Test Bank for Rodak's Hematology Clinical Principles and Applications 7th Edition by Elaine M. Keohane, Michelle Montgomery Preston| 9780323549639| All Chapters 1-43| LATEST

TEST BANK
RODAK'S HEMATOLOGY CLINICAL
PRINCIPLES AND APPLICATIONS

,Table of Contents
Part I. Introduction to Hematology

1. An Overview of Clinical Laboratory Hematology

2. Patient Safety in Hematology and Hemostasis

3. Quality Assurance in Hematology and Hemostasis Testing

Part II. Blood Cell Production, Structure, and Function

4. Cell Structure and Function

5. Hematopoiesis

6. Erythrocyte Production and Destruction

7. Erythrocyte Metabolism and Membrane Structure and Function

8. Hemoglobin Metabolism

9. Iron Kinetics and Laboratory Assessment

10. Leukocyte Development, Kinetics, and Functions

11. Platelet Production, Structure, and Function

Part III. Laboratory Evaluation of Blood Cells

12. Manual, Semiautomated, and Point-of-Care Testing in Hematology

13. Automated Blood Cell Analysis

14. Examination of the Peripheral Blood Film and Correlation With the Complete Blood Count

15. Bone Marrow Examination

Part IV. Erythrocyte Disorders

16. Anemias: Red Blood Cell Morphology and Approach to Diagnosis

17. Disorders of Iron Kinetics and Heme Metabolism

,18. Anemias Caused by Defects of DNA Metabolism

19. Bone Marrow Failure

20. Introduction to Increased Destruction of Erythrocytes

21. Intrinsic Defects Leading to Increased Erythrocyte Destruction

22. Extrinsic Defects Leading to Increased Erythrocyte Destruction - Nonimmune Causes

23. Extrinsic Defects Leading to Increased Erythrocyte Destruction - Immune Causes

24. Hemoglobinopathies (Structural Defects in Hemoglobin)

25. Thalassemias

Part V. Leukocyte Disorders

26. Nonmalignant Leukocyte Disorders

27. Introduction to Hematologic Neoplasms

28. Flow Cytometric Analysis in Hematologic Disorders

29. Molecular Diagnostics in Hematopathology

30. Cytogenetics

31. Acute Leukemias

32. Myeloproliferative Neoplasms

33. Myelodysplastic Neoplasms

34. Mature Lymphoid Neoplasms

Part VI. Hemostasis and Thrombosis

35. Normal Hemostasis

36. Hemorrhagic Disorders and Laboratory Assessment

37. Qualitative Disorders of Platelets and Vasculature

,38. Quantitative Disorders of Platelets: Thrombocytopenia and Thrombocytosis

39. Thrombotic Disorders and Laboratory Assessment

40. Antithrombotic Therapies and Laboratory Assessment

41. Laboratory Evaluation of Hemostasis

42. Hemostasis and Coagulation Instrumentation

Part VII. Hematology and Hemostasis in Selected Populations

43. Hematology and Hemostasis in the Pediatric, Pregnant, Geriatric, and Transgender
Populations

,PART I: INTRODUCTION TO HEMATOLOGY



CHAPTER 1: AN OVERVIEW OF CLINICAL LABORATORY HEMATOLOGY



MULTIPLE CHOICE QUESTIONS



Question 1 (Easy)
Which of the following best describes the primary focus of clinical laboratory hematology?

A) The study of blood coagulation disorders exclusively
B) The study of blood cells, their production, morphology, and diseases affecting them
C) The study of serum proteins and electrolytes
D) The analysis of urine sediment for cellular elements

ANSWER: B
Rationale: Clinical laboratory hematology is the branch of laboratory medicine focused on the
study of blood cells—including their production (hematopoiesis), structure (morphology),
function, and the diseases that affect them. Coagulation is a related but separate specialty
(hemostasis). Serum proteins and urine sediment analysis fall under clinical chemistry and
urinalysis, respectively.



Question 2 (Easy)
Which of the following is the most commonly ordered hematology test in a clinical laboratory?

A) Reticulocyte count
B) Erythrocyte sedimentation rate (ESR)
C) Complete blood count (CBC)
D) Bone marrow biopsy

ANSWER: C
Rationale: The complete blood count (CBC) is the single most commonly ordered laboratory
test across virtually all clinical settings. It provides a comprehensive overview of all major
cellular components of blood—red blood cells, white blood cells, and platelets—making it
invaluable in screening, diagnosis, and monitoring of a wide range of conditions.



Question 3 (Easy)
The term "hematocrit" refers to which of the following measurements?

, A) The total number of white blood cells per microliter of blood
B) The proportion of blood volume occupied by red blood cells, expressed as a percentage
C) The average hemoglobin concentration within a single red blood cell
D) The total number of platelets per microliter of blood

ANSWER: B
Rationale: The hematocrit (Hct), also called the packed cell volume (PCV), represents the
percentage of total blood volume that is occupied by red blood cells (erythrocytes). It is directly
influenced by RBC count and mean corpuscular volume (MCV), and it helps in the classification
and monitoring of anemia and polycythemia.



Question 4 (Easy)
Which of the following anticoagulants is the preferred additive for tubes used in routine
hematology CBC testing?

A) Sodium citrate
B) Heparin
C) EDTA (ethylenediaminetetraacetic acid)
D) Potassium oxalate

ANSWER: C
Rationale: EDTA (ethylenediaminetetraacetic acid) is the anticoagulant of choice for routine
CBC testing. It chelates calcium ions to prevent clotting while preserving cellular morphology
and preventing platelet clumping better than other anticoagulants. Sodium citrate is used for
coagulation studies, and heparin can cause platelet clumping and cell morphology artifacts.



Question 5 (Easy)
Which blood cell type is the most numerous in a normal peripheral blood smear?

A) Lymphocytes
B) Monocytes
C) Neutrophils
D) Platelets (thrombocytes)

ANSWER: C
Rationale: Among the white blood cells (leukocytes), neutrophils are the most abundant,
comprising approximately 50–70% of the total white blood cell differential count in a healthy
adult. While platelets are more numerous in total count, among the leukocyte population
specifically, neutrophils predominate and are the primary first-line defenders of the innate
immune system.