Week 3 Exam: NR566 / NR 566
(Latest ) Advanced
Pharmacology for Care of the Family
| Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
5-α-Reductase Inhibitors (finasteride): Indications
Answer:
· Used to reduce prostate size, will take several months. Relieve symptoms
of bladder outlet obstruction.
For large prostate
,Question:
5-α-Reductase Inhibitors: MOA
Answer:
· Acts in reproductive tissue to inhibit 5-alpha-reductase, and enzyme that
converts testosterone to dihydrotestosterone (DHT) which is the active
form of testosterone in the prostate.
· Treatment reduces levels of DHT in blood by 70% (but does not reduce
testosterone levels).
· By decreasing DHT, it promotes regression of epithelial tissue thereby
decreases mechanical obstruction of urethra.
Question:
5-α-Reductase Inhibitors: Adverse Effects
Answer:
· Increased likelihood of high-grade tumor.
· Can decrease ejaculate volume and libido.
· Teratogenic to XY fetus and should not be taken by pregnant patients.
Pregnant women should not handle the pill, crush or break them.
· Do not donate blood if on this medication. Stop for at least 1 month.
, Question:
5-α-Reductase Inhibitors: Key prescribing consideration
Answer:
finasteride
· Do not prescribe if suspecting prostate cancer. If symptoms do not
improve and PSA does not lower, evaluate for prostate cancer.
Question:
α1-Adrenergic Antagonists (silodosin, tamsulosin): MOA
Answer:
· Blockade of a1 receptors relaxes smooth muscle in bladder neck (trigone
and sphincter), prostate capsule, and prostatic urethra, thereby decreasing
dynamic obstruction of urethra. Symptomatic improvement of urinary flow
develops rapidly.
· Used for mild prostatic enlargement. TO be taken lifelong.
(Latest ) Advanced
Pharmacology for Care of the Family
| Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
5-α-Reductase Inhibitors (finasteride): Indications
Answer:
· Used to reduce prostate size, will take several months. Relieve symptoms
of bladder outlet obstruction.
For large prostate
,Question:
5-α-Reductase Inhibitors: MOA
Answer:
· Acts in reproductive tissue to inhibit 5-alpha-reductase, and enzyme that
converts testosterone to dihydrotestosterone (DHT) which is the active
form of testosterone in the prostate.
· Treatment reduces levels of DHT in blood by 70% (but does not reduce
testosterone levels).
· By decreasing DHT, it promotes regression of epithelial tissue thereby
decreases mechanical obstruction of urethra.
Question:
5-α-Reductase Inhibitors: Adverse Effects
Answer:
· Increased likelihood of high-grade tumor.
· Can decrease ejaculate volume and libido.
· Teratogenic to XY fetus and should not be taken by pregnant patients.
Pregnant women should not handle the pill, crush or break them.
· Do not donate blood if on this medication. Stop for at least 1 month.
, Question:
5-α-Reductase Inhibitors: Key prescribing consideration
Answer:
finasteride
· Do not prescribe if suspecting prostate cancer. If symptoms do not
improve and PSA does not lower, evaluate for prostate cancer.
Question:
α1-Adrenergic Antagonists (silodosin, tamsulosin): MOA
Answer:
· Blockade of a1 receptors relaxes smooth muscle in bladder neck (trigone
and sphincter), prostate capsule, and prostatic urethra, thereby decreasing
dynamic obstruction of urethra. Symptomatic improvement of urinary flow
develops rapidly.
· Used for mild prostatic enlargement. TO be taken lifelong.
