Exam Prep for
HEMATOLOGY - [ELSEVIER]
** Expert-Verified Explanation
** Questions with Verified Answer
** New Edition | 2026-2027 Updated
** 100% Guaranteed Pass
** 100% Correct Answers | Graded A+
,A physician wants to obtain a Serum ferritin
measure of a patient's iron stores.
Which of the following tests would Serum ferritin concentrations reflect the body's
be the most suitable? storage of ferritin. Serum iron measures free iron,
a. Serum iron and serum transferrin provides a measure of how
b. Serum transferrin (TIBC) many binding sites are available to bind iron and is
c. Serum ferritin used with transferrin saturation, the percentage of
d. Transferrin saturation sites available to carry iron.
2. A 68-year-old woman visited her Iron-deficiency anemia
physician with reports of fatigue and
weakness. A CBC was ordered, and Iron-deficiency anemia resulting from the
the patient's results were as follows: decreased mean corpuscular volume (MCV) and
RBC 2.50 × 1012/ L Hct 18.8% MCH mean corpuscular hemoglobin (MCH), indicating
24.8 pg Hgb 6.2 g/ dL MCV 75.2 fL hypochromic microcytic cells. Vitamin B12 defi-
MCHC 33% Which of the following ciency typically exhibits macrocytosis. Anemia of
would be a plausible diagnosis for chronic inflammation tends to exhibit a mild
this patient? anemia, with a hemoglobin value of approxi-
a. Iron-deficiency anemia mately 9 to 11 g/dL. Hemochromatosis is not an
b. Vitamin B12 deficiency anemia and, untreated, exhibits a normal to ele-
c. Anemia of chronic inflammation vated red blood cell count.
d. Hemochromatosis
3. A peripheral smear shows a Sideroblastic anemia
decreased RBC count with
microcytic, hypochromic cells with The inclusions suggest the presence of excess
small grapelike inclusions in the storage iron. Sideroblastic anemia is a disorder
RBCs on both Wright stain and characterized by elevated iron stores resulting
Prussian blue stain. This is from an inability to incorporate iron into heme. The
consistent with: inclusions suggest the presence of excess storage
a. Iron-deficiency anemia iron. Ringed sideroblasts may also be found in
b. Sideroblastic anemia bone marrow examinations. Iron- deficiency
c. Pernicious anemia anemia shows a microcytic hypochro- mic anemia;
d. β-Thalassemia minor however, it is characterized by a lack of iron.
Pernicious anemia is a megaloblastic ane- mia.
Thalassemia minor shows a microcytic hypo-
chromic anemia; however, it often has an elevated
red blood cell count with hypochromic, micro- cytic
cells but would not normally show iron inclusions
(although transfusion-dependent thal- assemias
may exhibit transfusion-associated iron excess.
4. Given the following results of iron Iron-deficiency anemia
studies, which disorder is the most
likely? ↓ Serum iron ↑ TIBC ↓ Ferritin Iron-deficiency anemia is most likely, because
↓ % Saturation sideroblastic anemia and hemochromatosis show
a. Iron-deficiency anemia increased iron and ferritin with a decreased total
b. Sideroblastic anemia iron-binding capacity (TIBC) whereas anemia of
c. Anemia of chronic inflammation chronic inflammation has decreased serum iron
d. Hemochromatosis and percent saturation but normal-to-increased
serum ferritin.
, 5. Acquired sideroblastic anemia Malabsorption
may be present in all of the following
except: Gastrointestinal disease may lead to malabsorp-
a. Alcoholism tion, which could possibly affect iron absorption.
b. Lead poisoning Alcoholism and lead poisoning can lead to a sec-
c. Malabsorption ondary sideroblastic anemia, and primary sidero-
d. Myelodysplastic syndromes blastic anemia may be seen in myelodysplastic
syndromes, such as refractory anemia with ringed
sideroblasts (RARS).
6. A patient has a macrocytic Intrinsic factor antibodies
anemia, and the physician suspects
pernicious anemia. Which test would Intrinsic factor antibodies would be present in
best rule in a definitive diagnosis of patients with a true megaloblastic anemia,
pernicious anemia? because it is characterized by the destruction of
a. Homocysteine parietal cells, which produce the intrinsic factor
b. Intrinsic factor antibodies needed for B12 absorption. Homocysteine is
c. Ova and parasite examination for elevated in both vitamin B12 and folic acid
D. latum deficiencies. Diphyllobothrium latum can cause
d. Bone marrow examination megaloblastic anemia because it competes for
vitamin B12 in the intestines; however, testing for
ova and parasites alone will not define the
diagnosis. A bone marrow examination could
determine that megaloblastic features were
present; however, it would not be specific for
pernicious anemia.
7. Megaloblastic anemias result from Deficiencies in Vitamin B12 and folic acid
which of the following?
a. Deficiencies in free erythrocyte Megaloblastic anemias result from deficiencies in
protoporphyrin vitamin B12 and folic acid. Both are needed for
b. Deficiencies in Vitamin B12 and normal cell maturation. Iron and hepcidin play a
folic acid role in anemias with iron problems, whereas
c. Increases in iron and hepcidin decreased free erythrocyte protoporphyrin (FEP)
d. Decreases in liver function is seen in some porphyrias. Decreased liver func-
tion, alcoholism, and severe hypothyroidism can
cause macrocytic anemia, but the anemia is not
megaloblastic.
8. A patient's bone marrow showed Pernicious anemia
erythroid hyperplasia with signs of
dysplastic maturation, particularly in Pernicious anemia is a megaloblastic anemia that
the RBC precursors. This is results from defective DNA synthesis from lack of
consistent with which of the vitamin B12, often showing dysplastic changes in
following? the cells and sometimes requiring a bone marrow
a. Sickle cell anemia examination to confirm the deficiency, particu- larly
b. β-Thalassemia major to differentiate from myelodysplastic syn- dromes.
c. Pernicious anemia The others do not have a need for bone marrow
d. G6PD deficiency examination.
HEMATOLOGY - [ELSEVIER]
** Expert-Verified Explanation
** Questions with Verified Answer
** New Edition | 2026-2027 Updated
** 100% Guaranteed Pass
** 100% Correct Answers | Graded A+
,A physician wants to obtain a Serum ferritin
measure of a patient's iron stores.
Which of the following tests would Serum ferritin concentrations reflect the body's
be the most suitable? storage of ferritin. Serum iron measures free iron,
a. Serum iron and serum transferrin provides a measure of how
b. Serum transferrin (TIBC) many binding sites are available to bind iron and is
c. Serum ferritin used with transferrin saturation, the percentage of
d. Transferrin saturation sites available to carry iron.
2. A 68-year-old woman visited her Iron-deficiency anemia
physician with reports of fatigue and
weakness. A CBC was ordered, and Iron-deficiency anemia resulting from the
the patient's results were as follows: decreased mean corpuscular volume (MCV) and
RBC 2.50 × 1012/ L Hct 18.8% MCH mean corpuscular hemoglobin (MCH), indicating
24.8 pg Hgb 6.2 g/ dL MCV 75.2 fL hypochromic microcytic cells. Vitamin B12 defi-
MCHC 33% Which of the following ciency typically exhibits macrocytosis. Anemia of
would be a plausible diagnosis for chronic inflammation tends to exhibit a mild
this patient? anemia, with a hemoglobin value of approxi-
a. Iron-deficiency anemia mately 9 to 11 g/dL. Hemochromatosis is not an
b. Vitamin B12 deficiency anemia and, untreated, exhibits a normal to ele-
c. Anemia of chronic inflammation vated red blood cell count.
d. Hemochromatosis
3. A peripheral smear shows a Sideroblastic anemia
decreased RBC count with
microcytic, hypochromic cells with The inclusions suggest the presence of excess
small grapelike inclusions in the storage iron. Sideroblastic anemia is a disorder
RBCs on both Wright stain and characterized by elevated iron stores resulting
Prussian blue stain. This is from an inability to incorporate iron into heme. The
consistent with: inclusions suggest the presence of excess storage
a. Iron-deficiency anemia iron. Ringed sideroblasts may also be found in
b. Sideroblastic anemia bone marrow examinations. Iron- deficiency
c. Pernicious anemia anemia shows a microcytic hypochro- mic anemia;
d. β-Thalassemia minor however, it is characterized by a lack of iron.
Pernicious anemia is a megaloblastic ane- mia.
Thalassemia minor shows a microcytic hypo-
chromic anemia; however, it often has an elevated
red blood cell count with hypochromic, micro- cytic
cells but would not normally show iron inclusions
(although transfusion-dependent thal- assemias
may exhibit transfusion-associated iron excess.
4. Given the following results of iron Iron-deficiency anemia
studies, which disorder is the most
likely? ↓ Serum iron ↑ TIBC ↓ Ferritin Iron-deficiency anemia is most likely, because
↓ % Saturation sideroblastic anemia and hemochromatosis show
a. Iron-deficiency anemia increased iron and ferritin with a decreased total
b. Sideroblastic anemia iron-binding capacity (TIBC) whereas anemia of
c. Anemia of chronic inflammation chronic inflammation has decreased serum iron
d. Hemochromatosis and percent saturation but normal-to-increased
serum ferritin.
, 5. Acquired sideroblastic anemia Malabsorption
may be present in all of the following
except: Gastrointestinal disease may lead to malabsorp-
a. Alcoholism tion, which could possibly affect iron absorption.
b. Lead poisoning Alcoholism and lead poisoning can lead to a sec-
c. Malabsorption ondary sideroblastic anemia, and primary sidero-
d. Myelodysplastic syndromes blastic anemia may be seen in myelodysplastic
syndromes, such as refractory anemia with ringed
sideroblasts (RARS).
6. A patient has a macrocytic Intrinsic factor antibodies
anemia, and the physician suspects
pernicious anemia. Which test would Intrinsic factor antibodies would be present in
best rule in a definitive diagnosis of patients with a true megaloblastic anemia,
pernicious anemia? because it is characterized by the destruction of
a. Homocysteine parietal cells, which produce the intrinsic factor
b. Intrinsic factor antibodies needed for B12 absorption. Homocysteine is
c. Ova and parasite examination for elevated in both vitamin B12 and folic acid
D. latum deficiencies. Diphyllobothrium latum can cause
d. Bone marrow examination megaloblastic anemia because it competes for
vitamin B12 in the intestines; however, testing for
ova and parasites alone will not define the
diagnosis. A bone marrow examination could
determine that megaloblastic features were
present; however, it would not be specific for
pernicious anemia.
7. Megaloblastic anemias result from Deficiencies in Vitamin B12 and folic acid
which of the following?
a. Deficiencies in free erythrocyte Megaloblastic anemias result from deficiencies in
protoporphyrin vitamin B12 and folic acid. Both are needed for
b. Deficiencies in Vitamin B12 and normal cell maturation. Iron and hepcidin play a
folic acid role in anemias with iron problems, whereas
c. Increases in iron and hepcidin decreased free erythrocyte protoporphyrin (FEP)
d. Decreases in liver function is seen in some porphyrias. Decreased liver func-
tion, alcoholism, and severe hypothyroidism can
cause macrocytic anemia, but the anemia is not
megaloblastic.
8. A patient's bone marrow showed Pernicious anemia
erythroid hyperplasia with signs of
dysplastic maturation, particularly in Pernicious anemia is a megaloblastic anemia that
the RBC precursors. This is results from defective DNA synthesis from lack of
consistent with which of the vitamin B12, often showing dysplastic changes in
following? the cells and sometimes requiring a bone marrow
a. Sickle cell anemia examination to confirm the deficiency, particu- larly
b. β-Thalassemia major to differentiate from myelodysplastic syn- dromes.
c. Pernicious anemia The others do not have a need for bone marrow
d. G6PD deficiency examination.
