TIETZ CLINICAL CHEMISTRY FULL REVISION
NOTES WITH BIOCHEMISTRY AND
MOLECULAR DIAGNOSTIC PRINCIPLES
CONCEPTS
◉ Increased myoglobin.
Answer: MI (early indicator, nonspecific)
◉ Increased troponin.
Answer: MI (specific, striated muscle)
◉ Increased hCG.
Answer: pregnancy
◉ Extremely high hCG.
Answer: trophoblastic neoplasm
◉ Increased AFP.
Answer: open neural tube defects
◉ Decreased AFP.
,Answer: Down Syndrome and Trisomy 18
◉ L/S>2.
Answer: fetal mature lungs
◉ Increased amylase and lipase.
Answer: pancreatitis
◉ Increased urea.
Answer: renal or liver
◉ Increased uric acid.
Answer: renal
◉ Increased ammonia.
Answer: severe liver disease
◉ Increased urine creatinine.
Answer: muscular dystrophy
◉ Increased lpa.
Answer: heart disease
,◉ Increased BUN.
Answer: prerenal
◉ QC GOAL.
Answer: generation of reliable/accurate test results so the patient
receives proper medical care
◉ Quality assurance.
Answer: involves every step and every person
◉ Quality control.
Answer: the analytical phase of patient testing - the key to QC is
controls
◉ Controls.
Answer: to provide accuracy of patient results
◉ Precision.
Answer: agreement of results among themselves
◉ Accuracy.
, Answer: deviation from the true result, how close it is to the true
value
◉ Levey-Jennings chart.
Answer: QC recorded on
◉ Shift.
Answer: a change in which several consecutive control values fall on
one side of the mean commonly caused by an improperly made
reagent
◉ Trend.
Answer: gradual change in one direction (deteriorating reagent)
◉ Westgard rules.
Answer: Levey-Jennings chart interpreted by
◉ 13s.
Answer: (Rerun) a run is rejected when a single control values
exceeds the mean plus 3s or the mean minus 3s control limit
◉ 22s.
NOTES WITH BIOCHEMISTRY AND
MOLECULAR DIAGNOSTIC PRINCIPLES
CONCEPTS
◉ Increased myoglobin.
Answer: MI (early indicator, nonspecific)
◉ Increased troponin.
Answer: MI (specific, striated muscle)
◉ Increased hCG.
Answer: pregnancy
◉ Extremely high hCG.
Answer: trophoblastic neoplasm
◉ Increased AFP.
Answer: open neural tube defects
◉ Decreased AFP.
,Answer: Down Syndrome and Trisomy 18
◉ L/S>2.
Answer: fetal mature lungs
◉ Increased amylase and lipase.
Answer: pancreatitis
◉ Increased urea.
Answer: renal or liver
◉ Increased uric acid.
Answer: renal
◉ Increased ammonia.
Answer: severe liver disease
◉ Increased urine creatinine.
Answer: muscular dystrophy
◉ Increased lpa.
Answer: heart disease
,◉ Increased BUN.
Answer: prerenal
◉ QC GOAL.
Answer: generation of reliable/accurate test results so the patient
receives proper medical care
◉ Quality assurance.
Answer: involves every step and every person
◉ Quality control.
Answer: the analytical phase of patient testing - the key to QC is
controls
◉ Controls.
Answer: to provide accuracy of patient results
◉ Precision.
Answer: agreement of results among themselves
◉ Accuracy.
, Answer: deviation from the true result, how close it is to the true
value
◉ Levey-Jennings chart.
Answer: QC recorded on
◉ Shift.
Answer: a change in which several consecutive control values fall on
one side of the mean commonly caused by an improperly made
reagent
◉ Trend.
Answer: gradual change in one direction (deteriorating reagent)
◉ Westgard rules.
Answer: Levey-Jennings chart interpreted by
◉ 13s.
Answer: (Rerun) a run is rejected when a single control values
exceeds the mean plus 3s or the mean minus 3s control limit
◉ 22s.
