Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical abilities.5.2. The Role of Law ExamsLaw exams, in comparison, focus more on assessing a
student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
Denise G. Anderson
UNIVER SI TY OF WASHINGTON
Sarah N. Salm
BOROUGH OF MANHATTAN
COMMUNITY COLLEGE
Mira Beins
UNIVER SI TY OF WASHINGTON
Eugene W. Nester
UNIVER SI TY OF WASHINGTON
Tenth Edition
and35508_fm_i-xxxii.indd 1 10/14/20 3:56 AM
,Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical abilities.5.2. The Role of Law ExamsLaw exams, in comparison, focus more on assessing a
student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing Skills: Business
exams may require students to present ideas clearly and concisely
NESTER’S MICROBIOLOGY: A HUMAN PERSPECTIVE, TENTH EDITION
Published by McGraw Hill LLC, 1325 Avenue of the Americas, New York, NY 10121. Copyright © 2022
by McGraw Hill LLC. All rights reserved. Printed in the United States of America. Previous editions
© 2019, 2016, and 2012. No part of this publication may be reproduced or distributed in any form or by any
means, or stored in a database or retrieval system, without the prior written consent of McGraw Hill LLC,
including, but not limited to, in any network or other electronic storage or transmission, or broadcast for
distance learning.
Some ancillaries, including electronic and print components, may not be available to customers outside the
United States.
This book is printed on acid-free paper.
1 2 3 4 5 6 7 8 9 LWI 23 22 21
ISBN 978-1-260-73550-5 (bound edition)
MHID 1-260-73550-8 (bound edition)
ISBN 978-1-264-34198-6 (loose-leaf edition)
MHID 1-264-34198-9 (loose-leaf edition)
Portfolio Manager: Lauren Vondra
Product Developer: Erin DeHeck
Marketing Manager: Tami Hodge
Content Project Managers: Laura Bies / Rachael Hillebrand
Senior Buyer: Laura Fuller
Lead Designer: David Hash
Content Licensing Specialist: Beth Cray
Cover Image: ©National Institute of Allergy and Infectious Diseases (NIAID)
Compositor: MPS Limited
All credits appearing on page or at the end of the book are considered to be an extension of the copyright
page.
Library of Congress Cataloging-in-Publication Data
Names: Anderson, Denise G. (Denise Gayle), author. | Salm, Sarah, author. |
Beins, Mira, author. | Allen, Deborah (Deborah Patricia), author.
Title: Nester’s microbiology : a human perspective / Denise G. Anderson,
Sarah N. Salm, Mira Beins, [Deborah Allen].
Other titles: Microbiology
Description: Tenth edition. | New York, NY : McGraw Hill Education, [2022]
| Includes index.
Identifiers: LCCN 2020041282 | ISBN 9781260735505 (hardcover; alk. paper)
Subjects: MESH: Microbiological Phenomena | Microbiological Techniques |
Communicable Diseases–microbiology
Classification: LCC QR41.2 | NLM QW 4 | DDC 579–dc23
LC record available at https://lccn.loc.gov/2020041282
The Internet addresses listed in the text were accurate at the time of publication. The inclusion of a website
does not indicate an endorsement by the authors or McGraw Hill LLC, and McGraw Hill LLC does not
guarantee the accuracy of the information presented at these sites.
mheducation.com/highered
and35508_fm_i-xxxii.indd 2 10/14/20 3:56 AM
, Brief Contents
PART I PART IV
Life and Death of Microorganisms Infectious Diseases
1. Humans and the Microbial World 1 21. Respiratory System Infections 536
2. The Molecules of Life 20 22. Skin Infections 582
3. Cells and Methods to Observe Them 44 23. Wound Infections 609
4. Dynamics of Microbial Growth 90 24. Digestive System Infections 630
5. Control of Microbial Growth 117 25. Blood and Lymphatic Infections 672
6. Microbial Metabolism: Fueling Cell Growth 137 26. Nervous System Infections 703
7. The Blueprint of Life, from DNA to Protein 175 27. Genitourinary Tract Infections 738
8. Bacterial Genetics 203
9. Biotechnology 232
PART V
Applied Microbiology
PART I I 28. Microbial Ecology 777
The Microbial World 29. Environmental Microbiology: Treatment of Water,
10. Identifying and Classifying Microorganisms 255 Wastes, and Polluted Habitats 796
11. The Diversity of Bacteria and Archaea 274 30. Food Microbiology 810
12. The Eukaryotic Members of the Microbial
APPENDICES A–1
World 305
GLOSSARY/INDEX GI–1
13. Viruses, Viroids, and Prions 329
entrepreneurship, and international business.1.2. Structure of Business ExamsBusiness exams are often a mix of theoretical knowledge and practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing
Skills: Business exams may require students to Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical abilities.5.2. The Role of Law ExamsLaw
exams, in comparison, focus more on assessing a student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
PART I I I
Microorganisms and Humans
14. The Innate Immune Response 360
15. The Adaptive Immune Response 385
16. Host-Microbe Interactions 415
17. Applications of Immune Responses 439
18. Immunological Disorders 464
19. Epidemiology 481
20. Antimicrobial Medications 504
iii
and35508_fm_i-xxxii.indd 3 10/14/20 3:56 AM
, About the Authors
The Nester Team: Mira Beins
Mira Beins is an Associate Teaching Pro-
Different Perspectives, One Vision, One Voice fessor in the Department of Microbiology
The authors of this edition may be a set of individuals with different at the University of Washington, where she
insights and unique experiences, but their cooperative relationship teaches general microbiology, medical bacte-
defines the word “team.” What drives them is a single shared goal: riology, and medical mycology/parasitology.
to create the most learning-friendly introductory microbiology text- She completed her undergraduate studies in
book available. Each chapter was edited with students in mind, using Mira Beins Molecular Biology and Biotechnology at the
simpler words where appropriate while maintaining the scientific University of the Philippines before mov-
rigor so important for today’s healthcare professionals. ing to Wisconsin for graduate work in Microbiology. Her graduate
and postdoctoral research both focused on virology, which solidified
her belief that viruses are amazing—although she now begrudgingly
Denise Anderson admits that bacteria, fungi, and eukaryotic parasites are pretty cool, too.
Denise Anderson is a Senior Lecturer Mira lives in Seattle with her husband Mike and two kids, Maya
Emeritus in the Department of Microbiol- and Noah. When she’s not busy teaching or driving the kids to their
ogy at the University of Washington, where many activities, she enjoys reading books, watching movies, hang-
she taught a variety of courses including ing out with friends and family, and planning the next family trip
general microbiology, medical bacteriol- (which Denise hopes will be to the Yorkshire Dales!).
ogy laboratory, recombinant DNA tech-
niques, and medical mycology/parasitology Deborah Allen
Richard Moore laboratory for over 30 years. Equipped with
a diverse educational background, includ- Deborah Allen is a Professor at Jefferson
College in Missouri, where she teaches
ing undergraduate work in nutrition and graduate work in food sci-
microbiology as well as several other
ence and in microbiology, she first discovered a passion for teaching
courses for students entering allied health
when she taught microbiology laboratory courses as part of her
careers. Her graduate work was in zoology
graduate training. Her enthusiastic teaching style, fueled by regu-
at the University of Oklahoma and in neuro-
lar doses of Seattle’s famous coffee, received high reviews from her
biology and behavior at Cornell University.
students. Mike Bohrer
She participated in cancer research at the
Denise now relaxes in the Yorkshire Dales of England, where
University of Arkansas Medical Center before embarking on a career
she lives with her husband, Richard Moore. When not editing text-
in publishing, working in acquisitions and development for books in
book chapters, she can usually be found walking scenic footpaths,
the life sciences. She is now thrilled to be working on the other end of
chatting with friends, fighting weeds in her garden, or enjoying a
the desk with the Nester team. Away from campus, Deborah reads or
fermented beverage at the local pub.
listens to her favorite Eve Dallas novels, floats the rivers and listens
to folk music in the Ozarks, and fully appreciates the local microbes
while visiting Missouri wineries.
Sarah Salm
Sarah Salm is a Professor at the Borough of
Manhattan Community College (BMCC) Eugene Nester
of the City University of New York, Gene (Eugene) Nester was instrumental in
where she teaches microbiology, anatomy establishing the text’s reputation for excel-
and physiology, and general biology. She lence over the decades. Although no lon-
earned her undergraduate and doctoral ger an active member of the author team,
degrees at the University of the Witwa- he wrote the original version of the present
Sandy Coetzee
tersrand in Johannesburg, South Africa. text with Evans Roberts and Nancy Pearsall
She later moved to New York, where she did postdoctoral work at more than 30 years ago. That text, Microbi-
Courtesy Eugene Nester
the NYU School of Medicine. Her research background is diverse ology: Molecules, Microbes and Man, pio-
and includes plant virology, prostate cancer, and bacteria in con- neered the organ system approach to the study of infectious disease
taminated water sources. and was developed specifically for allied health sciences.
entrepreneurship, and international business.1.2. Structure of Business ExamsBusiness exams are often a mix of theoretical knowledge and practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing
Skills: Business exams may require students to present ideas clearly and concisely Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical
abilities.5.2. The Role of Law ExamsLaw exams, in comparison, focus more on assessing a student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
iv
and35508_fm_i-xxxii.indd 4 10/14/20 3:56 AM
student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
Denise G. Anderson
UNIVER SI TY OF WASHINGTON
Sarah N. Salm
BOROUGH OF MANHATTAN
COMMUNITY COLLEGE
Mira Beins
UNIVER SI TY OF WASHINGTON
Eugene W. Nester
UNIVER SI TY OF WASHINGTON
Tenth Edition
and35508_fm_i-xxxii.indd 1 10/14/20 3:56 AM
,Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical abilities.5.2. The Role of Law ExamsLaw exams, in comparison, focus more on assessing a
student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing Skills: Business
exams may require students to present ideas clearly and concisely
NESTER’S MICROBIOLOGY: A HUMAN PERSPECTIVE, TENTH EDITION
Published by McGraw Hill LLC, 1325 Avenue of the Americas, New York, NY 10121. Copyright © 2022
by McGraw Hill LLC. All rights reserved. Printed in the United States of America. Previous editions
© 2019, 2016, and 2012. No part of this publication may be reproduced or distributed in any form or by any
means, or stored in a database or retrieval system, without the prior written consent of McGraw Hill LLC,
including, but not limited to, in any network or other electronic storage or transmission, or broadcast for
distance learning.
Some ancillaries, including electronic and print components, may not be available to customers outside the
United States.
This book is printed on acid-free paper.
1 2 3 4 5 6 7 8 9 LWI 23 22 21
ISBN 978-1-260-73550-5 (bound edition)
MHID 1-260-73550-8 (bound edition)
ISBN 978-1-264-34198-6 (loose-leaf edition)
MHID 1-264-34198-9 (loose-leaf edition)
Portfolio Manager: Lauren Vondra
Product Developer: Erin DeHeck
Marketing Manager: Tami Hodge
Content Project Managers: Laura Bies / Rachael Hillebrand
Senior Buyer: Laura Fuller
Lead Designer: David Hash
Content Licensing Specialist: Beth Cray
Cover Image: ©National Institute of Allergy and Infectious Diseases (NIAID)
Compositor: MPS Limited
All credits appearing on page or at the end of the book are considered to be an extension of the copyright
page.
Library of Congress Cataloging-in-Publication Data
Names: Anderson, Denise G. (Denise Gayle), author. | Salm, Sarah, author. |
Beins, Mira, author. | Allen, Deborah (Deborah Patricia), author.
Title: Nester’s microbiology : a human perspective / Denise G. Anderson,
Sarah N. Salm, Mira Beins, [Deborah Allen].
Other titles: Microbiology
Description: Tenth edition. | New York, NY : McGraw Hill Education, [2022]
| Includes index.
Identifiers: LCCN 2020041282 | ISBN 9781260735505 (hardcover; alk. paper)
Subjects: MESH: Microbiological Phenomena | Microbiological Techniques |
Communicable Diseases–microbiology
Classification: LCC QR41.2 | NLM QW 4 | DDC 579–dc23
LC record available at https://lccn.loc.gov/2020041282
The Internet addresses listed in the text were accurate at the time of publication. The inclusion of a website
does not indicate an endorsement by the authors or McGraw Hill LLC, and McGraw Hill LLC does not
guarantee the accuracy of the information presented at these sites.
mheducation.com/highered
and35508_fm_i-xxxii.indd 2 10/14/20 3:56 AM
, Brief Contents
PART I PART IV
Life and Death of Microorganisms Infectious Diseases
1. Humans and the Microbial World 1 21. Respiratory System Infections 536
2. The Molecules of Life 20 22. Skin Infections 582
3. Cells and Methods to Observe Them 44 23. Wound Infections 609
4. Dynamics of Microbial Growth 90 24. Digestive System Infections 630
5. Control of Microbial Growth 117 25. Blood and Lymphatic Infections 672
6. Microbial Metabolism: Fueling Cell Growth 137 26. Nervous System Infections 703
7. The Blueprint of Life, from DNA to Protein 175 27. Genitourinary Tract Infections 738
8. Bacterial Genetics 203
9. Biotechnology 232
PART V
Applied Microbiology
PART I I 28. Microbial Ecology 777
The Microbial World 29. Environmental Microbiology: Treatment of Water,
10. Identifying and Classifying Microorganisms 255 Wastes, and Polluted Habitats 796
11. The Diversity of Bacteria and Archaea 274 30. Food Microbiology 810
12. The Eukaryotic Members of the Microbial
APPENDICES A–1
World 305
GLOSSARY/INDEX GI–1
13. Viruses, Viroids, and Prions 329
entrepreneurship, and international business.1.2. Structure of Business ExamsBusiness exams are often a mix of theoretical knowledge and practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing
Skills: Business exams may require students to Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical abilities.5.2. The Role of Law ExamsLaw
exams, in comparison, focus more on assessing a student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
PART I I I
Microorganisms and Humans
14. The Innate Immune Response 360
15. The Adaptive Immune Response 385
16. Host-Microbe Interactions 415
17. Applications of Immune Responses 439
18. Immunological Disorders 464
19. Epidemiology 481
20. Antimicrobial Medications 504
iii
and35508_fm_i-xxxii.indd 3 10/14/20 3:56 AM
, About the Authors
The Nester Team: Mira Beins
Mira Beins is an Associate Teaching Pro-
Different Perspectives, One Vision, One Voice fessor in the Department of Microbiology
The authors of this edition may be a set of individuals with different at the University of Washington, where she
insights and unique experiences, but their cooperative relationship teaches general microbiology, medical bacte-
defines the word “team.” What drives them is a single shared goal: riology, and medical mycology/parasitology.
to create the most learning-friendly introductory microbiology text- She completed her undergraduate studies in
book available. Each chapter was edited with students in mind, using Mira Beins Molecular Biology and Biotechnology at the
simpler words where appropriate while maintaining the scientific University of the Philippines before mov-
rigor so important for today’s healthcare professionals. ing to Wisconsin for graduate work in Microbiology. Her graduate
and postdoctoral research both focused on virology, which solidified
her belief that viruses are amazing—although she now begrudgingly
Denise Anderson admits that bacteria, fungi, and eukaryotic parasites are pretty cool, too.
Denise Anderson is a Senior Lecturer Mira lives in Seattle with her husband Mike and two kids, Maya
Emeritus in the Department of Microbiol- and Noah. When she’s not busy teaching or driving the kids to their
ogy at the University of Washington, where many activities, she enjoys reading books, watching movies, hang-
she taught a variety of courses including ing out with friends and family, and planning the next family trip
general microbiology, medical bacteriol- (which Denise hopes will be to the Yorkshire Dales!).
ogy laboratory, recombinant DNA tech-
niques, and medical mycology/parasitology Deborah Allen
Richard Moore laboratory for over 30 years. Equipped with
a diverse educational background, includ- Deborah Allen is a Professor at Jefferson
College in Missouri, where she teaches
ing undergraduate work in nutrition and graduate work in food sci-
microbiology as well as several other
ence and in microbiology, she first discovered a passion for teaching
courses for students entering allied health
when she taught microbiology laboratory courses as part of her
careers. Her graduate work was in zoology
graduate training. Her enthusiastic teaching style, fueled by regu-
at the University of Oklahoma and in neuro-
lar doses of Seattle’s famous coffee, received high reviews from her
biology and behavior at Cornell University.
students. Mike Bohrer
She participated in cancer research at the
Denise now relaxes in the Yorkshire Dales of England, where
University of Arkansas Medical Center before embarking on a career
she lives with her husband, Richard Moore. When not editing text-
in publishing, working in acquisitions and development for books in
book chapters, she can usually be found walking scenic footpaths,
the life sciences. She is now thrilled to be working on the other end of
chatting with friends, fighting weeds in her garden, or enjoying a
the desk with the Nester team. Away from campus, Deborah reads or
fermented beverage at the local pub.
listens to her favorite Eve Dallas novels, floats the rivers and listens
to folk music in the Ozarks, and fully appreciates the local microbes
while visiting Missouri wineries.
Sarah Salm
Sarah Salm is a Professor at the Borough of
Manhattan Community College (BMCC) Eugene Nester
of the City University of New York, Gene (Eugene) Nester was instrumental in
where she teaches microbiology, anatomy establishing the text’s reputation for excel-
and physiology, and general biology. She lence over the decades. Although no lon-
earned her undergraduate and doctoral ger an active member of the author team,
degrees at the University of the Witwa- he wrote the original version of the present
Sandy Coetzee
tersrand in Johannesburg, South Africa. text with Evans Roberts and Nancy Pearsall
She later moved to New York, where she did postdoctoral work at more than 30 years ago. That text, Microbi-
Courtesy Eugene Nester
the NYU School of Medicine. Her research background is diverse ology: Molecules, Microbes and Man, pio-
and includes plant virology, prostate cancer, and bacteria in con- neered the organ system approach to the study of infectious disease
taminated water sources. and was developed specifically for allied health sciences.
entrepreneurship, and international business.1.2. Structure of Business ExamsBusiness exams are often a mix of theoretical knowledge and practical application. Depending on the subject area, these exams can vary significantly in format. Common types of business exams and Writing
Skills: Business exams may require students to present ideas clearly and concisely Price, Place, and Promotion) are crucial business skills that students must be proficient in. Exams help solidify these skills, ensuring that students leave school with both theoretical knowledge and practical
abilities.5.2. The Role of Law ExamsLaw exams, in comparison, focus more on assessing a student’s capacity for logical reasoning and the application of legal doctrines to particular cases. Law education is structured
iv
and35508_fm_i-xxxii.indd 4 10/14/20 3:56 AM
