Week 5 Exam: NR565 / NR 565
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Sulfonylurea: Contraindications
Answer:
· Only for T2D
· Can cause hypoglycemia that can last for days requiring dextrose
infusion. More likely to occur in patients with kidney or liver dysfunction.
Question:
Sulfonylurea: Pregnancy
Answer:
· Contraindicated during pregnancy and breastfeeding due to risk of
neonatal hypoglycemia and potential teratogenic effects observed In
animal studies.
,Question:
Sulfonylurea: Side Effect
Answer:
· Hypoglycemia
· Weight gain
· Cardiovascular toxicity: Only for first-generation
Question:
Thiazolidinediones (TZDs): Adverse Effects
Answer:
· Contraindicated for severe HF and patients with history of bladder cancer.
Heart failure due to fluid retention
hypoglycemia
ovulation
bladder cancer (with prolonged high doses. Sx: blood in urine, painful and
frequent urination)
fractures (take supplemental vitamin D)
liver failure.
, Question:
Hypothyroidism treatment in Infants
Answer:
· Hypothyroidism in infants is called congenital hypothyroidism
· May be permanent or transient.
· Can cause developmental delay and derangement of growth
· In absence of thyroid hormones, child develops a large and protruding
tongue, potbelly, ad dwarfism stature.
· Development of nervous system, bones, teeth and muscles is impaired.
· Treatment includes:
o Thyroid hormone replacement.
o If treated immediately, development will be normal
o If delayed by 3-4 weeks, some permanent disability will be evident.
o Replacement therapy should continue for 3 years, then stopped for 4
weeks to determine if permanent or transient.
(Latest ) Advanced
Pharmacology Fundamentals |
Questions & Answers | 100%
Correct | Grade A - Chamberlain
Question:
Sulfonylurea: Contraindications
Answer:
· Only for T2D
· Can cause hypoglycemia that can last for days requiring dextrose
infusion. More likely to occur in patients with kidney or liver dysfunction.
Question:
Sulfonylurea: Pregnancy
Answer:
· Contraindicated during pregnancy and breastfeeding due to risk of
neonatal hypoglycemia and potential teratogenic effects observed In
animal studies.
,Question:
Sulfonylurea: Side Effect
Answer:
· Hypoglycemia
· Weight gain
· Cardiovascular toxicity: Only for first-generation
Question:
Thiazolidinediones (TZDs): Adverse Effects
Answer:
· Contraindicated for severe HF and patients with history of bladder cancer.
Heart failure due to fluid retention
hypoglycemia
ovulation
bladder cancer (with prolonged high doses. Sx: blood in urine, painful and
frequent urination)
fractures (take supplemental vitamin D)
liver failure.
, Question:
Hypothyroidism treatment in Infants
Answer:
· Hypothyroidism in infants is called congenital hypothyroidism
· May be permanent or transient.
· Can cause developmental delay and derangement of growth
· In absence of thyroid hormones, child develops a large and protruding
tongue, potbelly, ad dwarfism stature.
· Development of nervous system, bones, teeth and muscles is impaired.
· Treatment includes:
o Thyroid hormone replacement.
o If treated immediately, development will be normal
o If delayed by 3-4 weeks, some permanent disability will be evident.
o Replacement therapy should continue for 3 years, then stopped for 4
weeks to determine if permanent or transient.
