NEU 365W Exams 1-3 Multiple Choice & True/False || with 100%
Correct Answers.
According to a UK multicriteria analysis of drug abuse, which drug is the most harmful to
society and the individual?
a) Heroin
b) Crack cocaine
c) LSD
d) Alcohol
e) Methamphetamine correct answers d) Alcohol
Which of the following is NOT a useful measurement for modeling ethanol withdrawal in
rodents?
a) Handling-induced seizures
b) Tail tremors
c) General hyperactivity
d) Loss of righting reflex correct answers d) Loss of righting reflex
Which drug has the highest addiction liability?
a) Alcohol
b) Cocaine
c) Heroin
d) Nicotine
e) Methamphetamine correct answers c) Heroin
When initiating drug use, people first take the drug for pleasure and gratification and then shift to
_____________ reinforcement, where using the drug is used to alleviate __________________.
a) Positive; stress and anxiety
,b) Negative; stress and anxiety
c) Positive; craving
d) Negative; craving correct answers b) Negative; stress and anxiety
Why do polymorphisms in alcohol metabolism genes (for example ADH2 or ALDH1) provide
protection against alcohol use disorder? Excess what in the bloodstream causes the unpleasant
effects of drinking?
a) Acetate
b) Acetaldehyde
c) Alcohol dehydrogenase
d) Alcohol correct answers b) Acetaldehyde
Rank routes of administration from the fastest method to the slowest method to get high
concentrations of drug in the blood stream.
a) Oral, Intravenous, Smoked, Intranasal
b) Smoked, Oral, Intranasal, Intravenous
c) Intravenous, Intranasal, Oral
d) Smoked, Oral, Intranasal correct answers c) Intravenous, Intranasal, Oral
Alcohol displaces __________ to bind to LUSH, which is a protein found in _________.
a) water, Drosophila
b) GABA, bacteria
c) water, bacteria
d) zinc, humans correct answers a) water, Drosophila
Membranes are ___________________ and therefore it is harder for ____________ drugs to
cross.
a) Hydrophobic; ionized
,b) Hydrophobic; uncharged
c) Hydrophilic; ionized
d) Hydrophilic; uncharged correct answers a) Hydrophobic; ionized
Why are slo-1 knockout mice not particularly useful for studying alcohol addiction?
a) They die prenatally
b) They are viable but have too many health problems to undergo drinking experiments
c) They drink much more than wild-type mice
d) They are much more sensitive to alcohol than wild-type mice correct answers b) They are
viable but have too many health problems to undergo drinking experiments
Overall, ethanol decreases excitability in the brain. What are its effects on receptors in the brain?
a) Inhibits inhibitory receptors and inhibits excitatory receptors
b) Enhances inhibitory receptors and enhances excitatory receptors
c) Enhances inhibitory receptors and inhibits excitatory receptors
d) Inhibits inhibitory receptors and enhances excitatory receptors. correct answers c) Enhances
inhibitory receptors and inhibits excitatory receptors
The structure for Acetylsalicylic acid is shown. Based on the structure where will the majority of
drug absorption occur?
a) Stomach
b) Small Intestine
c) Liver
d) Kidney
Large Intestine correct answers a) Stomach
Acetylsalicylic acid will be absorbed in the organ in Question #11 because the drug can be
___________________ and remain ___________________.
, a) Protonated; Charged
b) Deprotonated; Charged
c) Protonated; Uncharged
d) Deprotonated; Uncharged correct answers c) Protonated; Uncharged
Naltrexone is one of three FDA-approved drugs for alcohol use disorder. What is the mechanism
of action of naltrexone?
a) GABA receptor agonist
b) Dopamine receptor antagonist
c) Opioid receptor antagonist
d) NMDA receptor antagonist correct answers c) Opioid receptor antagonist
What is the most important variable affecting absorption of drugs?
a) pH of the drug
b) Ionization of the drug
c) Rate of stomach emptying
d) Surface Area
e) Both C & D. correct answers c) Rate of stomach emptying
How does ethanol affect the probability of BK channel opening?
a) Ethanol irreversibly increases the probability of BK channel opening
b) Ethanol reversibly increases the probability of BK channel opening
c) Ethanol irreversibly decreases the probability of BK channel opening
d) Ethanol reversibly decreases the probability of BK channel opening correct answers b)
Ethanol reversibly increases the probability of BK channel opening
What was used to determine that ethanol modulation of the GABRA2 subunit is important for
specific behaviors including ethanol conditioned taste aversion and motor stimulation?
Correct Answers.
According to a UK multicriteria analysis of drug abuse, which drug is the most harmful to
society and the individual?
a) Heroin
b) Crack cocaine
c) LSD
d) Alcohol
e) Methamphetamine correct answers d) Alcohol
Which of the following is NOT a useful measurement for modeling ethanol withdrawal in
rodents?
a) Handling-induced seizures
b) Tail tremors
c) General hyperactivity
d) Loss of righting reflex correct answers d) Loss of righting reflex
Which drug has the highest addiction liability?
a) Alcohol
b) Cocaine
c) Heroin
d) Nicotine
e) Methamphetamine correct answers c) Heroin
When initiating drug use, people first take the drug for pleasure and gratification and then shift to
_____________ reinforcement, where using the drug is used to alleviate __________________.
a) Positive; stress and anxiety
,b) Negative; stress and anxiety
c) Positive; craving
d) Negative; craving correct answers b) Negative; stress and anxiety
Why do polymorphisms in alcohol metabolism genes (for example ADH2 or ALDH1) provide
protection against alcohol use disorder? Excess what in the bloodstream causes the unpleasant
effects of drinking?
a) Acetate
b) Acetaldehyde
c) Alcohol dehydrogenase
d) Alcohol correct answers b) Acetaldehyde
Rank routes of administration from the fastest method to the slowest method to get high
concentrations of drug in the blood stream.
a) Oral, Intravenous, Smoked, Intranasal
b) Smoked, Oral, Intranasal, Intravenous
c) Intravenous, Intranasal, Oral
d) Smoked, Oral, Intranasal correct answers c) Intravenous, Intranasal, Oral
Alcohol displaces __________ to bind to LUSH, which is a protein found in _________.
a) water, Drosophila
b) GABA, bacteria
c) water, bacteria
d) zinc, humans correct answers a) water, Drosophila
Membranes are ___________________ and therefore it is harder for ____________ drugs to
cross.
a) Hydrophobic; ionized
,b) Hydrophobic; uncharged
c) Hydrophilic; ionized
d) Hydrophilic; uncharged correct answers a) Hydrophobic; ionized
Why are slo-1 knockout mice not particularly useful for studying alcohol addiction?
a) They die prenatally
b) They are viable but have too many health problems to undergo drinking experiments
c) They drink much more than wild-type mice
d) They are much more sensitive to alcohol than wild-type mice correct answers b) They are
viable but have too many health problems to undergo drinking experiments
Overall, ethanol decreases excitability in the brain. What are its effects on receptors in the brain?
a) Inhibits inhibitory receptors and inhibits excitatory receptors
b) Enhances inhibitory receptors and enhances excitatory receptors
c) Enhances inhibitory receptors and inhibits excitatory receptors
d) Inhibits inhibitory receptors and enhances excitatory receptors. correct answers c) Enhances
inhibitory receptors and inhibits excitatory receptors
The structure for Acetylsalicylic acid is shown. Based on the structure where will the majority of
drug absorption occur?
a) Stomach
b) Small Intestine
c) Liver
d) Kidney
Large Intestine correct answers a) Stomach
Acetylsalicylic acid will be absorbed in the organ in Question #11 because the drug can be
___________________ and remain ___________________.
, a) Protonated; Charged
b) Deprotonated; Charged
c) Protonated; Uncharged
d) Deprotonated; Uncharged correct answers c) Protonated; Uncharged
Naltrexone is one of three FDA-approved drugs for alcohol use disorder. What is the mechanism
of action of naltrexone?
a) GABA receptor agonist
b) Dopamine receptor antagonist
c) Opioid receptor antagonist
d) NMDA receptor antagonist correct answers c) Opioid receptor antagonist
What is the most important variable affecting absorption of drugs?
a) pH of the drug
b) Ionization of the drug
c) Rate of stomach emptying
d) Surface Area
e) Both C & D. correct answers c) Rate of stomach emptying
How does ethanol affect the probability of BK channel opening?
a) Ethanol irreversibly increases the probability of BK channel opening
b) Ethanol reversibly increases the probability of BK channel opening
c) Ethanol irreversibly decreases the probability of BK channel opening
d) Ethanol reversibly decreases the probability of BK channel opening correct answers b)
Ethanol reversibly increases the probability of BK channel opening
What was used to determine that ethanol modulation of the GABRA2 subunit is important for
specific behaviors including ethanol conditioned taste aversion and motor stimulation?
