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,List all the factors that affect drug absorption - correct ans:Surface area of the body
Rate of dissolution
Lipid solubility
Blood flow
Ion pH
List the following for Aminoglycosides
Examples of drug
MOA
Adverse Effects
BBW - correct ans:Gentamycin, Neomycin, Tobramycin
MOA: Inhibits protein synthesis specific for 30 S Ribosome.
Adverse effects: nephrotoxicity, ototoxicity, draw baseline renal function Measure peak and troughs
BBW: Caution with renal disease
List the following for Tetracycine
Examples of drug
MOA
Adverse Effects
BBW
Contraindications/interactions - correct ans:Doxycycline(longer 1/2 life and less GI effects) and
tetracycline
MOA: inhibit protein synthesis at 30 S
Adverse effects: discolors teeth in children, PHOTOSENSITIVITY
, BBW: Do not use in pregnancy or breastfeeding or children under 8.
Contraindications/Interactions: do not take with iron, calcium, and magnesium. Antacids decrease
absorption. Theophylline and warfarin may increase or decrease drug absorption.
List the following for Fluroquinolones
Examples of drug
MOA
Adverse Effects
BBW - correct ans:Levofloxacin, Ciprofloxacin
MOA: Inhibits DNA and RNA replication - bacterioidal
Adverse effects: PHOTOTOXICITY
BBW: Tendon rupture and myasthenia gravis
List the following for Metronidazole
Examples of drug
MOA
Adverse Effects
BBW - correct ans:Flagyl
MOA: antiparasitic
Adverse effects: headache, nausea
BBW: DO NOT take with ETOH (72 hours) and avoi in first trimester