NEU 365D || 100% Valid Solutions.
Relationships between doses and responses are discussed in terms correct answers log curves
Properties of LDR Curve correct answers 1. These curves describe the dose-response relationship
over a wide range of doses.
2. LDR curves are typically sigmoidal ("S" shaped). The middle section is approximately
straight, facilitating statistical analyses.
3. The same effect is produced by different drugs that act by identical or at least similar
mechanisms.
α correct answers intrinsic activity; ability of a drug-receptor complex to produce a maximum
functional respond
K (capital) correct answers Potency, not binding affintity
Response Formula correct answers Response = (α[D][R])/K+[D]
slope of double reciprocal plot correct answers K / Respmax
What to do against quantal effects correct answers Either the percentage or actual number of
patients responding to a given dose of a drug is recorded.
Graded to quantal effects correct answers Graded effects (eg. heart rate) can be converted to
quantal effects. Example: drug effect on heart rate measure is graded, but % subjects showing
50% increase in heart rate in response to drug is quantal.
mean effective dose correct answers ED50
, Safe Drugs correct answers Drugs are considered safe if their toxicity LDR curves are
considerably to the right of their efficacy LDR curves.
TI = (TD50)/(ED50)
this can also be examined looking at the lethal dose LD50 as follows:
(LD50)/(ED50)
Large
It is the range between he minimum effective therapeutic concentration and the minimum toxic
concentration. correct answers You want large value. However, it's not end all be all
measurement as high dosage can be toxic and helpful for same drugs or helpful for others
Certain safety factor (CSF) = TD1 / ED99 correct answers You want low value; Much better
measurement
Do TI and CSF assumptions have to be parallel correct answers Evaluations of TI and CSF do
not require assumptions of LDR curve parallelism.
Paul Ehrlich correct answers Paul Ehrlich more than a century ago coined the term "magic
bullet" to describe the specificity of drug action.
nonspecific binding site correct answers Defined as any body component that a drug binds to
without leading to an effect (remember albumin)
Specific binding site correct answers Binding occurs to a site that leads to an effect on the cell or
organism that component is said to be a receptor and the binding is specific.
Relationships between doses and responses are discussed in terms correct answers log curves
Properties of LDR Curve correct answers 1. These curves describe the dose-response relationship
over a wide range of doses.
2. LDR curves are typically sigmoidal ("S" shaped). The middle section is approximately
straight, facilitating statistical analyses.
3. The same effect is produced by different drugs that act by identical or at least similar
mechanisms.
α correct answers intrinsic activity; ability of a drug-receptor complex to produce a maximum
functional respond
K (capital) correct answers Potency, not binding affintity
Response Formula correct answers Response = (α[D][R])/K+[D]
slope of double reciprocal plot correct answers K / Respmax
What to do against quantal effects correct answers Either the percentage or actual number of
patients responding to a given dose of a drug is recorded.
Graded to quantal effects correct answers Graded effects (eg. heart rate) can be converted to
quantal effects. Example: drug effect on heart rate measure is graded, but % subjects showing
50% increase in heart rate in response to drug is quantal.
mean effective dose correct answers ED50
, Safe Drugs correct answers Drugs are considered safe if their toxicity LDR curves are
considerably to the right of their efficacy LDR curves.
TI = (TD50)/(ED50)
this can also be examined looking at the lethal dose LD50 as follows:
(LD50)/(ED50)
Large
It is the range between he minimum effective therapeutic concentration and the minimum toxic
concentration. correct answers You want large value. However, it's not end all be all
measurement as high dosage can be toxic and helpful for same drugs or helpful for others
Certain safety factor (CSF) = TD1 / ED99 correct answers You want low value; Much better
measurement
Do TI and CSF assumptions have to be parallel correct answers Evaluations of TI and CSF do
not require assumptions of LDR curve parallelism.
Paul Ehrlich correct answers Paul Ehrlich more than a century ago coined the term "magic
bullet" to describe the specificity of drug action.
nonspecific binding site correct answers Defined as any body component that a drug binds to
without leading to an effect (remember albumin)
Specific binding site correct answers Binding occurs to a site that leads to an effect on the cell or
organism that component is said to be a receptor and the binding is specific.
