USMLE STEP 2 CK TEST PAPER 2026 FULL
QUESTIONS AND ANSWERS VERIFIED STUDY
GUIDE FINAL PREP 400
◉ CNS lymphoma.
Answer: HIV+ patient presents with EBV DNA in CSF, MRI shows a
weakly ring-enhancing mass that is solitary and periventricular
◉ Toxoplasmosis.
Answer: MRI of HIV+ patient shows multiple, ring-enhancing,
spherical lesions in the basal ganglia
◉ Squamous cell carcinoma.
Answer: Former smoker presents with anorexia, constipation, inc.
thirst, easy fatigability, hypercalcemia d/t PTHrP , hilar mass on CXR
◉ Acute respiratory distress syndrome.
Answer: Paitent presents with dec. lung compliance, pulmonary htn,
hypoxemia with PaO2/FiO2 ratio =<300 mmHg
◉ Central retinal artery occlusion.
,Answer: Patien presents with loss of monocular vision, treated with
ocular massage and high flow oxygen
◉ Subacute thyroiditis (de Quervain).
Answer: Patient has prominent fever, hyperthyroid symptoms,
painful/tender goiter
◉ Disseminated histoplasmosis.
Answer: HIV+ patient presents with weight loss, pulmonary
symptoms (cough, dyspnea), mucocutaneous lesions, HSM,
pancytopenia, transaminitis, inc. LDH and ferritin
◉ Relative risk.
Answer: Measure of association used in cohort studies
◉ Aortic regurgitation.
Answer: Diastolic decrescendo murmur, best heart while pt is sitting
up, leaning forward and holding breath in full expiration
◉ Hypertrophic cardiomyopathy.
Answer: Presents with a harsh crescendo-decreascendo systolic
murmur best hear tat the apex and LLSB, murmur inc. with valsalva
or abrupt standing
, ◉ Congenital bicuspid aortic valve.
Answer: MC cause of isolated AR in young adults in developed
countries
◉ Rheumatic heart disease.
Answer: MC cause of AR in the developing world
◉ Parapneumonic effusion.
Answer: Patient has SOB, low-grade fever, pleural effusion with fluid
with pH >7.2, normal glucose, WBC <50k
◉ Pleural fluid protein/serum ratio >0.5, pleural fluid LDH/serum
ratio >0.6, pleural fluid LDH >2/3 ULN.
Answer: Light criteria for exudative pleural effusions
◉ Myasthenia gravis.
Answer: Ice pack is applied over the eyelids for several minutes,
leading to an improvement in ptosis
◉ Acute angle closure glaucoma.
Answer: Patient has HA, nausea, eye pain and nonreactive mid-
dilated pupil
QUESTIONS AND ANSWERS VERIFIED STUDY
GUIDE FINAL PREP 400
◉ CNS lymphoma.
Answer: HIV+ patient presents with EBV DNA in CSF, MRI shows a
weakly ring-enhancing mass that is solitary and periventricular
◉ Toxoplasmosis.
Answer: MRI of HIV+ patient shows multiple, ring-enhancing,
spherical lesions in the basal ganglia
◉ Squamous cell carcinoma.
Answer: Former smoker presents with anorexia, constipation, inc.
thirst, easy fatigability, hypercalcemia d/t PTHrP , hilar mass on CXR
◉ Acute respiratory distress syndrome.
Answer: Paitent presents with dec. lung compliance, pulmonary htn,
hypoxemia with PaO2/FiO2 ratio =<300 mmHg
◉ Central retinal artery occlusion.
,Answer: Patien presents with loss of monocular vision, treated with
ocular massage and high flow oxygen
◉ Subacute thyroiditis (de Quervain).
Answer: Patient has prominent fever, hyperthyroid symptoms,
painful/tender goiter
◉ Disseminated histoplasmosis.
Answer: HIV+ patient presents with weight loss, pulmonary
symptoms (cough, dyspnea), mucocutaneous lesions, HSM,
pancytopenia, transaminitis, inc. LDH and ferritin
◉ Relative risk.
Answer: Measure of association used in cohort studies
◉ Aortic regurgitation.
Answer: Diastolic decrescendo murmur, best heart while pt is sitting
up, leaning forward and holding breath in full expiration
◉ Hypertrophic cardiomyopathy.
Answer: Presents with a harsh crescendo-decreascendo systolic
murmur best hear tat the apex and LLSB, murmur inc. with valsalva
or abrupt standing
, ◉ Congenital bicuspid aortic valve.
Answer: MC cause of isolated AR in young adults in developed
countries
◉ Rheumatic heart disease.
Answer: MC cause of AR in the developing world
◉ Parapneumonic effusion.
Answer: Patient has SOB, low-grade fever, pleural effusion with fluid
with pH >7.2, normal glucose, WBC <50k
◉ Pleural fluid protein/serum ratio >0.5, pleural fluid LDH/serum
ratio >0.6, pleural fluid LDH >2/3 ULN.
Answer: Light criteria for exudative pleural effusions
◉ Myasthenia gravis.
Answer: Ice pack is applied over the eyelids for several minutes,
leading to an improvement in ptosis
◉ Acute angle closure glaucoma.
Answer: Patient has HA, nausea, eye pain and nonreactive mid-
dilated pupil
