ASCP Certification Exam Questions with Correct Answers 2026 | Complete Practice Exam & Study Guide

ASCP CERTIFICATION QUESTIONS WITH
CORRECT ANSWERS 2026
loss of DNA --> nuclear pallor = - CORRECT ANSWER -karyolysis



nuclear shrinkage and increased basophilia = - CORRECT ANSWER -pyknosis



fragmented, pyknotic nucleus = - CORRECT ANSWER -karyorrhexis



architecture is preserved in whatsnecrosis? - CORRECT ANSWER -coagulative



bacteria/fungus/inflammation/enzymes are part of whatsnecrosis? -sCORRECT ANSWERs-liquifactive



WBC recruitment steps - CORRECT ANSWERs-margination/rolling --> adhesion --> transmigration --
> migration



WBC rolling via - CORRECT ANSWER -selectins



WBC adhesion via - CORRECT ANSWER -integrins



Virchow's triad of thrombosis - CORRECT ANSWER -
endothelial injury + stasis/turbulent blood flow + hypercoagulability



mostsabundant collagen - CORRECT ANSWER -type I



collagen in scar tissue, tendons, ligaments - CORRECT ANSWER -type I



collagen in cartilage - CORRECT ANSWER -type II



reticular collagen type -sCORRECT ANSWERs-type III

,BM collagen type - CORRECT ANSWER -type IV



what does vWF do? -sCORRECT ANSWER -helps platelets adhere to endothelium



FBN1 mutation = what disorder - CORRECT ANSWER -Marfan syndrome



fibrillin mutation = what disorder - CORRECT ANSWER -Marfan syndrome



mutated collagen = what disorder - CORRECT ANSWER -Ehlers-Danlos



musty urine odor = what disorder - CORRECT ANSWER -PKU



mutated beta-hexosaminidase A = what disorder - CORRECT ANSWER -Tay Sachs



increased gangliosides = what disorder - CORRECT ANSWER -Tay Sachs



mutated sphingomyelinase/increased sphingomyelin = what disorder - CORRECT ANSWER -Neimann Pick



mutated glucocerebrosidase/increased glucocerebroside = what disorder - CORRECT ANSWER -Gaucher



trisomy 13 aka -sCORRECT ANSWER -Patau



Patau = - CORRECT ANSWER -trisomy 13



trisomy 18 aka -sCORRECT ANSWER -Edwards'



Edwards' = - CORRECT ANSWER -trisomy 18

,3 viable trisomies - CORRECT ANSWER -13, 18, 21



maternal imprintings- CORRECT ANSWER -silencing of maternal allele



paternal imprintings- CORRECT ANSWER -silencing of paternal allele



#1 infant tumor - CORRECT ANSWER -hemangioma



#1 extracranial child tumor - CORRECT ANSWER -neuroblastoma



PDK1 mutation = what disorder - CORRECT ANSWER -adultsPKD



polycystin-1 defect = whatsdisorder - CORRECT ANSWER -adult PKD



PKHD1 mutation = what disorder - CORRECT ANSWER -childhood PKD



fibrocystin defect = what disorder - CORRECT ANSWER -childhood PKD



MHS2/MLH1 mutation = whatsdisorder - CORRECT ANSWER -HNPCC/Lynch



mostscommon newborn viral infection - CORRECT ANSWER -CMV



Hyaline membrane disease - CORRECT ANSWER -defective surfactant --> solid, airless lungs in infant



Beckwith-Wiedemann - CORRECT ANSWER -macrosomia/large tongue/large kidneys

kidney, pancreas, adrenal issues

earlobe creases



type I HSs- CORRECT ANSWER -immediate, allergy

, type II HS -sCORRECT ANSWER -Ab-mediated



HS type of myasthenia gravis - CORRECT ANSWER -II



HS type of Grave's - CORRECT ANSWER -II



HS type of pernicious/hemolytic anemia - CORRECT ANSWER -II



HS type of Goodpasture's - CORRECT ANSWER -II



type III HS - CORRECT ANSWER -immune complex (Ag-Ab) mediated



HS type of serum sickness - CORRECT ANSWER -III



HS type of arthus rxn - CORRECT ANSWER -III



arthus rxn - CORRECT ANSWER -localized tissue necrosis from acute immune complex vasculitis



type IV HS - CORRECT ANSWER -delayed via Tcells



wire loopsglomerulonephritis = - CORRECT ANSWER -lupus



hyperacute rejection - CORRECT ANSWER -min-hours (previous instance)



acute rejection - CORRECT ANSWER -days-weeks



chronic rejection - CORRECT ANSWER -months-years