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NURS 615 Exam 1 Study Guide 2026–2027 | Advanced Pharmacology Review & Practice Questions

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NURS 615 Exam 1 Study Guide 2026–2027: Comprehensive Advanced Pharmacology Review Covering Pharmacokinetics, Pharmacodynamics, Drug Classifications, Medication Safety, Drug Interactions, Adverse Effects, Prescribing Principles, Clinical Pharmacology Concepts, and High-Yield Practice Questions for NURS 615 Exam 1 Preparation.

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Nurs 615 Exam 1

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** Final Exam Questions With 100%
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,Nurse practitioner prescriptive authority is regulated by: 3. The State Board of Nursing for each state

1. The National Council of State Boards of Nursing
2. The U.S. Drug Enforcement Administration
3. The State Board of Nursing for each state
4. The State Board of Pharmacy


The benefits to the patient of having an Advanced 2. Nurses care for the patient from a holistic approach and include the patient in
Practice Registered Nurse (APRN) prescriber include: decision making regarding their care.

1. Nurses know more about Pharmacology than other
prescribers because they take it both in their basic
nursing program and in their APRN program.
2. Nurses care for the patient from a holistic approach
and include the patient in decision making regarding their
care.
3. APRNs are less likely to prescribe narcotics and other
controlled substances.
4. APRNs are able to prescribe independently in all
states, whereas a physician's assistant needs to have a
physician supervising their practice.


Clinical judgment in prescribing includes: 1. Factoring in the cost to the patient of the medication prescribed

1. Factoring in the cost to the patient of the medication
prescribed
2. Always prescribing the newest medication available for
the disease process
3. Handing out drug samples to poor patients
4. Prescribing all generic medications to cut costs


Criteria for choosing an effective drug for a disorder 2. Consulting nationally recognized guidelines for disease management
include:

1. Asking the patient what drug they think would work
best for them
2. Consulting nationally recognized guidelines for
disease management
3. Prescribing medications that are available as samples
before writing a prescription
4. Following U.S. Drug Enforcement Administration
guidelines for prescribing


Nurse practitioner practice may thrive under health-care 1. The demonstrated ability of nurse practitioners to control costs and improve
reform because of: patient outcomes

1. The demonstrated ability of nurse practitioners to
control costs and improve patient outcomes
2. The fact that nurse practitioners will be able to practice
independently
3. The fact that nurse practitioners will have full
reimbursement under health-care reform
4. The ability to shift accountability for Medicaid to the
state level


A patient's nutritional intake and laboratory results reflect 1. Distribution of drugs to target tissue may be affected.
hypoalbuminemia. This
is critical to prescribing because:

1. Distribution of drugs to target tissue may be affected.
2. The solubility of the drug will not match the site of
absorption.
3. There will be less free drug available to generate an
effect.
4. Drugs bound to albumin are readily excreted by the
kidneys.


Drugs that have a significant first-pass effect: 3. Are rapidly metabolized by the liver and may have little if any desired action

1. Must be given by the enteral (oral) route only
2. Bypass the hepatic circulation
3. Are rapidly metabolized by the liver and may have little
if any desired action
4. Are converted by the liver to more active and fat-
soluble forms

,The route of excretion of a volatile drug will likely be the: 2. Lungs

1. Kidneys
2. Lungs
3. Bile and feces
4. Skin


Medroxyprogesterone (Depo Provera) is prescribed 3. Increase the length of time a drug is available and active
intramuscularly (IM) to create a storage reservoir of the
drug. Storage reservoirs:

1. Assure that the drug will reach its intended target
tissue
2. Are the reason for giving loading doses
3. Increase the length of time a drug is available and
active
4. Are most common in collagen tissues


The NP chooses to give cephalexin every 8 hours based 2. Biological half-life
on knowledge of the drug's:

1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects


Azithromycin dosing requires that the first day's dosage 1. Rapidly achieves drug levels in the therapeutic range
be twice those of the other
4 days of the prescription. This is considered a loading
dose. A loading dose:

1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target
tissues


The point in time on the drug concentration curve that 3. Onset of action
indicates the first sign of a therapeutic effect is the:

1. Minimum adverse effect level
2. Peak of action
3. Onset of action
4. Therapeutic range


Phenytoin requires that a trough level be drawn. Peak 4. To determine if a drug is in the therapeutic range
and trough levels are done:

1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time
only
3. When there is a high correlation between the dose
and saturation of receptor sites
4. To determine if a drug is in the therapeutic range


A laboratory result indicates that the peak level for a drug 2. Concentration will produce an adverse response
is above the minimum toxic concentration. This means
that the:

1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long


Drugs that are receptor agonists may demonstrate what 3. Desensitization or downregulation with continuous use
property?

1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and
drug action

, Drugs that are receptor antagonists, such as beta 2. An exaggerated response if abruptly discontinued
blockers, may cause:

1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists


Factors that affect gastric drug absorption include: 3. Lipid solubility of the drug

1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow


Drugs administered via IV: 2. Begin distribution into the body immediately

1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed


When a medication is added to a regimen for a 2. Greater than the sum of the effects of each drug individually
synergistic effect, the combined effect of the drugs is:

1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug
individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual


Which of the following statements about bioavailability is 1. Bioavailability issues are especially important for drugs with narrow
true? therapeutic

1. Bioavailability issues are especially important for
drugs with narrow therapeutic ranges or sustained-
release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day
have greater bioavailability than drugs given once daily.
4. Combining an active drug with an inert substance
does not affect bioavailability.


Which of the following statements about the major 2. The blood-brain barrier slows the entry of many drugs into and from brain
distribution barriers (blood- cells.
brain or fetal-placental) is true?

1. Water soluble and ionized drugs cross these barriers
rapidly.
2. The blood-brain barrier slows the entry of many drugs
into and from brain cells.
3. The fetal-placental barrier protects the fetus from
drugs taken by the mother.
4. Lipid-soluble drugs do not pass these barriers and are
safe for pregnant women.


Drugs are metabolized mainly by the liver via phase I or 3. Change drug molecules to a form that an excretory organ can excrete
phase II reactions. The purpose of both of these types of
reactions is to:

1. Inactivate prodrugs before they can be activated by
target tissues
2. Change the drugs so they can cross plasma
membranes
3. Change drug molecules to a form that an excretory
organ can excrete
4. Make these drugs more ionized and polar to facilitate
excretion


Once they have been metabolized by the liver, the 4. All of the above
metabolites may be:

1. More active than the parent drug
2. Less active than the parent drug
3. Totally "deactivated" so they are excreted without any
effect
4. All of the above

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