NSGl 533/l NSG533l Examl 2l –l Advancedl
Pharmacologyl Review|l Wilkesl (Latestl
2026/l 2027l Update)l 100%l Verifiedl
Questionsl &l Answersl |l Gradel A
Q:l Understandl whenl youl wouldl usel acetaminophenl versusl anl NSAIDl orl anl NSAIDl
insteadl ofl acetaminopehn
Answer:
NSAIDsl workl bestl onl inflammatoryl painl orl painl mediatedl byl prostaglandinsl (RA,l
menstruall andl post-surgicall pain)l andl bonyl metastasis.l NSAIDSl comel withl increasedl
GIBl riskl andl renall impairment.l
APAPl isl al goodl firstl linel forl mildl tol moderatel painl andl consideredl thel firstl linel inl
lowl backl painl andl osteoarthritic.l APAPl hepatotoxicityl hasl occuredl inl thosel w.l liverl
injuryl orl chronicl drinkers.
Q:l Whatl classl ofl prophylaxisl forl migrainesl shouldl bel avoidedl inl asthmatics?
Answer:
Betal blockersl wouldl usuallyl bel al medicationl usedl inl thel prophylaxisl ofl migrainesl butl
thisl wouldl notl bel thel bestl choicel inl anl asthmatic.
Q:l Whatl couldl youl usel forl prophylaxisl ofl migraines?
Answer:
,-beta-blockersl ifl notl contraindicatedl (orl CCB)
-low-dosel TCAsl (amitriptyline,l venlafaxine)
-antiepilepticsl (topiramate,l valproicl acid,l divalproexl sodium)
Q:l Whatl couldl youl usel inl thel treatmentl ofl acutel migrainel symptoms?
Answer:
mildl tol moderate:l APAP,l ASAl orl combinationl productsl w/l caffeine
moderatel tol severe:l triptansl arel 1stl line
Q:l Whatl absolutel contraindicationsl wouldl preventl youl froml usingl triptans?
Answer:
Hxl ofl neurologicl focality
Stroke
Poorlyl controlledl HTN
Unstablel angina
Q:l Whatl triggersl wouldl youl wantl tol telll al patientl tol avoidl tol helpl preventl migrainesl
(non-pharmacologicl interventions):
Answer:
-emotionall stress
, -sleepl excessl orl deficient
-strongl smells
-alcohol
-caffeinel
-fermentedl foods
-nitrates
-tobacco
-MSG
Q:l Knowl whatl arel thel "redl flagl symptoms"l ofl headachesl whichl signifyl thel needl forl
urgentl medicall care:
Answer:
-newl onsetl sudden,l severel pain
-systemicl signsl (fever,l weightl loss,l HTN)
-focall neurol symptoms
-papilledemal (swellingl ofl bothl opticl discsl inl eyesl d/tl increasedl ICP
-cough/l exertionl triggeredl byl HA
-pregnancyl orl postpartuml state
-HIV
-cancerl patients
-seizurel activity
Pharmacologyl Review|l Wilkesl (Latestl
2026/l 2027l Update)l 100%l Verifiedl
Questionsl &l Answersl |l Gradel A
Q:l Understandl whenl youl wouldl usel acetaminophenl versusl anl NSAIDl orl anl NSAIDl
insteadl ofl acetaminopehn
Answer:
NSAIDsl workl bestl onl inflammatoryl painl orl painl mediatedl byl prostaglandinsl (RA,l
menstruall andl post-surgicall pain)l andl bonyl metastasis.l NSAIDSl comel withl increasedl
GIBl riskl andl renall impairment.l
APAPl isl al goodl firstl linel forl mildl tol moderatel painl andl consideredl thel firstl linel inl
lowl backl painl andl osteoarthritic.l APAPl hepatotoxicityl hasl occuredl inl thosel w.l liverl
injuryl orl chronicl drinkers.
Q:l Whatl classl ofl prophylaxisl forl migrainesl shouldl bel avoidedl inl asthmatics?
Answer:
Betal blockersl wouldl usuallyl bel al medicationl usedl inl thel prophylaxisl ofl migrainesl butl
thisl wouldl notl bel thel bestl choicel inl anl asthmatic.
Q:l Whatl couldl youl usel forl prophylaxisl ofl migraines?
Answer:
,-beta-blockersl ifl notl contraindicatedl (orl CCB)
-low-dosel TCAsl (amitriptyline,l venlafaxine)
-antiepilepticsl (topiramate,l valproicl acid,l divalproexl sodium)
Q:l Whatl couldl youl usel inl thel treatmentl ofl acutel migrainel symptoms?
Answer:
mildl tol moderate:l APAP,l ASAl orl combinationl productsl w/l caffeine
moderatel tol severe:l triptansl arel 1stl line
Q:l Whatl absolutel contraindicationsl wouldl preventl youl froml usingl triptans?
Answer:
Hxl ofl neurologicl focality
Stroke
Poorlyl controlledl HTN
Unstablel angina
Q:l Whatl triggersl wouldl youl wantl tol telll al patientl tol avoidl tol helpl preventl migrainesl
(non-pharmacologicl interventions):
Answer:
-emotionall stress
, -sleepl excessl orl deficient
-strongl smells
-alcohol
-caffeinel
-fermentedl foods
-nitrates
-tobacco
-MSG
Q:l Knowl whatl arel thel "redl flagl symptoms"l ofl headachesl whichl signifyl thel needl forl
urgentl medicall care:
Answer:
-newl onsetl sudden,l severel pain
-systemicl signsl (fever,l weightl loss,l HTN)
-focall neurol symptoms
-papilledemal (swellingl ofl bothl opticl discsl inl eyesl d/tl increasedl ICP
-cough/l exertionl triggeredl byl HA
-pregnancyl orl postpartuml state
-HIV
-cancerl patients
-seizurel activity
