NR565 Week 4 Midterm Exam –
Advanced Pharmacology Fundamentals
Edition – Question Actual Exam
Original Practice Midterm Exam (2026–2027 Edition)
Question 1
A nurse practitioner prescribes lisinopril for a patient with newly diagnosed hypertension.
Which laboratory value should be monitored most closely after therapy is initiated?
A. Hemoglobin
B. Serum potassium
C. Platelet count
D. White blood cell count
Correct Answer
✅ B. Serum potassium
Solution
ACE inhibitors decrease aldosterone secretion, increasing the risk of hyperkalemia, especially
in patients with kidney disease or those taking potassium supplements or potassium-sparing
diuretics.
Rationales
✅
● A. Incorrect. Hemoglobin is not routinely affected.
● B. Correct.
, ● C. Incorrect. Platelets are not routinely monitored.
● D. Incorrect. WBC monitoring is unnecessary.
Question 2
Which phase of pharmacokinetics describes the movement of a drug from the bloodstream into
body tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer
✅ B. Distribution
Solution
Distribution is the process by which a drug moves from the systemic circulation to tissues and
organs.
Rationales
✅
● A. Incorrect. Absorption is entry into the bloodstream.
● B. Correct.
● C. Incorrect. Metabolism is chemical alteration, primarily in the liver.
● D. Incorrect. Excretion is drug elimination.
Question 3
A patient taking warfarin begins therapy with trimethoprim-sulfamethoxazole. Which
complication is most likely?
A. Decreased INR
B. Increased risk of bleeding
,C. Severe hypertension
D. Hyperglycemia
Correct Answer
✅ B. Increased risk of bleeding
Solution
Trimethoprim-sulfamethoxazole can inhibit warfarin metabolism, increasing the INR and
bleeding risk.
Rationales
✅
● A. Incorrect. INR typically increases.
● B. Correct.
● C. Incorrect.
● D. Incorrect.
Question 4
Which receptor is primarily stimulated by albuterol?
A. Alpha-1
B. Beta-1
C. Beta-2
D. Muscarinic
Correct Answer
✅ C. Beta-2
Solution
Albuterol selectively stimulates beta-2 receptors, causing bronchodilation.
Rationales
● A. Incorrect. Alpha-1 causes vasoconstriction.
, ✅
● B. Incorrect. Beta-1 primarily affects the heart.
● C. Correct.
● D. Incorrect. Muscarinic receptors are part of the parasympathetic system.
Question 5
Which statement best describes a drug half-life?
A. Time required for a drug to reach peak concentration
B. Time required for 50% of the drug to be eliminated
C. Time required for absorption
D. Time required for complete metabolism
Correct Answer
✅ B. Time required for 50% of the drug to be eliminated
Solution
Half-life helps determine dosing intervals and the time required to reach steady state.
Rationales
✅
● A. Incorrect.
● B. Correct.
● C. Incorrect.
● D. Incorrect.
Question 6
Which medication should not be used during pregnancy because of fetal toxicity?
A. Methyldopa
B. Lisinopril
C. Labetalol
Advanced Pharmacology Fundamentals
Edition – Question Actual Exam
Original Practice Midterm Exam (2026–2027 Edition)
Question 1
A nurse practitioner prescribes lisinopril for a patient with newly diagnosed hypertension.
Which laboratory value should be monitored most closely after therapy is initiated?
A. Hemoglobin
B. Serum potassium
C. Platelet count
D. White blood cell count
Correct Answer
✅ B. Serum potassium
Solution
ACE inhibitors decrease aldosterone secretion, increasing the risk of hyperkalemia, especially
in patients with kidney disease or those taking potassium supplements or potassium-sparing
diuretics.
Rationales
✅
● A. Incorrect. Hemoglobin is not routinely affected.
● B. Correct.
, ● C. Incorrect. Platelets are not routinely monitored.
● D. Incorrect. WBC monitoring is unnecessary.
Question 2
Which phase of pharmacokinetics describes the movement of a drug from the bloodstream into
body tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer
✅ B. Distribution
Solution
Distribution is the process by which a drug moves from the systemic circulation to tissues and
organs.
Rationales
✅
● A. Incorrect. Absorption is entry into the bloodstream.
● B. Correct.
● C. Incorrect. Metabolism is chemical alteration, primarily in the liver.
● D. Incorrect. Excretion is drug elimination.
Question 3
A patient taking warfarin begins therapy with trimethoprim-sulfamethoxazole. Which
complication is most likely?
A. Decreased INR
B. Increased risk of bleeding
,C. Severe hypertension
D. Hyperglycemia
Correct Answer
✅ B. Increased risk of bleeding
Solution
Trimethoprim-sulfamethoxazole can inhibit warfarin metabolism, increasing the INR and
bleeding risk.
Rationales
✅
● A. Incorrect. INR typically increases.
● B. Correct.
● C. Incorrect.
● D. Incorrect.
Question 4
Which receptor is primarily stimulated by albuterol?
A. Alpha-1
B. Beta-1
C. Beta-2
D. Muscarinic
Correct Answer
✅ C. Beta-2
Solution
Albuterol selectively stimulates beta-2 receptors, causing bronchodilation.
Rationales
● A. Incorrect. Alpha-1 causes vasoconstriction.
, ✅
● B. Incorrect. Beta-1 primarily affects the heart.
● C. Correct.
● D. Incorrect. Muscarinic receptors are part of the parasympathetic system.
Question 5
Which statement best describes a drug half-life?
A. Time required for a drug to reach peak concentration
B. Time required for 50% of the drug to be eliminated
C. Time required for absorption
D. Time required for complete metabolism
Correct Answer
✅ B. Time required for 50% of the drug to be eliminated
Solution
Half-life helps determine dosing intervals and the time required to reach steady state.
Rationales
✅
● A. Incorrect.
● B. Correct.
● C. Incorrect.
● D. Incorrect.
Question 6
Which medication should not be used during pregnancy because of fetal toxicity?
A. Methyldopa
B. Lisinopril
C. Labetalol
