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Summary Digestive System and Metabolism: Anatomy, Enzymes, and Nutrient Absorption

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Understand how food becomes fuel! This complete guide covers the alimentary canal (mouth to anus), digestive enzymes, bile, absorption, and metabolic pathways (glycolysis, citric acid cycle, oxidative phosphorylation). Also includes carbohydrate, protein, and fat metabolism. Ideal for nutrition, medical, and health science students.

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BUNDLE 8: DIGESTIVE SYSTEM, METABOLISM, ENDOCRINE &
INTEGUMENTARY SYSTEMS
__________________________________________________


PART A: DIGESTIVE SYSTEM
__________________________________________________

INTRODUCTION
The digestive system = alimentary canal + accessory organs + digestive processes
preparing food for absorption.

GI tract: 23-26 feet long; from mouth to esophagus, stomach, small intestines, rectum, to
anus.

Accessory organs: teeth and gums, tongue, salivary glands, liver, gall bladder, pancreas.

__________________________________________________

ANATOMIC AND PHYSIOLOGIC OVERVIEW
Mouth: Contains tongue and teeth (chewing, swallowing); salivary glands (digestion).

Esophagus:

• In mediastinum; anterior to spine, posterior to trachea and heart
• ~25 cm long
• Passes through diaphragm at diaphragmatic hiatus

Stomach:

• Left upper abdomen; under left lobe of liver and diaphragm
• Overlying most of pancreas
• Four regions: cardia, fundus, body, pylorus

Small intestine:

• Longest segment; 2/3 total length
• Three sections: duodenum, jejunum, ileum

Large intestine:

• Ascending (right), transverse (right to left), descending (left)
• Terminal: sigmoid colon, rectum, anus

__________________________________________________

,DEFINITIONS IN ALIMENTARY TRACT
Ingestion: Taking food into alimentary tract (eating, drinking).

Propulsion: Mixes and moves contents along tract.

Digestion:

• Mechanical breakdown (e.g., mastication/chewing)
• Chemical digestion into small molecules by enzymes

Absorption: Digested substances pass through walls into blood/lymph capillaries.

Elimination: Undigested/unabsorbed substances excreted as feces by defecation.

__________________________________________________

ORGANS OF THE DIGESTIVE SYSTEM

Alimentary Canal (GI Tract)
Long tube from mouth to anus:

• Mouth
• Pharynx
• Esophagus
• Stomach
• Small intestine
• Large intestine
• Rectum and anal canal

Accessory Organs
Secretions pass through ducts into tract:

• Three pairs of salivary glands
• Pancreas
• Liver and biliary tract

__________________________________________________

BASIC STRUCTURE OF ALIMENTARY CANAL
Four layers (from esophagus onwards):

1. Adventitia or outer covering
2. Muscle layer
3. Submucosal layer
4. Mucosa lining

, Adventitia or Serosa
Outermost layer.

• Thorax: loose fibrous tissue
• Abdomen: serous membrane (peritoneum)

Peritoneum
Largest serous membrane; closed sac with small amount of serous fluid.

• Richly supplied with blood/lymph vessels; many lymph nodes
• Physical barrier to local infection spread
• Can isolate infective focus (e.g., appendicitis)

Two layers:

• Parietal peritoneum: Lines abdominal wall
• Visceral peritoneum: Covers organs within abdominal and pelvic cavities

__________________________________________________

MOUTH (ORAL CAVITY)
Bounded by:

• Anteriorly: Lips
• Posteriorly: Continuous with oropharynx
• Laterally: Muscles of cheeks
• Superiorly: Bony hard palate and muscular soft palate
• Inferiorly: Muscular tongue and soft tissues of floor

Tongue
Functions:

• Chewing (mastication)
• Swallowing (deglutition)
• Speech
• Taste

Nerve endings of taste in papillae; widely distributed in epithelium of tongue, soft palate,
pharynx, epiglottis.

Teeth
Embedded in alveoli/sockets of alveolar ridges of mandible and maxilla.

• Two sets: temporary (deciduous) and permanent
• At birth, both present in immature form in mandible and maxilla

Functions by shape:

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