What is the mechanism of Ribociclib?
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CDK4 and CDK6 interact with cyclin D1 to phosphorylate retinoblastoma
protein. Phosphorylation of Rb lads to cell cycle progression. In breast
cancer, Cyclin D1 and CdK4/6 are upregulated, increasing tumor growth.
Describe implanted female contraception.
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, Long term protection against pregnancy (months to years).
- RU486 (mifepristone), synthetic steroid blocking progesterone receptor,
degenerated uterine wall.
- Mostly for contraceptivs and early termination of pregnancy.
What is the mechanism of sulphonylureas/meglitimides?
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Block K+ chanel on Beta cells, causing insulin release.
What are some treatments of obesity?
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Anti-obesity drugs and appetite suppressants.
Describe Aspirin or Ibuprofen in pain management.
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, NSAID analgesic; non-steroidal anti-inflammatory drugs are COX-1 & -2
inhibitors, which mildly prevent synthesis of prostaglandins that stimulat
PNS and CNS nociceptors.
- mild analgesia, particularly for pain due to inflammation.
- Side effects: COX-1 inhibition causes bleeding and ulcers by inhibiting
platelet clotting and stomach mucosa.
- Other uses: NSAIDs' anticlotting effect can be used at a daily losw does
to prevent coronary artery blood clots that cause heart attacks.
Describe non-allergic asthma.
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Intrinsic, no elevation of IgE
What is Lymphoma?
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Cancer arising from lymphois tissue (lymph nodes, spleen, etc.).
What mediates allergic asthma?
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IgE
, What is Disulfiram?
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A drug to prevent alcohol misuse; it blocks further metabolism of alcohol at
the "acetaldehyde step". Ingesting alcohol results in high, nausea producing
blood levels of acetaldehyde.
- used as prophylatic
- May cause neuritis
What happens when a tumor suppressor gene becomes mutated?
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Mutations (loss of function) in these genes induces transformation.
Describe the T cell response to cancers.
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T lymphocytes are the major mediators of immune response against cancer
cells.
- Dendritic cells or antigen-presenting cells capture mutant/foreign
proteins.
- APCs prensent foreign antigens to naive T cells in lymph nodes.
- Mature cytotoxic T cells recognoze antigens on cancer cells and exert
cytotoxic effects.
Give this one a try later!
CDK4 and CDK6 interact with cyclin D1 to phosphorylate retinoblastoma
protein. Phosphorylation of Rb lads to cell cycle progression. In breast
cancer, Cyclin D1 and CdK4/6 are upregulated, increasing tumor growth.
Describe implanted female contraception.
Give this one a try later!
, Long term protection against pregnancy (months to years).
- RU486 (mifepristone), synthetic steroid blocking progesterone receptor,
degenerated uterine wall.
- Mostly for contraceptivs and early termination of pregnancy.
What is the mechanism of sulphonylureas/meglitimides?
Give this one a try later!
Block K+ chanel on Beta cells, causing insulin release.
What are some treatments of obesity?
Give this one a try later!
Anti-obesity drugs and appetite suppressants.
Describe Aspirin or Ibuprofen in pain management.
Give this one a try later!
, NSAID analgesic; non-steroidal anti-inflammatory drugs are COX-1 & -2
inhibitors, which mildly prevent synthesis of prostaglandins that stimulat
PNS and CNS nociceptors.
- mild analgesia, particularly for pain due to inflammation.
- Side effects: COX-1 inhibition causes bleeding and ulcers by inhibiting
platelet clotting and stomach mucosa.
- Other uses: NSAIDs' anticlotting effect can be used at a daily losw does
to prevent coronary artery blood clots that cause heart attacks.
Describe non-allergic asthma.
Give this one a try later!
Intrinsic, no elevation of IgE
What is Lymphoma?
Give this one a try later!
Cancer arising from lymphois tissue (lymph nodes, spleen, etc.).
What mediates allergic asthma?
Give this one a try later!
IgE
, What is Disulfiram?
Give this one a try later!
A drug to prevent alcohol misuse; it blocks further metabolism of alcohol at
the "acetaldehyde step". Ingesting alcohol results in high, nausea producing
blood levels of acetaldehyde.
- used as prophylatic
- May cause neuritis
What happens when a tumor suppressor gene becomes mutated?
Give this one a try later!
Mutations (loss of function) in these genes induces transformation.
Describe the T cell response to cancers.
Give this one a try later!
T lymphocytes are the major mediators of immune response against cancer
cells.
- Dendritic cells or antigen-presenting cells capture mutant/foreign
proteins.
- APCs prensent foreign antigens to naive T cells in lymph nodes.
- Mature cytotoxic T cells recognoze antigens on cancer cells and exert
cytotoxic effects.
