Florida NCLEX Exam Endocrine Disorders Updated Exam 2026
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1. A nurse is caring for a client newly diagnosed with type 1 diabetes mellitus. Which
hormone is deficient in this condition?
A. Glucagon
B. Cortisol
C. Insulin
D. Aldosterone
Answer: C. Insulin
Rationale: Type 1 diabetes mellitus results from autoimmune destruction of the pancreatic beta
cells, leading to an absolute deficiency of insulin. Without insulin, glucose cannot effectively
enter the body's cells, resulting in hyperglycemia and reliance on fat metabolism for energy.
2. Which assessment finding is most characteristic of hyperthyroidism?
A. Weight gain and cold intolerance
B. Bradycardia and constipation
C. Weight loss despite increased appetite
D. Dry skin and fatigue
Answer: C. Weight loss despite increased appetite
Rationale: Hyperthyroidism increases the body's metabolic rate, causing weight loss, heat
intolerance, tachycardia, nervousness, and increased appetite despite significant weight
reduction.
3. A client with diabetic ketoacidosis (DKA) is admitted to the emergency department.
Which laboratory value is expected?
A. Blood glucose of 70 mg/dL
B. Serum bicarbonate of 15 mEq/L
,C. Serum potassium of 2.5 mEq/L initially
D. Blood pH of 7.45
Answer: B. Serum bicarbonate of 15 mEq/L
Rationale: DKA is characterized by metabolic acidosis, resulting in decreased serum
bicarbonate and a low arterial pH. Hyperglycemia and ketone production contribute to this
acid-base imbalance.
4. Which clinical manifestation should the nurse expect in a client with hypothyroidism?
A. Tachycardia
B. Hyperactivity
C. Cold intolerance
D. Tremors
Answer: C. Cold intolerance
Rationale: Reduced thyroid hormone slows metabolism, causing cold intolerance, fatigue,
constipation, dry skin, weight gain, and slowed heart rate.
5. A nurse is teaching a client about insulin lispro. When should the client administer this
medication?
A. One hour before meals
B. At bedtime only
C. Within 15 minutes before eating
D. Two hours after meals
Answer: C. Within 15 minutes before eating
Rationale: Insulin lispro is a rapid-acting insulin with an onset of approximately 15 minutes. It
should be administered immediately before meals to reduce the risk of hypoglycemia.
6. Which electrolyte imbalance is commonly associated with untreated Addison disease?
A. Hypernatremia and hypokalemia
B. Hyponatremia and hyperkalemia
, C. Hypercalcemia and hypophosphatemia
D. Hypocalcemia and hypernatremia
Answer: B. Hyponatremia and hyperkalemia
Rationale: Addison disease causes decreased aldosterone production, leading to sodium loss,
potassium retention, dehydration, and hypotension.
7. A client reports excessive thirst, frequent urination, and blurred vision. Which disorder is
most likely?
A. Diabetes insipidus
B. Hypothyroidism
C. Diabetes mellitus
D. Cushing syndrome
Answer: C. Diabetes mellitus
Rationale: Polyuria, polydipsia, polyphagia, and blurred vision are classic manifestations of
uncontrolled diabetes mellitus due to persistent hyperglycemia.
8. Which assessment finding is most indicative of Cushing syndrome?
A. Weight loss
B. Bronze skin pigmentation
C. Moon face and buffalo hump
D. Muscle rigidity
Answer: C. Moon face and buffalo hump
Rationale: Excess cortisol causes characteristic fat redistribution resulting in a rounded face,
dorsocervical fat pad (buffalo hump), truncal obesity, and thin extremities.
WITH Recent Newest Verified And Well Analyzed Exam Questions
(Actual Exam 2026-2027) Correct Detailed &
Verified ANSWERS (100% Accurate Solutions) ALREADY
GRADED A+||NEWEST VERSION Of The Exam Guarantee Pass!!
1. A nurse is caring for a client newly diagnosed with type 1 diabetes mellitus. Which
hormone is deficient in this condition?
A. Glucagon
B. Cortisol
C. Insulin
D. Aldosterone
Answer: C. Insulin
Rationale: Type 1 diabetes mellitus results from autoimmune destruction of the pancreatic beta
cells, leading to an absolute deficiency of insulin. Without insulin, glucose cannot effectively
enter the body's cells, resulting in hyperglycemia and reliance on fat metabolism for energy.
2. Which assessment finding is most characteristic of hyperthyroidism?
A. Weight gain and cold intolerance
B. Bradycardia and constipation
C. Weight loss despite increased appetite
D. Dry skin and fatigue
Answer: C. Weight loss despite increased appetite
Rationale: Hyperthyroidism increases the body's metabolic rate, causing weight loss, heat
intolerance, tachycardia, nervousness, and increased appetite despite significant weight
reduction.
3. A client with diabetic ketoacidosis (DKA) is admitted to the emergency department.
Which laboratory value is expected?
A. Blood glucose of 70 mg/dL
B. Serum bicarbonate of 15 mEq/L
,C. Serum potassium of 2.5 mEq/L initially
D. Blood pH of 7.45
Answer: B. Serum bicarbonate of 15 mEq/L
Rationale: DKA is characterized by metabolic acidosis, resulting in decreased serum
bicarbonate and a low arterial pH. Hyperglycemia and ketone production contribute to this
acid-base imbalance.
4. Which clinical manifestation should the nurse expect in a client with hypothyroidism?
A. Tachycardia
B. Hyperactivity
C. Cold intolerance
D. Tremors
Answer: C. Cold intolerance
Rationale: Reduced thyroid hormone slows metabolism, causing cold intolerance, fatigue,
constipation, dry skin, weight gain, and slowed heart rate.
5. A nurse is teaching a client about insulin lispro. When should the client administer this
medication?
A. One hour before meals
B. At bedtime only
C. Within 15 minutes before eating
D. Two hours after meals
Answer: C. Within 15 minutes before eating
Rationale: Insulin lispro is a rapid-acting insulin with an onset of approximately 15 minutes. It
should be administered immediately before meals to reduce the risk of hypoglycemia.
6. Which electrolyte imbalance is commonly associated with untreated Addison disease?
A. Hypernatremia and hypokalemia
B. Hyponatremia and hyperkalemia
, C. Hypercalcemia and hypophosphatemia
D. Hypocalcemia and hypernatremia
Answer: B. Hyponatremia and hyperkalemia
Rationale: Addison disease causes decreased aldosterone production, leading to sodium loss,
potassium retention, dehydration, and hypotension.
7. A client reports excessive thirst, frequent urination, and blurred vision. Which disorder is
most likely?
A. Diabetes insipidus
B. Hypothyroidism
C. Diabetes mellitus
D. Cushing syndrome
Answer: C. Diabetes mellitus
Rationale: Polyuria, polydipsia, polyphagia, and blurred vision are classic manifestations of
uncontrolled diabetes mellitus due to persistent hyperglycemia.
8. Which assessment finding is most indicative of Cushing syndrome?
A. Weight loss
B. Bronze skin pigmentation
C. Moon face and buffalo hump
D. Muscle rigidity
Answer: C. Moon face and buffalo hump
Rationale: Excess cortisol causes characteristic fat redistribution resulting in a rounded face,
dorsocervical fat pad (buffalo hump), truncal obesity, and thin extremities.
