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ALAT CHAPTER 2 - THE ANIMAL RESEARCH ENVIRONMENT QUESTIONS AND VERIFIED ANSWERS

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ALAT CHAPTER 2 - THE ANIMAL RESEARCH ENVIRONMENT QUESTIONS AND VERIFIED ANSWERS

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What does The Guide outline?


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- Primary source of guidelines and standards for lab animal care and use in
the US. Describes standards such as justification for species and number
used, availability of less-invasive alternatives, training of personnel,
occupational health and safety, Vet care, anesthesia and analgesia,
euthanasia, physical plant design, alleviation of pain and distress, disposal
of animals, and the safety of the working environment for personnel.
- The Guide identified the outcomes that need to be achieved but does not
specify how to achieve them




If an incident of animal misuse is not resolved after contacting your supervisor, you
can submit your concerns to whom?


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, IACUC Chair




Good Laboratory Practices Regulations (GLP'S)


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- Applies to non-clinical studies (safety data) in support of applications to
the FDA for food or drug research or marketing permits fir pesticides and
toxic products
- Requires staff training and SOPs and the establishment of a QA unit




Beyond food, water, shelter, and healthcare requirements, the AWA and AWR require
that dogs have the opportunity for ___ and nonhuman primates have ___ enrichment


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Physical exercise and phycological enrichment




What animals are covered under the Animal Welfare Act (AWA) and Animal Welfare
Regulations (AWR)


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Warm blooded animals, live or dead, EXCEPT: birds, rats, mice, and
agricultural animals used for food or fiber, horses

, According the the AWA, list the three types of members who must sit on the IACUC


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Chair, Veterinarian, Non-affiliated member




Good Laboratory Practices


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Regulations developed by the FDA and the EPA to validate and document
the process of safety testing




AWR's are published each year in the code of Federal Regulations. They outline...


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- Define roles of different individuals in the animal facility
- Provide more specific standards than the AWA itself
- Describes what facility must do in order to comply with AWA
- These are the MINIMUM acceptable standards in areas of housing,
feeding, watering, handling, sanitation, ventilation, transportation,
separation, and vet care.




US Government Principles for the Utilization and Care of Vertebrate Animals in
Testing, Research, and Training. (incorporated into PHS policy in 1986)


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