema & High
BUN/ Creatinine
Dark Urine Swelling, ( BUN / Creatine), Oiguria, slight
What will Nephritic Syndrome present with? proteinuria Fatigue, azotemia, acanthocytes ( dysmorphic
RBCs
1. FSGS
2. Minimal Change Disease
What are the nephrotic syndromes 3. Membranous Nephropathy
4. Diabetic Glomerulonephropathy
5. Amyloidosis
1. Post strep Glomerulonephritis
2. Rapidly progressive glomerulonephriti
What are the nephritic Syndromes? 3. IgA nephropathy
4. Alport Syndrome
5. Membranoproliferative Glomerulonephritis
2/7
Granular pattern stain with antibody C3 & HTN would gen - antibody complexes
most likely have what ? Can be indicative of SLE.& nephritic
A patient with Chronic Hepatitis C& B , dark urine, HTN
, Azotemia, elevated serum creatinine and 1. Membranoproliferative glomerulonephritis
subendothelial immune complexes would have what ?
Can MPGN lead to RPGN Yes
mesangial cell hyper cellularity with subendothelial
What proliferates in MPGN ?
humps
What is typically destroyed in nephrotic syndromes? Podocytes
Do the same antibodies that create Rheumatic heart Fever No they are ditterent
create PSGN? PSGN quickly resolves
What two renal diseases have IgG &C3 depositions in
capillary basement membrane and Membranous nephropathy - nephrotic
Sub-epithelial humps which one is a nephritic vs. a APGN- nephritic
nephrotic syndrome?
Red cell casts
What can indicate Glomerular Bleeding ? Dysmorphic Casts
Acanthocyte
What kind of casts are seen in Nephrotic Syndrome? Fatty casts
What is the threshold for nephrotic or nephritic Syn- Nephrotic = 3.5 or greater
drome? Nephritic = less than 3.5
Protein loss , frothy urine , decrease in Antithrombin 3,
What happens in nephrotic syndrome:
decrease in immunoglobulins--- infection
What is the result of a decrease in AT 3 in nephrotic
There is thrombosis
Syndrome?
Will the plasma oncotic pressure in nephrotic Syndrome
Down
go up or down ?
1/7
, It upregulates it activity by making more proteins and
How does the liver respond to a loss of albumin? lipids... CREATES FATTY CASTS ( nephrotic syndrome) +
epithelial cellsm (oval fat bodies ) Maltese cross
Is the RAAS system upregulated or downregulated in It is upregulated due to volume contraction and a de-
Nephrotic Syndrome? crease in GFR --- this leads to EDEMA
Frothy Urine
Swelling of the ankles
Periorbital edema
What are the symptoms of Nephrotic Syndrome ?
High serum total cholesterol
Hypogammaglobinemia
Hypercoagulability
Dysmorphic RBC Casts
Decrease in filtration barrier
What symptoms /results can you see in Nephritic Syn-
Poor filtration here--- decrease GFR and increase in hy-
drome?
drostatic pressure--- Hypertension and Edema & High
BUN/ Creatinine
Dark Urine Swelling, ( BUN / Creatine), Oiguria, slight
What will Nephritic Syndrome present with? proteinuria Fatigue, azotemia, acanthocytes ( dysmorphic
RBCs
1. FSGS
2. Minimal Change Disease
What are the nephrotic syndromes 3. Membranous Nephropathy
4. Diabetic Glomerulonephropathy
5. Amyloidosis
1. Post strep Glomerulonephritis
2. Rapidly progressive glomerulonephriti
What are the nephritic Syndromes? 3. IgA nephropathy
4. Alport Syndrome
5. Membranoproliferative Glomerulonephritis
2/7
