Week 2 Exam: NR566 / NR 566
(Latest ) Advanced
Pharmacology for Care of the Family
| Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
Tetracyclines MOA
Answer:
· Suppress bacterial growth by inhibiting protein synthesis. Bacteriostatic
· Bind to 30S ribosomal subunit and inhibit binding of transfer RNA to
messenger RNA-ribosome complex.
· As a result, amino acids cannot Grow peptide chain.
· Enters bacterial cell through energy-dependent transport system to
achieve function
,Question:
Tetracyclines Patient Education
Answer:
· Do not administer with calcium supplements, milk, iron supplements,
magnesium-containing laxatives and most antacids because it decreases
absorption
o To minimize interference, administer 1 hour before or 2 hours after
ingestion of these agents.
· Causes increased sensitivity of skin to ultraviolet light causing
exaggerated sunburn. Avoid sun exposure, wear protective clothing, apply
sunscreen.
· Take with food to prevent GI irritation. Food may decrease absorption,
however.
Avoid giving to children under age of 8
Patients should notify provider of any diarrhea as this can indicate a
superinfection that can be life threatening.
Question:
Tetracyclines Effects in Pregnancy
Answer:
· When taken during pregnancy after fourth month gestation, it will stain
deciduous teeth of infant. Does not affect permanent teeth.
· Contraindicated
, Question:
Macrolides (erythromycin) Adverse Effects
Answer:
· Considered one of the safest antibiotics
· GI effects: epigastric pain, nausea, vomiting, diarrhea
· QT prolongation and sudden cardiac death when combined with a
CYP3A4 inhibitor
o CCB (verapamil, diltiazem), azole antifungal drugs (ketoconazole), HIV PI
(ritonavir), nefazodone (antidepressant)
Question:
Clindamycin (macrolide) MOA
Answer:
· Binds to 50S subunit of bacterial ribosomes and thereby inhibits protein
synthesis (bacteriostatic)
Question:
Clindamycin Therapeutic Indication
Answer:
· Effective against gram-positive cocci (widely used as alternative to
penicillin)
· For severe streptococcal infection and gas gangrene
· For anaerobic infections outside of CNS
(Latest ) Advanced
Pharmacology for Care of the Family
| Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
Tetracyclines MOA
Answer:
· Suppress bacterial growth by inhibiting protein synthesis. Bacteriostatic
· Bind to 30S ribosomal subunit and inhibit binding of transfer RNA to
messenger RNA-ribosome complex.
· As a result, amino acids cannot Grow peptide chain.
· Enters bacterial cell through energy-dependent transport system to
achieve function
,Question:
Tetracyclines Patient Education
Answer:
· Do not administer with calcium supplements, milk, iron supplements,
magnesium-containing laxatives and most antacids because it decreases
absorption
o To minimize interference, administer 1 hour before or 2 hours after
ingestion of these agents.
· Causes increased sensitivity of skin to ultraviolet light causing
exaggerated sunburn. Avoid sun exposure, wear protective clothing, apply
sunscreen.
· Take with food to prevent GI irritation. Food may decrease absorption,
however.
Avoid giving to children under age of 8
Patients should notify provider of any diarrhea as this can indicate a
superinfection that can be life threatening.
Question:
Tetracyclines Effects in Pregnancy
Answer:
· When taken during pregnancy after fourth month gestation, it will stain
deciduous teeth of infant. Does not affect permanent teeth.
· Contraindicated
, Question:
Macrolides (erythromycin) Adverse Effects
Answer:
· Considered one of the safest antibiotics
· GI effects: epigastric pain, nausea, vomiting, diarrhea
· QT prolongation and sudden cardiac death when combined with a
CYP3A4 inhibitor
o CCB (verapamil, diltiazem), azole antifungal drugs (ketoconazole), HIV PI
(ritonavir), nefazodone (antidepressant)
Question:
Clindamycin (macrolide) MOA
Answer:
· Binds to 50S subunit of bacterial ribosomes and thereby inhibits protein
synthesis (bacteriostatic)
Question:
Clindamycin Therapeutic Indication
Answer:
· Effective against gram-positive cocci (widely used as alternative to
penicillin)
· For severe streptococcal infection and gas gangrene
· For anaerobic infections outside of CNS
