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PHCL 3100 EXAM 2 QUESTIONS AND CORRECT ANSWERS

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PHCL 3100 EXAM 2 QUESTIONS AND CORRECT ANSWERS

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propranolol


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prototype beta adrenoceptor antagonist
unselective binding to beta receptors




pseudoephedrine


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exerts primarily indirect actions, causes effects like NE, used for
vasoconstriction (like as nasal decongestant) and to treat "stress"
incontinence in women by contracting bladder muscle

,Naloxone


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•Mechanism: Mu-opioid receptor antagonist,
blocks and reverses binding of opioids to their
receptors.
•Clinical Use: Reverses effect of opioid.
•Side Effect: Induces severe opioid withdrawal
symptoms (convulsions, sweating, anxiety) in
patients addicted to opioids.




selective arteriolar vasodilator example


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hydralazine




tubocurarine


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muscle neuromuscular junction blocking agents, act by competitive
antagonism of ACh action at NM (tubo) receptors resulting in paraylsis of
skeletal muscle; ACh fails to cause skeletal muscle contraction




which drugs do you use for acute myocardial infarctions?

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fibrinolytic agents and aspirin




fibrinolysis


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dissolution of clots




Nicotine


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agonist at both ganglionic and skeletal muscle nicotinic cholinergic
receptors




enzymes important in transmitter metabolism


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acetylcholinesterase, monoamine oxidase (MAO)




actions of M2 muscarinic agonists, resulting in decreased excitability of cardiac
excitable cells

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inhibition of adenylyl cyclase and opening of K+ channels




what does phospholipase C do?


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increases Ca2+ in cell, leads to vasoconstriction




dopamine


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causes natriuresis, dopamine infusion can stimulate the heart and increase
renal blood flow in low doses




epinephrine, norepinephrine and dopamine


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endogenous catecholamines




influence of prostaglandin E on renal function


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