KATZUNG'S BASIC AND
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is participating in a clinical trial involving an
investigational medication. Which action best demonstrates
adherence to ethical principles during the study?
A. Administer the medication even if informed consent has not
been documented because the provider ordered it.
B. Verify that informed consent has been obtained before
administering the investigational medication.
C. Encourage the participant to remain in the study regardless
of adverse effects.
D. Share the participant's study information with family
members to improve support.
Correct Answer: B
Rationale:
Obtaining and verifying informed consent is a fundamental
ethical requirement before administering an investigational
medication. Participants must voluntarily agree after receiving
adequate information about potential benefits, risks, and
alternatives. Option A violates ethical and legal standards.
Option C disregards the participant's right to withdraw from
research at any time. Option D violates confidentiality unless
the participant has given explicit permission.
,Question 2
A nurse is teaching a patient about the purpose of Phase III
clinical trials. Which statement by the nurse is most accurate?
A. "These studies are conducted only after the medication is
available without a prescription."
B. "These studies compare the medication with existing
therapies in a larger population to evaluate effectiveness and
safety."
C. "These studies are performed only in laboratory animals."
D. "These studies determine the chemical structure of the
medication."
Correct Answer: B
Rationale:
Phase III trials typically involve large groups of participants and
evaluate therapeutic effectiveness while continuing to assess
safety, often comparing the new medication with standard
therapy. Option A refers to post-marketing activities rather than
Phase III studies. Option C describes preclinical research. Option
D occurs much earlier during drug discovery.
Question 3
A patient asks why a newly prescribed medication has both a
generic and a brand name. What is the nurse's best response?
, A. "The generic and brand medications always contain different
active ingredients."
B. "The generic name identifies the active drug, while
manufacturers market the medication under one or more brand
names."
C. "Brand names are assigned by healthcare providers."
D. "Generic names change depending on the pharmacy."
Correct Answer: B
Rationale:
The generic name identifies the medication's active ingredient,
whereas manufacturers market the product under brand
names. Option A is incorrect because approved generic and
brand products contain the same active ingredient. Option C is
inaccurate because manufacturers select brand names subject
to regulatory approval. Option D is incorrect because generic
names remain consistent regardless of pharmacy.
Question 4
A nurse reviews a newly prescribed medication and notes that it
has a boxed warning. What is the nurse's priority action?
A. Refuse to administer the medication.
B. Ignore the warning if the dose is low.
CLINICAL PHARMACOLOGY
16TH EDITION
• AUTHOR(S)TODD W.
VANDERAH
TEST BANK
,Question 1
A nurse is participating in a clinical trial involving an
investigational medication. Which action best demonstrates
adherence to ethical principles during the study?
A. Administer the medication even if informed consent has not
been documented because the provider ordered it.
B. Verify that informed consent has been obtained before
administering the investigational medication.
C. Encourage the participant to remain in the study regardless
of adverse effects.
D. Share the participant's study information with family
members to improve support.
Correct Answer: B
Rationale:
Obtaining and verifying informed consent is a fundamental
ethical requirement before administering an investigational
medication. Participants must voluntarily agree after receiving
adequate information about potential benefits, risks, and
alternatives. Option A violates ethical and legal standards.
Option C disregards the participant's right to withdraw from
research at any time. Option D violates confidentiality unless
the participant has given explicit permission.
,Question 2
A nurse is teaching a patient about the purpose of Phase III
clinical trials. Which statement by the nurse is most accurate?
A. "These studies are conducted only after the medication is
available without a prescription."
B. "These studies compare the medication with existing
therapies in a larger population to evaluate effectiveness and
safety."
C. "These studies are performed only in laboratory animals."
D. "These studies determine the chemical structure of the
medication."
Correct Answer: B
Rationale:
Phase III trials typically involve large groups of participants and
evaluate therapeutic effectiveness while continuing to assess
safety, often comparing the new medication with standard
therapy. Option A refers to post-marketing activities rather than
Phase III studies. Option C describes preclinical research. Option
D occurs much earlier during drug discovery.
Question 3
A patient asks why a newly prescribed medication has both a
generic and a brand name. What is the nurse's best response?
, A. "The generic and brand medications always contain different
active ingredients."
B. "The generic name identifies the active drug, while
manufacturers market the medication under one or more brand
names."
C. "Brand names are assigned by healthcare providers."
D. "Generic names change depending on the pharmacy."
Correct Answer: B
Rationale:
The generic name identifies the medication's active ingredient,
whereas manufacturers market the product under brand
names. Option A is incorrect because approved generic and
brand products contain the same active ingredient. Option C is
inaccurate because manufacturers select brand names subject
to regulatory approval. Option D is incorrect because generic
names remain consistent regardless of pharmacy.
Question 4
A nurse reviews a newly prescribed medication and notes that it
has a boxed warning. What is the nurse's priority action?
A. Refuse to administer the medication.
B. Ignore the warning if the dose is low.
