RN HESI Pharmacology V3 (2026) PDF |
Actual Exams with Rationales
A comprehensive test bank of 160 multiple-choice questions
covering nine body systems. Each question is paired with a
standard rationale explaining the correct answer, why key
distractors are wrong, and the nursing implication to remember.
F O R M AT
160 MCQs · 9 Body System Chapters · Answer Key with Rationales
AUDIENCE
Registered Nursing Students Preparing for HESI Pharmacology
, Table of Contents
Chapter 1 - Cardiovascular Pharmacology 2
Chapter 2 - Respiratory Pharmacology 6
Chapter 3 - Gastrointestinal Pharmacology 10
Chapter 4 - Endocrine Pharmacology 13
Chapter 5 - Neurological Pharmacology 18
Chapter 6 - Psychiatric Pharmacology 22
Chapter 7 - Renal and Urinary Pharmacology 26
Chapter 8 - Immune and Anti-Infective Pharmacology 29
Chapter 9 - Reproductive and Obstetric Pharmacology 33
Answer Key with Rationales 36
RN HESI Pharmacology V3 - 2026 Page 1
, Chapter 1 - Cardiovascular Pharmacology
1.A client is prescribed lisinopril for hypertension. Which finding should the
nurse report to the provider immediately?
A. Dry, persistent cough
B. Serum potassium of 6.1 mEq/L
C. Blood pressure of 128/78 mmHg
D. Mild headache
2.The nurse is teaching a client about metoprolol. Which statement by the client
indicates the teaching has been effective?
A. I will stop taking this medication if I feel tired.
B. I should check my heart rate before taking each dose.
C. I can take this medication with antacids for stomach upset.
D. I should expect my blood pressure to drop quickly within hours.
3.A client receiving IV heparin for a deep vein thrombosis has an aPTT of 110
seconds (control 35). Which action should the nurse take first?
A. Document the finding; the value is therapeutic
B. Discontinue the heparin infusion and notify the provider
C. Administer vitamin K intramuscularly
D. Increase the heparin infusion rate
4. Which laboratory value is most important for the nurse to monitor for a client
taking digoxin and furosemide?
A. Sodium
B. Potassium
C. Calcium
D. Magnesium
RN HESI Pharmacology V3 - 2026 Page 2
, 5. A client taking warfarin asks the nurse about dietary changes. Which
statement by the client indicates a need for further teaching?
A. I will eat the same amount of leafy green vegetables each week.
B. I should avoid drinking large amounts of alcohol.
C. I will increase my intake of broccoli and spinach to improve my blood.
D. I should not start any new herbal supplements without checking with my
provider.
The nurse is preparing to administer oral nitroglycerin extended-release capsules.
6.
Which instruction is appropriate?
A. Crush the capsule if the client cannot swallow it
B. Administer with a full glass of water and have the client sit upright
C. Give the medication sublingually for faster onset
D. Administer on an empty stomach to improve absorption
7.A client is started on amiodarone for atrial fibrillation. Which baseline test is
most important to obtain before therapy begins?
A. Liver function tests
B. Pulmonary function tests and chest x-ray
C. Renal function panel
D. Complete blood count
8.A client receiving IV streptokinase for an acute MI suddenly develops
angioedema and wheezing. Which medication should the nurse prepare to
administer?
A. Protamine sulfate
B. Epinephrine and diphenhydramine
C. Vitamin K
D. Flumazenil
9. Which assessment finding indicates a therapeutic response to clopidogrel in a
RN HESI Pharmacology V3 - 2026 Page 3
Actual Exams with Rationales
A comprehensive test bank of 160 multiple-choice questions
covering nine body systems. Each question is paired with a
standard rationale explaining the correct answer, why key
distractors are wrong, and the nursing implication to remember.
F O R M AT
160 MCQs · 9 Body System Chapters · Answer Key with Rationales
AUDIENCE
Registered Nursing Students Preparing for HESI Pharmacology
, Table of Contents
Chapter 1 - Cardiovascular Pharmacology 2
Chapter 2 - Respiratory Pharmacology 6
Chapter 3 - Gastrointestinal Pharmacology 10
Chapter 4 - Endocrine Pharmacology 13
Chapter 5 - Neurological Pharmacology 18
Chapter 6 - Psychiatric Pharmacology 22
Chapter 7 - Renal and Urinary Pharmacology 26
Chapter 8 - Immune and Anti-Infective Pharmacology 29
Chapter 9 - Reproductive and Obstetric Pharmacology 33
Answer Key with Rationales 36
RN HESI Pharmacology V3 - 2026 Page 1
, Chapter 1 - Cardiovascular Pharmacology
1.A client is prescribed lisinopril for hypertension. Which finding should the
nurse report to the provider immediately?
A. Dry, persistent cough
B. Serum potassium of 6.1 mEq/L
C. Blood pressure of 128/78 mmHg
D. Mild headache
2.The nurse is teaching a client about metoprolol. Which statement by the client
indicates the teaching has been effective?
A. I will stop taking this medication if I feel tired.
B. I should check my heart rate before taking each dose.
C. I can take this medication with antacids for stomach upset.
D. I should expect my blood pressure to drop quickly within hours.
3.A client receiving IV heparin for a deep vein thrombosis has an aPTT of 110
seconds (control 35). Which action should the nurse take first?
A. Document the finding; the value is therapeutic
B. Discontinue the heparin infusion and notify the provider
C. Administer vitamin K intramuscularly
D. Increase the heparin infusion rate
4. Which laboratory value is most important for the nurse to monitor for a client
taking digoxin and furosemide?
A. Sodium
B. Potassium
C. Calcium
D. Magnesium
RN HESI Pharmacology V3 - 2026 Page 2
, 5. A client taking warfarin asks the nurse about dietary changes. Which
statement by the client indicates a need for further teaching?
A. I will eat the same amount of leafy green vegetables each week.
B. I should avoid drinking large amounts of alcohol.
C. I will increase my intake of broccoli and spinach to improve my blood.
D. I should not start any new herbal supplements without checking with my
provider.
The nurse is preparing to administer oral nitroglycerin extended-release capsules.
6.
Which instruction is appropriate?
A. Crush the capsule if the client cannot swallow it
B. Administer with a full glass of water and have the client sit upright
C. Give the medication sublingually for faster onset
D. Administer on an empty stomach to improve absorption
7.A client is started on amiodarone for atrial fibrillation. Which baseline test is
most important to obtain before therapy begins?
A. Liver function tests
B. Pulmonary function tests and chest x-ray
C. Renal function panel
D. Complete blood count
8.A client receiving IV streptokinase for an acute MI suddenly develops
angioedema and wheezing. Which medication should the nurse prepare to
administer?
A. Protamine sulfate
B. Epinephrine and diphenhydramine
C. Vitamin K
D. Flumazenil
9. Which assessment finding indicates a therapeutic response to clopidogrel in a
RN HESI Pharmacology V3 - 2026 Page 3
