TEST BANK
Genetics and Genomics in Nursing and Health Care
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
2nd Edition
www.Plusbay.Plus
,Table of Contents
Chapter 01 DNA Structure and Function 1
Chapter 02 Protein Synthesis 9
Chapter 03 Genetic Influence on Cell Division, Differentiation, and Gametogenesis 19
Chapter 04 Patterns of Inheritance 29
Chapter 05 Epigenetic Influences on Gene Expression 43
Chapter 06 Autosomal Inheritance and Disorders 47
Chapter 07 Sex Chromosome and Mitochondrial Inheritance and Disorders 55
Chapter 08 Family History and Pedigree Construction 61
Chapter 09 Congenital Anomalies, Basic Dysmorphology, and Genetic Assessment 68
Chapter 10 Enzyme and Collagen Disorders 74
Chapter 11 Common Childhood-Onset Genetic Disorders 84
Chapter 12 Common Adult-Onset Disorders 95
Chapter 13 Cardiovascular Disorders 103
Chapter 14 The Genetics of Cancer 110
Chapter 15 Genetic Contributions to Psychiatric and Behavioral Disorders 119
Chapter 16 Genetic and Genomic Testing 124
Chapter 17 Assessing Genomic Variation in Drug Response 129
Chapter 18 Health Professionals and Genomic Care 135
Chapter 19 Financial, Ethical, Legal, and Social Considerations 140
Chapter 20 Genetic and Genomic Variation 144
www.Plusbay.Plus
, Test Bank - Genetics and Genomics in Nursing and Health Care, 2nd Edition (Beery, 2019)
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
Chapter 1: DNA Structure and Function
sd sd sd sd sd
MULTIPLE CHOICE sd
1. In which body or cell area are most genes in humans located?
sd sd sd sd sd sd sd sd sd sd sd
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasma membrane sd
ANS: A s d s d
Most genes are part of the DNA located in the nucleus of body cells. Only a few genes are located i
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
n a cell’s mitochondrion or mitochondria. There are no genes or DNA in either the cytoplasm or the
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
plasma membranes of any cell.
sd sd sd sd sd
2. Which condition or statement exemplifies the concept of genomics rather than genetics?
sd sd sd sd sd sd sd sd sd sd sd
a. The gene for insulin is located on chromosome 11 in all people.
sd sd sd sd sd sd sd sd sd sd sd
b. Expression of any single gene is dependent on inheriting two alleles. sd sd sd sd sd sd sd sd sd sd
c. Sex-linked recessive disorders affect males more often than females. sd sd sd sd sd sd sd sd
d. One allele for each gene is inherited from the mother, and one is inherited from the fath
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
er.
ANS: A s d s d
Genetics is the study of the general mechanisms of heredity and the variation of inherited traits.
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
Genomics is the study of the function of all the nucleotide sequences present within the entire gen
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ome of a s p e c i e s , Wi nWcW
l u.d iTn B
sd gSgeMn.
esWiS
sd n DNA coding regions and DNA noncoding
sd ds sd sd sd sd sd sd
regions. Selections B, C, and D all refer to mechanisms of heredity. Only selection A refers
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
to the function of a specific nucleotide sequence.
sd sd sd sd sd sd sd
3. What is the purpose of phosphorous in a DNA strand?
sd sd sd sd sd sd sd sd sd
a. Linking the nucleotides into a strand sd sd sd sd sd
b. Holding complementary strands together sd sd sd
c. Ensuring that a purine is always paired with a pyrimidine sd sd sd sd sd sd sd sd sd
d. Preventing the separation of double-stranded DNA into single-stranded DNA sd sd sd sd sd sd sd sd
ANS: A s d s d
Each nucleoside becomes a complete nucleotide when a phosphate group is attached. The phos
sd sd sd sd sd sd sd sd sd sd sd sd sd
phates have multiple binding sites, and each one can link to two nucleotides. These linkages all
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ow the nucleotides to be connected when placed into the DNA strand. The nucleotides within e
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ach strand are held in position by the linked phosphate groups, which act like the string holding
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
a strand of beads together, forming a necklace.
sd sd sd sd sd sd sd
4. What is the term used to define alternative forms of a gene that may result in different expr
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ession of the trait coded for by that gene? sd sd sd sd sd sd sd sd
a. Alleles
b. Bases
c. Centromeres
d. Diploids s
ANS: A
d s d
www.Plusbay.Plus 1|Page sd sd sd sd sd
, Test Bank - Genetics and Genomics in Nursing and Health Care, 2nd Edition (Beery, 2019)
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
For each single gene, two alternative forms of that gene, known as alleles, together control how
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
that gene is expressed. The alleles may be identical in their sequence but do not have to be. When
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd s
a dominant allele is paired with a recessive allele, only the dominant allele is expressed, and the
d sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
recessive allele is silent. When a dominant allele is paired with another dominant allele, they ar
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
e both expressed (usually equally). Recessive alleles are only expressed when they are homozy
sd sd sd sd sd sd sd sd sd sd sd sd sd
gous. Bases are the essential part of a nucleotide, of which there are many within any gene regio
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
n. Centromeres are the pinched-
sd sd sd sd
in part of a chromosome between the p arms and the q arms. The term diploid refers to the norm
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
al number of chromosome pairs within a cell. It is an adjective, not a noun. Therefore, the plural
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
diploids does not exist. sd sd sd
5. What percentage of bases in a stretch of double-stranded DNA that contains 30% guanine
sd sd sd sd sd sd sd sd sd sd sd sd sd
(G) bases would be adenine (A)?
sd sd sd sd sd
a. 70%
b. 60%
c. 30%
d. 20%
ANS: D s d s d
Because of complementary pairing, if 30% of the bases are guanine (G), which always pairs with c
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ytosine C, these two bases account for 60% of the total bases in this stretch. The remaining bases
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
make up 40% of the total. This 40% is composed of equal percentages of thymine (T) and adenine
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
(A).
6. What is the term used to describe the organized picture of the paired chromosomes within a cell
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
used to determine whether chromosome numbers, structures, and banding patterns are
sd sd sd sd sd sd sd sd sd sd
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS: C s d s d
A karyotype is a picture of an organized arrangement of all of the chromosomes within one cell
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
during the metaphase section of mitosis. The chromosomes are paired and then arranged by num
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ber according to size and centromere position. The banding pattern of each pair is analyzed to de
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
termine whether areas have been deleted, expanded, or translocated. A pedigree also is a picture
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
, but it illustrates several generations of a family history.
sd sd sd sd sd sd sd sd sd
Phenotypes are observable traits. Autotype is not a genetic term. sd sd sd sd sd sd sd sd sd
7. What would be the sequence of DNA that is complementary to a DNA section with the base sequ
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ence of GGTCAATCCTTAG? sd sd
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC s
dANS: D s d
www.Plusbay.Plus 2|Pagesd sd sd sd sd
Genetics and Genomics in Nursing and Health Care
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
2nd Edition
www.Plusbay.Plus
,Table of Contents
Chapter 01 DNA Structure and Function 1
Chapter 02 Protein Synthesis 9
Chapter 03 Genetic Influence on Cell Division, Differentiation, and Gametogenesis 19
Chapter 04 Patterns of Inheritance 29
Chapter 05 Epigenetic Influences on Gene Expression 43
Chapter 06 Autosomal Inheritance and Disorders 47
Chapter 07 Sex Chromosome and Mitochondrial Inheritance and Disorders 55
Chapter 08 Family History and Pedigree Construction 61
Chapter 09 Congenital Anomalies, Basic Dysmorphology, and Genetic Assessment 68
Chapter 10 Enzyme and Collagen Disorders 74
Chapter 11 Common Childhood-Onset Genetic Disorders 84
Chapter 12 Common Adult-Onset Disorders 95
Chapter 13 Cardiovascular Disorders 103
Chapter 14 The Genetics of Cancer 110
Chapter 15 Genetic Contributions to Psychiatric and Behavioral Disorders 119
Chapter 16 Genetic and Genomic Testing 124
Chapter 17 Assessing Genomic Variation in Drug Response 129
Chapter 18 Health Professionals and Genomic Care 135
Chapter 19 Financial, Ethical, Legal, and Social Considerations 140
Chapter 20 Genetic and Genomic Variation 144
www.Plusbay.Plus
, Test Bank - Genetics and Genomics in Nursing and Health Care, 2nd Edition (Beery, 2019)
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
Chapter 1: DNA Structure and Function
sd sd sd sd sd
MULTIPLE CHOICE sd
1. In which body or cell area are most genes in humans located?
sd sd sd sd sd sd sd sd sd sd sd
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasma membrane sd
ANS: A s d s d
Most genes are part of the DNA located in the nucleus of body cells. Only a few genes are located i
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
n a cell’s mitochondrion or mitochondria. There are no genes or DNA in either the cytoplasm or the
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
plasma membranes of any cell.
sd sd sd sd sd
2. Which condition or statement exemplifies the concept of genomics rather than genetics?
sd sd sd sd sd sd sd sd sd sd sd
a. The gene for insulin is located on chromosome 11 in all people.
sd sd sd sd sd sd sd sd sd sd sd
b. Expression of any single gene is dependent on inheriting two alleles. sd sd sd sd sd sd sd sd sd sd
c. Sex-linked recessive disorders affect males more often than females. sd sd sd sd sd sd sd sd
d. One allele for each gene is inherited from the mother, and one is inherited from the fath
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
er.
ANS: A s d s d
Genetics is the study of the general mechanisms of heredity and the variation of inherited traits.
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
Genomics is the study of the function of all the nucleotide sequences present within the entire gen
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ome of a s p e c i e s , Wi nWcW
l u.d iTn B
sd gSgeMn.
esWiS
sd n DNA coding regions and DNA noncoding
sd ds sd sd sd sd sd sd
regions. Selections B, C, and D all refer to mechanisms of heredity. Only selection A refers
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
to the function of a specific nucleotide sequence.
sd sd sd sd sd sd sd
3. What is the purpose of phosphorous in a DNA strand?
sd sd sd sd sd sd sd sd sd
a. Linking the nucleotides into a strand sd sd sd sd sd
b. Holding complementary strands together sd sd sd
c. Ensuring that a purine is always paired with a pyrimidine sd sd sd sd sd sd sd sd sd
d. Preventing the separation of double-stranded DNA into single-stranded DNA sd sd sd sd sd sd sd sd
ANS: A s d s d
Each nucleoside becomes a complete nucleotide when a phosphate group is attached. The phos
sd sd sd sd sd sd sd sd sd sd sd sd sd
phates have multiple binding sites, and each one can link to two nucleotides. These linkages all
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ow the nucleotides to be connected when placed into the DNA strand. The nucleotides within e
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ach strand are held in position by the linked phosphate groups, which act like the string holding
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
a strand of beads together, forming a necklace.
sd sd sd sd sd sd sd
4. What is the term used to define alternative forms of a gene that may result in different expr
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ession of the trait coded for by that gene? sd sd sd sd sd sd sd sd
a. Alleles
b. Bases
c. Centromeres
d. Diploids s
ANS: A
d s d
www.Plusbay.Plus 1|Page sd sd sd sd sd
, Test Bank - Genetics and Genomics in Nursing and Health Care, 2nd Edition (Beery, 2019)
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
For each single gene, two alternative forms of that gene, known as alleles, together control how
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
that gene is expressed. The alleles may be identical in their sequence but do not have to be. When
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd s
a dominant allele is paired with a recessive allele, only the dominant allele is expressed, and the
d sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
recessive allele is silent. When a dominant allele is paired with another dominant allele, they ar
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
e both expressed (usually equally). Recessive alleles are only expressed when they are homozy
sd sd sd sd sd sd sd sd sd sd sd sd sd
gous. Bases are the essential part of a nucleotide, of which there are many within any gene regio
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
n. Centromeres are the pinched-
sd sd sd sd
in part of a chromosome between the p arms and the q arms. The term diploid refers to the norm
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
al number of chromosome pairs within a cell. It is an adjective, not a noun. Therefore, the plural
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
diploids does not exist. sd sd sd
5. What percentage of bases in a stretch of double-stranded DNA that contains 30% guanine
sd sd sd sd sd sd sd sd sd sd sd sd sd
(G) bases would be adenine (A)?
sd sd sd sd sd
a. 70%
b. 60%
c. 30%
d. 20%
ANS: D s d s d
Because of complementary pairing, if 30% of the bases are guanine (G), which always pairs with c
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ytosine C, these two bases account for 60% of the total bases in this stretch. The remaining bases
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
make up 40% of the total. This 40% is composed of equal percentages of thymine (T) and adenine
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
(A).
6. What is the term used to describe the organized picture of the paired chromosomes within a cell
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
used to determine whether chromosome numbers, structures, and banding patterns are
sd sd sd sd sd sd sd sd sd sd
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS: C s d s d
A karyotype is a picture of an organized arrangement of all of the chromosomes within one cell
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
during the metaphase section of mitosis. The chromosomes are paired and then arranged by num
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ber according to size and centromere position. The banding pattern of each pair is analyzed to de
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
termine whether areas have been deleted, expanded, or translocated. A pedigree also is a picture
sd sd sd sd sd sd sd sd sd sd sd sd sd sd
, but it illustrates several generations of a family history.
sd sd sd sd sd sd sd sd sd
Phenotypes are observable traits. Autotype is not a genetic term. sd sd sd sd sd sd sd sd sd
7. What would be the sequence of DNA that is complementary to a DNA section with the base sequ
sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd sd
ence of GGTCAATCCTTAG? sd sd
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC s
dANS: D s d
www.Plusbay.Plus 2|Pagesd sd sd sd sd
