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Nursing Pharmacology: Cardiovascular Medications Exam - Latest 2026 Questions with Verified Answers & Rationales Graded A+

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This comprehensive exam review contains 98 actual NCLEX-style questions covering all major cardiovascular medications including anticoagulants such as heparin, warfarin sodium, and enoxaparin, thrombolytics including streptokinase and alteplase tPA, antiarrhythmics like digoxin, amiodarone, and procainamide, antihypertensives including ACE inhibitors, beta-blockers, and calcium channel blockers, diuretics such as furosemide, torsemide, spironolactone, and metolazone, and nitrates including nitroglycerin. Each question includes detailed rationales explaining correct answers and essential nursing interventions. This resource features priority nursing assessments, medication antidotes, therapeutic drug levels, common side effects, and critical patient teaching points. Perfect for nursing students preparing for HESI, ATI, NCLEX-RN, and pharmacology final examinations. The document includes questions on drug interactions, contraindications, laboratory monitoring including PT, INR, aPTT, and digoxin levels, plus emergency management of adverse drug reactions. All answers have been verified by experienced nursing educators and include comprehensive explanations to enhance understanding. This is the most current and complete cardiovascular pharmacology review available for nursing students.

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CARDIOVASCULAR TEST QUESTIONS

Question 1

WRONG

A nurse is providing instructions to a client who is receiving warfarin sodium
(Coumadin). Which statement made by the client indicates the need for further
instruction?

"I will observe the color of my urine and stool".


"I will take Ecotrin (Enteric coated aspirin) for my headaches".


"I will avoid drinking alcohol".


"I will take the medicine daily at the same time".

Question 1 Explanation:
Ecotrin is an aspirin-containing product and should be avoided due to the risk of
bleeding.

Question 2

WRONG

A nurse is caring for a client receiving a heparin intravenous (IV) infusion. The nurse
expects that which of the following laboratory will be prescribed to monitor the
therapeutic effect of heparin?

Prothrombin time (PT).


Activated partial thromboplastin time (Aptt).


Hematocrit (Hgb).


Hemoglobin (Hct).

Question 2 Explanation:
Activated partial thromboplastin time assess the therapeutic level of heparin.
Option A: Assess the therapeutic level of warfarin sodium (Coumadin). Options C
and D: Measures the aspect of the red blood cells.

, CARDIOVASCULAR TEST QUESTIONS



Question 3

WRONG

A client with atrial fibrillation is receiving a continuous heparin infusion at 1,000
units/hr. The nurse observes that the client is receiving the therapeutic effect based
on which of the following results?

Activated partial thromboplastin time of 30 seconds.


Activated partial thromboplastin time of 60 seconds.


Activated partial thromboplastin time of 120 seconds.


Activated partial thromboplastin time of 15 seconds.

Question 3 Explanation:
The normal range for activated partial thromboplastin time is 20-36 seconds. The
activated partial thromboplastin time must be 1.5 to 2.5 times the normal value, the
client's Appt would be considered therapeutic if it was 60 seconds.

Question 4

WRONG

A client is receiving intravenous heparin therapy. The nurse ensures the availability
in which of the following medication?

Acetylcysteine (Mucomyst).


Calcium gluconate.


Vitamin K (Mephyton).



Protamine sulfate.


Question 4 Explanation:
Protamine sulfate is the antidote that reverses the anticoagulant effects of heparin
by binding to it. Option A is the antidote for acetaminophen toxicity. Option B is the
antidote for magnesium sulfate toxicity. Option C is the antidote for warfarin
sodium toxicity.

, CARDIOVASCULAR TEST QUESTIONS




Question 5

CORRECT

A client is receiving a continuous infusion of streptokinase (Streptase). The client
suddenly complaints of a difficulty of breathing, itchiness, and nausea. Which of the
following should be the priority action of the nurse?

Stop the infusion and notify the physician.


Administer protamine sulfate and provide oxygen therapy.


Administer antihistamine then continue the infusion.


Slow the infusion and administer oxygen.

Question 5 Explanation:
Severe allergic reaction to streptokinase requires immediate discontinuation of
Streptokinase,then notify the physician and administer an adrenergic,
antihistamine, and/or corticosteroid agents as ordered.

Question 6

CORRECT

A client with deep vein thrombosis is receiving Streptokinase (Streptase). The nurse
would notify the physician if which of the following assessment is noted?

A temperature of 99.2° Fahrenheit.


A pulse rate of 99 beats per minute.


A respiratory rate of 25 breaths per minute.


A blood pressure of 185/110 mm Hg.

Question 6 Explanation:
Thrombolytic therapy is contraindicated with uncontrolled hypertension (systolic BP
>180 mm Hg and/or diastolic BP >110 mm Hg) because of the risk of cerebral
hemorrhage. Options A, B, and C may be present during the therapy but will not
warrant the immediate knowledge of the physician before starting the therapy.

, CARDIOVASCULAR TEST QUESTIONS




Question 7

CORRECT

A client who is receiving streptokinase therapy suddenly had a nose bleeding. The
nurse ensures the availability in which of the following medication?

Vitamin K (Mephyton).


Deferoxamine (Desferal).


Aminocaproic acid (Amicar).


Diphenhydramine (Benadryl).

Question 7 Explanation:
Bleeding can be reversed with the use of aminocaproic acid as an antidote for
streptokinase. Option A is the antidote for warfarin sodium toxicity. Option B is the
antidote for iron toxicity. Option D is an antihistamine that can be used for any
allergic reaction.

Question 8

WRONG

A nurse is providing health teachings regarding antiplatelet medications. Which of
the following is not true regarding the use of this medication?

Antiplatelet medication inhibits the aggregation of platelets in the clotting process,
thereby prolonging bleeding time.


Antiplatelet medications cannot be used with anticoagulants.


Take the medication with food to prevent gastrointestinal upset.


A routine bleeding time is monitored during the therapy.

Question 8 Explanation:
Antiplatelet and anticoagulant therapies are effective in keeping a clot from forming
or stopping the growth of one.

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