FORENSIC TOXICOLOGY FINAL EXAM QUESTIONS WITH CORRECT
ANSWERS
Jean Stas - ans-Isolated nicotine from organ tissues
xz xz xz xz xz xz xz
Robert Borkenstein - ans- xz xz xz
With Rolla Harger, developed the drunkometer. The precursor to the breathalyzer
xz xz xz xz xz xz xz xz xz xz
Matthieu Orfila - ans- xz xz xz
Father of toxicology; attempted to categorize poisons in "Traite de Poisons"
xz xz xz xz xz xz xz xz xz xz
Paracelsus - ans-"The dose determines the poison" xz xz xz xz xz xz
James March - ans-Inventor of the test for arsenic
xz xz xz xz xz xz xz xz
Alexander Gettler - ans-Father of American Toxicology xz xz xz xz xz xz
Peripheral blood - ans-This sample will give better (more interpretable) results
xz xz xz xz xz xz xz xz xz xz
What is the biggest problem for DFSA (drug facilitated sexual assault cases) - ans-24-
xz xz xz xz xz xz xz xz xz xz xz xz xz
48 hour cutoff
xz xz
True or False: toxicological postmortem case analysis is very different than in DUI cases -
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
ans-False
xz
Tox Lab A uses predominantly LLE to confirm positive cases (not SPE). What could be two
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
positive reasons for its decision? - ans-Cheaper and wide variety choice of solvents
xz xz xz xz xz xz xz xz xz xz xz xz
Tox Lab B uses predominately SPE to confirm positive cases (not LLE). What could be two
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
positive reasons for its decision? - ans-More selective and better recovery
xz xz xz xz xz xz xz xz xz xz
What is a DRE officer? - ans-a police officer with special training to detect a class of drugs
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
2 examples of phase 1 metabolism - ans-hydroxylation and hydrolysis
xz xz xz xz xz xz xz xz xz
A compound that exhibits zero order kinetics - ans-alcohol
xz xz xz xz xz xz xz xz
Acetylation is an example of a phase_______ process - ans-2 xz xz xz xz xz xz xz xz xz
As an acidic drug travels down the length of the small intestine, the amount of drug in the no
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
n-ionized form would be expected to... - ans-decrease xz xz xz xz xz xz xz
, low volume of distribution - ans-
xz xz xz xz xz
the amount of fluid that a drug would distribute into if all stayed in the blood
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
intravenous - ans-entire dose get absorbed into the bloodstream xz xz xz xz xz xz xz xz
epoxide formation of a drug is an example of phase _____ metabolism - ans-1
xz xz xz xz xz xz xz xz xz xz xz xz xz
morphine glucuronide - ans-has an active metabolite xz xz xz xz xz xz
Constant fraction of the dose eliminated over time - ans-1st order kinetics
xz xz xz xz xz xz xz xz xz xz xz
codeine - ans-could produce a positive test for morphine
xz xz xz xz xz xz xz xz
lipophilic drugs - ans-higher volume of distribution than a hydrophilic one
xz xz xz xz xz xz xz xz xz xz
4 phases of pharmacokinetics - ans-absorption, distribution, metabolism, elimination
xz xz xz xz xz xz xz xz
Drugs are more rapidly absorbed if they are in their... - ans-unionized form
xz xz xz xz xz xz xz xz xz xz xz xz
metabolism of a drug may occur before entry into the heart or general circulation - ans-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
first pass effect xz xz
Marijuana (THC) reaches its maximum concentration in the blood (very quickly) within minu
xz xz xz xz xz xz xz xz xz xz xz xz
tes of ingestion. Why? - ans-efficient route of absorption- inhalation
xz xz xz xz xz xz xz xz xz
Why can THC be detected for days or weeks later in the blood? - ans-protein bound-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
sticks to tissues in the body for a long time
xz xz xz xz xz xz xz xz xz xz
purpose of Phase 2 metabolism - ans-to facilitate elimination from body
xz xz xz xz xz xz xz xz xz xz
At equilibrium, the concentration of ethanol is _______ than its concentration in urine - ans-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
lower in blood (ethanol follows water)
xz xz xz xz xz
What can you do to improve fronting? - ans-
xz xz xz xz xz xz xz xz
change reconstituting solvent to match the solvent of the LC system
xz xz xz xz xz xz xz xz xz xz
shift to a shorter wavelength - ans-hypsochromic
xz xz xz xz xz xz
3 possible causes from deviations from beer-lambert law? - ans-
xz xz xz xz xz xz xz xz xz
high concentrations, scattering, fluorescence and radiation reactions
xz xz xz xz xz xz
For gradient HPLC as retention time increases peak width... - ans-remains constant
xz xz xz xz xz xz xz xz xz xz xz
For isothermal GC, the peak width.... - ans-increases
xz xz xz xz xz xz xz
Aniline has an amino group attached to the aromatic ring called a... - ans-auxochrome
xz xz xz xz xz xz xz xz xz xz xz xz xz
ANSWERS
Jean Stas - ans-Isolated nicotine from organ tissues
xz xz xz xz xz xz xz
Robert Borkenstein - ans- xz xz xz
With Rolla Harger, developed the drunkometer. The precursor to the breathalyzer
xz xz xz xz xz xz xz xz xz xz
Matthieu Orfila - ans- xz xz xz
Father of toxicology; attempted to categorize poisons in "Traite de Poisons"
xz xz xz xz xz xz xz xz xz xz
Paracelsus - ans-"The dose determines the poison" xz xz xz xz xz xz
James March - ans-Inventor of the test for arsenic
xz xz xz xz xz xz xz xz
Alexander Gettler - ans-Father of American Toxicology xz xz xz xz xz xz
Peripheral blood - ans-This sample will give better (more interpretable) results
xz xz xz xz xz xz xz xz xz xz
What is the biggest problem for DFSA (drug facilitated sexual assault cases) - ans-24-
xz xz xz xz xz xz xz xz xz xz xz xz xz
48 hour cutoff
xz xz
True or False: toxicological postmortem case analysis is very different than in DUI cases -
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
ans-False
xz
Tox Lab A uses predominantly LLE to confirm positive cases (not SPE). What could be two
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
positive reasons for its decision? - ans-Cheaper and wide variety choice of solvents
xz xz xz xz xz xz xz xz xz xz xz xz
Tox Lab B uses predominately SPE to confirm positive cases (not LLE). What could be two
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
positive reasons for its decision? - ans-More selective and better recovery
xz xz xz xz xz xz xz xz xz xz
What is a DRE officer? - ans-a police officer with special training to detect a class of drugs
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
2 examples of phase 1 metabolism - ans-hydroxylation and hydrolysis
xz xz xz xz xz xz xz xz xz
A compound that exhibits zero order kinetics - ans-alcohol
xz xz xz xz xz xz xz xz
Acetylation is an example of a phase_______ process - ans-2 xz xz xz xz xz xz xz xz xz
As an acidic drug travels down the length of the small intestine, the amount of drug in the no
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
n-ionized form would be expected to... - ans-decrease xz xz xz xz xz xz xz
, low volume of distribution - ans-
xz xz xz xz xz
the amount of fluid that a drug would distribute into if all stayed in the blood
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
intravenous - ans-entire dose get absorbed into the bloodstream xz xz xz xz xz xz xz xz
epoxide formation of a drug is an example of phase _____ metabolism - ans-1
xz xz xz xz xz xz xz xz xz xz xz xz xz
morphine glucuronide - ans-has an active metabolite xz xz xz xz xz xz
Constant fraction of the dose eliminated over time - ans-1st order kinetics
xz xz xz xz xz xz xz xz xz xz xz
codeine - ans-could produce a positive test for morphine
xz xz xz xz xz xz xz xz
lipophilic drugs - ans-higher volume of distribution than a hydrophilic one
xz xz xz xz xz xz xz xz xz xz
4 phases of pharmacokinetics - ans-absorption, distribution, metabolism, elimination
xz xz xz xz xz xz xz xz
Drugs are more rapidly absorbed if they are in their... - ans-unionized form
xz xz xz xz xz xz xz xz xz xz xz xz
metabolism of a drug may occur before entry into the heart or general circulation - ans-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
first pass effect xz xz
Marijuana (THC) reaches its maximum concentration in the blood (very quickly) within minu
xz xz xz xz xz xz xz xz xz xz xz xz
tes of ingestion. Why? - ans-efficient route of absorption- inhalation
xz xz xz xz xz xz xz xz xz
Why can THC be detected for days or weeks later in the blood? - ans-protein bound-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
sticks to tissues in the body for a long time
xz xz xz xz xz xz xz xz xz xz
purpose of Phase 2 metabolism - ans-to facilitate elimination from body
xz xz xz xz xz xz xz xz xz xz
At equilibrium, the concentration of ethanol is _______ than its concentration in urine - ans-
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
lower in blood (ethanol follows water)
xz xz xz xz xz
What can you do to improve fronting? - ans-
xz xz xz xz xz xz xz xz
change reconstituting solvent to match the solvent of the LC system
xz xz xz xz xz xz xz xz xz xz
shift to a shorter wavelength - ans-hypsochromic
xz xz xz xz xz xz
3 possible causes from deviations from beer-lambert law? - ans-
xz xz xz xz xz xz xz xz xz
high concentrations, scattering, fluorescence and radiation reactions
xz xz xz xz xz xz
For gradient HPLC as retention time increases peak width... - ans-remains constant
xz xz xz xz xz xz xz xz xz xz xz
For isothermal GC, the peak width.... - ans-increases
xz xz xz xz xz xz xz
Aniline has an amino group attached to the aromatic ring called a... - ans-auxochrome
xz xz xz xz xz xz xz xz xz xz xz xz xz
