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Rationales 2026 Q&A | Instant Download
1. A 23-year-old man presents with right lower quadrant abdominal
pain, fever, and leukocytosis. Rebound tenderness is present at
McBurney’s point. What is the most likely diagnosis?
A. Gastroenteritis
B. Mesenteric adenitis
C. Acute appendicitis
D. Crohn disease
Acute localized RLQ pain with fever and rebound strongly suggests
appendicitis.
2. A 56-year-old woman with hypertension develops a dry cough
after starting medication. Which medication is responsible?
A. Amlodipine
B. Lisinopril
C. Hydrochlorothiazide
D. Losartan
ACE inhibitors cause bradykinin accumulation, leading to cough.
3. A 30-year-old man has sudden pleuritic chest pain and shortness
of breath. He is tall and thin. CXR shows unilateral hyperlucency
, with absent lung markings. Diagnosis?
A. PE
B. Pneumonia
C. Spontaneous pneumothorax
D. Aortic dissection
Tall, thin males are prone to primary spontaneous pneumothorax.
4. A 45-year-old woman with fatigue has low hemoglobin, low MCV,
and low ferritin. Most likely cause?
A. Thalassemia
B. Anemia of chronic disease
C. Iron deficiency anemia
D. Sideroblastic anemia
Low ferritin is diagnostic of iron deficiency.
5. A patient with COPD presents with hypoxia. Which OMT technique
helps improve rib motion?
A. Counterstrain
B. Rib raising
C. Facilitated positional release
D. Cranial manipulation
Rib raising enhances sympathetic tone and improves breathing
mechanics.
6. A 75-year-old man with Alzheimer disease has decreased levels of
which neurotransmitter?
A. Dopamine
B. Serotonin
C. GABA
, D. Acetylcholine
AD is associated with cholinergic neuron loss.
7. A 2-year-old child has barking cough and inspiratory stridor. Likely
diagnosis?
A. Epiglottitis
B. Bronchiolitis
C. Croup (laryngotracheobronchitis)
D. Asthma
Croup = parainfluenza, “steeple sign,” barking cough.
8. A 50-year-old man has crushing chest pain radiating to the left
arm. ECG shows ST elevation. What is first-line treatment?
A. Adenosine
B. Aspirin
C. Warfarin
D. Digoxin
Aspirin reduces mortality immediately in STEMI.
9. A 22-year-old man has urethritis and conjunctivitis after chlamydia
infection. Diagnosis?
A. Gout
B. Reactive arthritis
C. Rheumatoid arthritis
D. Osteoarthritis
Reactive arthritis is “can’t see, can’t pee, can’t climb a tree.”
10. A 65-year-old smoker has hematuria and flank pain. CT
shows a solid renal mass. Diagnosis?
A. Wilms tumor
B. Renal cyst