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NURS 635 Midterm Questions and Answers Updated 2026

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NURS 635 Midterm Questions and Answers Updated 2026

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NURS635 - NURS635

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NURS635 - NURS635

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NURS 635 Midterm
Questions and Answers
Updated 2026
PharmacologyB-
BAnswerBtheBstudyBofBdrugsBandBtheirBstructure,BtargetsBofBaction,BmechanismsBofBact
ionB(MOA),BdistributionB(howBtheBbodyBdisbursesBthemBthroughoutBtheBbody),Bdesired
BphysiologicBeffectsB(efficacy)BandBundesirableBsideBeffectsB(toxicity).

PharmacokineticsB-BAnswerB(absorption,Bdistribution,BmetabolismBandBelimination

AbsorptionB-
BAnswerBabsorptionBfromBtheBadministrationBsiteBeitherBdirectlyBorBindirectlyBintoBtheB
blood/plasma.

DistributionB-
BAnswerBreversibly/irreversiblyBmovementBofBdrugBfromBtheBbloodstreamBintoBtheBinter
stitialBandBintracellularBfluid.

MetabolismB-
BAnswerBdrugBbiotransformationBviaBmetabolicBpathways,BprimarilyBtheBliver,BorBbyBoth
erBtissues.

EliminationB-
BAnswerBhowBparentBdrugB&BitsBmetabolitesBareBeliminatedBfromBtheBbody

FactorsBaffectingBabsorptionB-BAnswerB·BGastrointestinalBpHBchanges

·BGastricBemptying

·BGastric/intestinalBenzymes

·BBileBacidsB&BbiliaryBfunction

, ·BGastrointestinalBfloraB(typeBandBquantityBofBbacteria)

·BFoodB&BnutrientBinteractionsB(mostBcommonBinteractionBinfluencingBGIBdrugBabsorpti
on)

·BLipidBsolubilityBofBtheBdrug

FactorsBaffectingBdistributionB-
BAnswerB·BMembraneBpermeability:BCrossBmembranesBtoBsiteBofBaction

·BBloodBbrainBbarrierBreducesBtheBspeedBofBdrugBpassageBintoBandBoutBofBbrainBtissu
e

·BPlasmaBproteinBbinding:BdrugsBboundBtoBplasmaBproteinsBdoBnotBcrossBmembranesB(
Note:BMalnutritionB=BâalbuminB=BáBfreeBdrugB=BgreaterBpharmacologicBresponse)

·BAgingBcauseBaBreductionBinBproductionBofBplasmaBproteins

·BLipophilicityBofBdrug:BlipophilicBdrugsBconcentrateBinBadiposeBtissue;BremainBinBtheBb
odyBforBaBlongerBperiodBofBtime

FactorsBaffectingBmetabolismB-
BAnswerBoBDrugsBcanBundergoBmetabolismBinBtheBlungs,Bblood,Bliver,BintestinesBandBki
dney

oBVolatileBdrugsBareBprimarilyBexcretedBbyBtheBlungs

·BTheBbodyBchangesBdrugsBtoBmoreBorBlessBactiveBformsB(metabolites),BincreasesBwate
rBsolubilityBtoBincreaseBelimination.

FactorsBaffectingBexcretionB-
BAnswerBEliminationBofBdrugsBmostBoftenBinvolvesBrenalBfunctionB(renalBbloodBflow,Bcr
eatinineBclearanceB[CrCl]).

·BLinearB=BRateBofBeliminationBisBproportionalBtoBamountBofBdrugBpresent.

·BDosageBincreasesBresultBinBproportionalBincreaseBinBplasmaBdrugBlevels.

·BUnbindingBofBnonvolatileBdrugsBfromBplasmaBproteinBbindingBsites

·BVolatileBdrugsBareBexcretedBbyBtheBlungs

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Type: Exam (elaborations)
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NURS 635 Midterm Questions and Answers Updated 2026

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