1|Page
NBME CBSE (USMLE Step 1) –EXAM (LATEST 2026) ||
MOST RECENT EXAM 2026|2027 ACTUAL COMPLETE
REAL VERIFIED EXAM QUESTIONS AND CORRECT
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+ | GUARANTEED SUCCESS!! NEWEST EXAM!!!
In rare cases, overproduction of uric acid can be genetic.
These disorders include hypoxanthine-guanine
phosphoribosyltransferase deficiency (Lesch-Nyhan
syndrome), glucose-6-phosphatase deficiency (von Gierke
disease), fructose 1-phosphate aldolase deficiency, and
PP-ribose-P synthetase variants.
It can also be linked to thyroid issues, renal insufficancy, or
chronic alcohol abuse.
A 27-year-old woman comes to the physician because of a
5-day history of a moderate vaginal discharge. Physical
examination shows a thin, white, vaginal discharge that
has a foul-smelling fishy odor. Vaginal pH is 6. A Pap
smear shows clumps of bacteria on the squamous cells.
There are no leukocytes. Culture of the discharge is most
likely to show an increased amount of which of the
following? - Answer-Gardnerella vaginalis
,2|Page
Gardnerella vaginalis causes vaginosis. (overgrowth of
bacteria in vagina)
Symptoms:
- white/gray vaginal discharge
- fishy smell
- non-painful
- Vaginal epithelial cells are covered with bacteria
Treatment: Metronidazole
A 20-year-old man comes to the physician because of a 1-
year history of progressive numbness of his arms. He
recently burned his right thumb while cooking, but he felt
no pain. Sensation to pain and temperature is decreased
throughout both upper extremities and across the
shoulders to the neck. Sensation is intact elsewhere. The
most likely cause of his condition is a lesion in which of the
following spinal cord structures? - Answer-Anterior white
commissure
,3|Page
Sounds like syringomyelia (central dilatation of cord with
resultant injury to gray horn and ant white commissure)
which mostly affects the cervical spinal cord.
Crossing fibers of spinothalamic tract are typically
damaged first. Bilateral loss of pain and temperature
sensation in upper extremities (fine touch sensation is
preserved)
A 40-year-old man comes to the physician for a routine
health maintenance examination. There is a strong family
history of myocardial infarctions occurring at the ages of
40 to 50 years. Physical examination shows no
abnormalities.
Serum studies show:
- Cholesterol, total:
increased
- HDL-cholesterol:
normal
- LDL-cholesterol:
increased
, 4|Page
- Triglycerides:
normal
Following treatment with lovastatin, his serum total
cholesterol and serum LDL-cholesterol concentrations
decrease. The beneficial effect of lovastatin most likely
occurs as a result of which of the following mechanisms? -
Answer-Increases LDL-receptors
Lovastatin is a HMG-CoA reductase inhibitor - these
decrease LDL (aka bad cholesterol) by inhibiting the
cholesterol precursor mevalonate and synthesizing LDL
receptors.
A 60-year-old man comes to the physician for a routine
health maintenance examination.
Physical examination shows no abnormalities. Urinalysis
shows:
- pH: 6.0
- Specific gravity: 1.018
NBME CBSE (USMLE Step 1) –EXAM (LATEST 2026) ||
MOST RECENT EXAM 2026|2027 ACTUAL COMPLETE
REAL VERIFIED EXAM QUESTIONS AND CORRECT
ANSWERS (VERIFIED ANSWERS) ALREADY GRADED
A+ | GUARANTEED SUCCESS!! NEWEST EXAM!!!
In rare cases, overproduction of uric acid can be genetic.
These disorders include hypoxanthine-guanine
phosphoribosyltransferase deficiency (Lesch-Nyhan
syndrome), glucose-6-phosphatase deficiency (von Gierke
disease), fructose 1-phosphate aldolase deficiency, and
PP-ribose-P synthetase variants.
It can also be linked to thyroid issues, renal insufficancy, or
chronic alcohol abuse.
A 27-year-old woman comes to the physician because of a
5-day history of a moderate vaginal discharge. Physical
examination shows a thin, white, vaginal discharge that
has a foul-smelling fishy odor. Vaginal pH is 6. A Pap
smear shows clumps of bacteria on the squamous cells.
There are no leukocytes. Culture of the discharge is most
likely to show an increased amount of which of the
following? - Answer-Gardnerella vaginalis
,2|Page
Gardnerella vaginalis causes vaginosis. (overgrowth of
bacteria in vagina)
Symptoms:
- white/gray vaginal discharge
- fishy smell
- non-painful
- Vaginal epithelial cells are covered with bacteria
Treatment: Metronidazole
A 20-year-old man comes to the physician because of a 1-
year history of progressive numbness of his arms. He
recently burned his right thumb while cooking, but he felt
no pain. Sensation to pain and temperature is decreased
throughout both upper extremities and across the
shoulders to the neck. Sensation is intact elsewhere. The
most likely cause of his condition is a lesion in which of the
following spinal cord structures? - Answer-Anterior white
commissure
,3|Page
Sounds like syringomyelia (central dilatation of cord with
resultant injury to gray horn and ant white commissure)
which mostly affects the cervical spinal cord.
Crossing fibers of spinothalamic tract are typically
damaged first. Bilateral loss of pain and temperature
sensation in upper extremities (fine touch sensation is
preserved)
A 40-year-old man comes to the physician for a routine
health maintenance examination. There is a strong family
history of myocardial infarctions occurring at the ages of
40 to 50 years. Physical examination shows no
abnormalities.
Serum studies show:
- Cholesterol, total:
increased
- HDL-cholesterol:
normal
- LDL-cholesterol:
increased
, 4|Page
- Triglycerides:
normal
Following treatment with lovastatin, his serum total
cholesterol and serum LDL-cholesterol concentrations
decrease. The beneficial effect of lovastatin most likely
occurs as a result of which of the following mechanisms? -
Answer-Increases LDL-receptors
Lovastatin is a HMG-CoA reductase inhibitor - these
decrease LDL (aka bad cholesterol) by inhibiting the
cholesterol precursor mevalonate and synthesizing LDL
receptors.
A 60-year-old man comes to the physician for a routine
health maintenance examination.
Physical examination shows no abnormalities. Urinalysis
shows:
- pH: 6.0
- Specific gravity: 1.018
