2026 Complete Actual Screenshots (Questions 1-
100) | NR507 Advanced Pathophysiology
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,SECTION 1: CELLULAR BIOLOGY & ADAPTATION (Questions
1–15)
Q1. A patient with chronic hypertension has an enlarged heart. This increase in muscle
mass is primarily due to:
, • A) Hyperplasia
• B) Metaplasia
• C) Hypertrophy
• D) Dysplasia
Correct Answer: C
Rationale: Cardiac muscle cells are terminally differentiated and adapt to increased
workload through hypertrophy (increase in cell size), not hyperplasia (increase in cell
number). Hypertrophy is an adaptive response to increased mechanical load.
Q2. Which of the following is a characteristic feature of apoptosis?
• A) Elicits a significant inflammatory response
• B) Results in cellular swelling and rupture
• C) Involves organized cell shrinkage and fragmentation
• D) Is always a pathological process
Correct Answer: C
Rationale: Apoptosis is programmed cell death characterized by organized cell
shrinkage, chromatin condensation, and fragmentation into apoptotic bodies. It does
NOT cause inflammation. Necrosis is characterized by cell swelling, rupture, and
inflammation.
Q3. A patient who smokes heavily develops squamous cell metaplasia in the bronchial
epithelium. This change is considered: